JaxCC1: Multisystem phenotyping of 18 Collaborative Cross strains (2018)

The Jackson Laboratory

         
Ontology terms mapped to JaxCC1 measures:
    MA:0000009   adipose tissue
    MA:0000059   blood
    MA:0000072   heart
    MA:0000615   forelimb muscle
    MA:0000692   limb muscle
    MA:0001459   bone
    MA:0002443   auditory system
    MA:0002501   plasma
    MA:0002545   urine
    MP:0000180   abnormal circulating cholesterol level
    MP:0000184   abnormal circulating HDL cholesterol level
    MP:0000188   abnormal circulating glucose level
    MP:0000199   abnormal circulating serum albumin level
    MP:0000202   abnormal circulating alkaline phosphatase level
    MP:0000203   abnormal circulating aspartate transaminase level
    MP:0000217   abnormal leukocyte cell number
    MP:0000226   abnormal mean corpuscular volume
    MP:0000717   abnormal lymphocyte cell number
    MP:0001256   abnormal body length
    MP:0001259   abnormal body weight
    MP:0001362   abnormal anxiety-related response
    MP:0001392   abnormal locomotor behavior
    MP:0001515   abnormal grip strength
    MP:0001516   abnormal motor coordination/balance
    MP:0001553   abnormal circulating free fatty acids level
    MP:0001560   abnormal circulating insulin level
    MP:0001562   abnormal circulating calcium level
    MP:0001565   abnormal circulating phosphate level
    MP:0001569   abnormal circulating bilirubin level
    MP:0001573   abnormal circulating alanine transaminase level
    MP:0001586   abnormal erythrocyte cell number
    MP:0001588   abnormal hemoglobin
    MP:0001589   abnormal mean corpuscular hemoglobin
    MP:0001629   abnormal heart rate
    MP:0001758   abnormal urine glucose level
    MP:0001776   abnormal circulating sodium level
    MP:0002586   abnormal platelet volume
    MP:0002596   abnormal hematocrit
    MP:0002602   abnormal eosinophil cell number
    MP:0002668   abnormal circulating potassium level
    MP:0003018   abnormal circulating chloride level
    MP:0003360   abnormal depression-related behavior
    MP:0003795   abnormal bone structure
    MP:0003860   abnormal carbon dioxide level
    MP:0003897   abnormal ST segment
    MP:0003898   abnormal QRS complex
    MP:0003899   abnormal QT interval
    MP:0003901   abnormal PR interval
    MP:0003959   abnormal lean body mass
    MP:0004152   abnormal circulating iron level
    MP:0004738   abnormal auditory brainstem response
    MP:0004857   abnormal heart weight
    MP:0005265   abnormal blood urea nitrogen level
    MP:0005451   abnormal body composition
    MP:0005452   abnormal adipose tissue amount
    MP:0005457   abnormal percent body fat/body weight
    MP:0005640   abnormal mean corpuscular hemoglobin concentration
    MP:0006315   abnormal urine protein level
    MP:0008849   abnormal hemoglobin concentration distribution width
    MP:0010066   abnormal red blood cell distribution width
    MP:0010122   abnormal bone mineral content
    MP:0010504   abnormal RR interval
    MP:0011434   abnormal urine magnesium level
    MP:0011469   abnormal urine creatinine level
    MP:0011888   abnormal circulating total protein level
    MP:0011898   abnormal platelet cell number
    MP:0011913   abnormal reticulocyte cell number
    MP:0011918   abnormal PQ interval
    MP:0011919   abnormal R wave
    MP:0011969   abnormal circulating triglyceride level
    MP:0012321   abnormal total tissue mass
    MP:0012360   abnormal large unstained cell number
    MP:0012397   abnormal nucleated erythrocyte cell number
    MP:0012440   abnormal neutrophil cell number
    MP:0012441   abnormal monocyte cell number
    MP:0012442   abnormal basophil cell number
    MP:0013189   abnormal exploration in a new environment
    MP:0020147   abnormal defecation amount
    MP:0020153   abnormal urine albumin level
    VT:0000180   blood cholesterol amount
    VT:0000184   blood HDL cholesterol amount
    VT:0000188   blood glucose amount
    VT:0000199   blood albumin amount
    VT:0000202   blood alkaline phosphatase amount
    VT:0000203   blood aspartate transaminase amount
    VT:0000217   leukocyte quantity
    VT:0000222   neutrophil quantity
    VT:0000223   monocyte quantity
    VT:0000231   heart excitatory physiology trait
    VT:0000248   erythrocyte size trait
    VT:0000366   brainstem auditory evoked potential
    VT:0000717   lymphocyte quantity
    VT:0001256   body length
    VT:0001259   body mass
    VT:0001392   locomotor behavior trait
    VT:0001516   motor coordination/balance trait
    VT:0001553   blood free fatty acid amount
    VT:0001560   blood insulin amount
    VT:0001562   blood calcium amount
    VT:0001565   blood phosphate amount
    VT:0001569   blood bilirubin amount
    VT:0001573   blood alanine transaminase amount
    VT:0001586   erythrocyte quantity
    VT:0001588   blood hemoglobin amount
    VT:0001756   urine production trait
    VT:0001757   urine molecular composition trait
    VT:0001758   urine glucose amount
    VT:0001776   blood sodium amount
    VT:0002136   kidney physiology trait
    VT:0002329   blood gas amount
    VT:0002447   erythrocyte morphology trait
    VT:0002602   eosinophil quantity
    VT:0002607   basophil quantity
    VT:0002644   blood triglyceride amount
    VT:0002668   blood potassium amount
    VT:0002847   glomerular filtration trait
    VT:0002871   urine albumin amount
    VT:0003018   blood chloride amount
    VT:0003088   prepulse inhibition trait
    VT:0003135   reticulocyte quantity
    VT:0003179   platelet quantity
    VT:0004152   blood iron amount
    VT:0004262   physical strength trait
    VT:0005007   bone mineral mass
    VT:0005265   blood urea nitrogen amount
    VT:0005452   adipose amount
    VT:0005567   blood total protein amount
    VT:0007028   heart mass
    VT:0010003   bone morphology trait
    VT:0010080   skeletal muscle physiology trait
    VT:0010457   platelet size trait
    VT:0010462   defecation behavior trait
    VT:0010471   exploratory behavior trait
    VT:0010482   body fat mass
    VT:0010483   body lean mass
    VT:0010716   anxiety-related behavior trait
    VT:0010725   startle reflex trait
    VT:0015015   depression-related behavior trait
    VT:2000009   heart pumping trait
Institutional authorship The Jackson Laboratory
Project type Phenotype strain survey data set
MPD identifiersJaxCC1     MPD:519
Data changelog No updates/corrections.       Initial release date: 04/2019.
Formatted citation
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Summary of procedures that were conducted
• open field test Locomotor, exploratory, and anxiety-related behavior. 20 min test, some at 5 min intervals.
• ABR test Auditory brainstem response.
• hole board test Exploratory behavior.
• acoustic startle test Acoustic startle response, prepulse inhibition.
• light-dark box Anxiety, avoidance behavior. 20 min test.
• ECG Heart rate and wave intervals. Conscious.
• tail suspension test Latency to immobility, duration of immobility.
• rotarod Latency to fall from accelerating rotarod. 5 trials.
• grip strength 3 trials.
• DXA Body mass, fat mass, lean mass, bone mineral density and content, bone area.
• urinalysis Microalbumin, creatinine, ratio.
• organ weights Heart weight. Raw and normalized to body weight.
• metabolic panel Clinical blood chemistry (plasma). No fast.
• lipid profile Cholesterol, HDL, triglycerides, fatty acids. No fast, plasma.
• hormone quantification Insulin (plasma).
• complete blood count Hematology.
Mice: CC   18 strains   ♀♂   age various