News



Recent updates:

21 Oct 2019:   Animal IDs were modified in 50 MPD projects, so that animal IDs are now unique within a project. Original IDs were retained and a qualifier was appended where necessary.

19 Aug 2019:   PyLMM GWAS analyses have been added.

19 Aug 2019:   GxL replicability analysis tool (phase 1) has been added.

View earlier news items
31 May 2019:   Ontology navigation has been added.

31 May 2019:   Some new API endpoints have been added.

11 Mar 2019:   Various new data sets (see list below) and functionality improvements.

30 Jan 2019:   A new visualization is available for DO phenotype measures... here's an example. A new Ratios and Differences View is now available via the phenotype tools page.

27 Nov 2018:   A new Curves Comparison View is now present on measure series views and via the phenotype tools page.

27 Nov 2018:   MPD's individual strain pages link to MGI's new strain pages.

12 Oct 2018:   Data for a number of new compounds has been added to MPD's portal (ITP1) for National Institute on Aging's Interventions Testing Program (effects of various treatments on lifespan and related phenotypes).


07 Aug 2018:   A new Multivariate Outlier Detection tool has been added. Available via the phenotype tools page. See our statistical analysis glossary for more info.

24 July 2018:   Various new data sets (see list below) and functionality improvements.

24 April 2018:   A new updated phenotype tool has been added. From the phenotype tools page click on either the "Strain means table and downloads" or "Find strains by criteria fit" buttons. The tool can be used to view strain means from an arbitrary set of measures in a sortable table, download arbitrary strain means as CSV or JSON, as well as perform criteria fit analysis to find strains that best meet one or more "high", "medium", "low" criteria.

29 December, 2017:   Web app update

This update includes enhancements to phenotype correlations and scatterplot tools, including support for individual animal data points and unadjusted strain means, as well as look and feel updates. We also upgraded our infrastructure to use Python 3.6.


18 September, 2017:   Web app update

Enhanced phenotype tools usage, including ways to deploy several tools together on one page.


7 August, 2017:   Web app update
    • new data sets added and several SNP data sets reinstated
    • new user feedback form (via web page footers)
    • a new way to list phenotype measure sets by study design type (via Menu pulldown)
    • new SNP strains selection feature (when a specific data set is selected)
    • incremental enhancements to data displays and visualizations
    • urls are now https

7 June, 2017:   A completely new version of MPD's web application released

All aspects of our resource have been revisited. All pages have updated navigation patterns and appearance. Some new data visualizations are included; development of new tools, visualizations, and new data sharing capabilities is ongoing.

Regular MPD users will note the following differences that could impact their activities: MPD's customized phenotype categorization has been discontinued in favor of standard ontologies. Individual strain pages now emphasize searching for desired data rather than category listings. Most gene expression functionality has been discontinued. The old app's "shopping cart" has been replaced by "MyMPD". MyMPD can be used in guest mode or by registering. Old shopping cart contents are not automatically brought forward into MyMPD; users with needs in this area should contact us.

Please contact us if we can help with transitionary issues. Our goal is to accommodate user needs during this transition to the extent possible.


Current publication
An article about MPD appears in the Nucleic Acids Research 2018 Database Issue



Recent data set releases / history
• Data changelog

11 / 2019:     Hadsell2
Analysis of milk minerals in 31 inbred strains of mice

11 / 2019:     Neuner1
Motor function, spatial learning and memory function, anxiety-related behaviors, and beta-amyloid levels in Alzheimer’s Disease mouse models (AD-BXD)

10 / 2019:     Zaytseva1
IgG glycome: Glycan levels in 111 Collaborative Cross strains of mice

10 / 2019:     Zaytseva2
IgG glycome: N-glycan profiles of IgG subclasses in 95 Collaborative Cross strains of mice

09 / 2019:     Recla2
Late phase formalin pain response in a Diversity Outbred (DO) mouse population

09 / 2019:     Xenakis1
Antipsychotic behavioral phenotypes in 73 F1 hybrids (RIX) of Collaborative Cross strains of mice

04 / 2019:     Brinkmeyer1
Susceptibility to Theiler's murine encephalomyelitis virus in 5 Collaborative Cross strains of mice

04 / 2019:     Geuther1
Locomotor activity in 47 inbred strains of mice and 11 F1 hybrids

04 / 2019:     JaxCC1
Multisystem phenotyping of 18 Collaborative Cross strains

04 / 2019:     Sunde1
Selenium regulation of selenoprotein enzyme activity and transcripts in 8 inbred founder strains of the Collaborative Cross

03 / 2019:     Bolivar3
Intra-strain social interactions in 7 inbred strains of mice

03 / 2019:     Bolivar4
Intrasession and intersession changes in locomotor activity in response to a novel environment over time (habituation) in 14 inbred strains of mice

03 / 2019:     Lesage1
Immunological variation in 68 Collaborative Cross strains of mice and 8 founder strains

01 / 2019:     Bolivar1
Locomotor activity and exploratory behavior in 10 strains of mice

01 / 2019:     Bolivar2
Contextual and cued fear conditioning behavior in 8 inbred strains of mice

01 / 2019:     Jaxpheno18
Multi-system assessment of B6.129P2-Apoetm1Unc/J and B6.129S7-Ldlrtm1Her/J mice

01 / 2019:     Jaxpheno19
Multi-system assessment of MRL/MpJ-Faslpr/J mice

01 / 2019:     Payseur2
Hybrid male sterility in F2 progeny from a WSB/EiJ x PWD/PhJ intercross

01 / 2019:     Powell1
Susceptibility of 8 inbred founder strains of the Collaborative Cross to colonization by Neisseria musculi

12 / 2018:     JaxKOMP-Cre
Multi-system assessment of 7 Cre driver mouse strains

12 / 2018:     Jaxpheno20
Multi-system assessment of NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice

11 / 2018:     Graham1
West Nile virus infection in males of F1 hybrids (RIX) of Collaborative Cross strains of mice

11 / 2018:     Lazear1
Male reproductive traits in 12 Collaborative Cross strains of mice

11 / 2018:     Parker1
Superovulation in 6 commonly used mouse strains

10 / 2018:     Shorter3
Litter size and composition in a diallel of Collaborative Cross founder strains

10 / 2018:     Stahl1
Blood reference levels for hematology and clinical chemistry for C57BL/6J mice

07 / 2018:     Crusio1
Spatial learning, grooming, response to novelty, inter-male aggression, and hippocampal neuroanatomy in 53 BXD recombinant inbred strains of mice

07 / 2018:     McMullan4
Body weight and composition after voluntary exercise in females of 13 Collaborative Cross strains of mice

07 / 2018:     McMullan5
Activity levels, body weight and composition after voluntary exercise in females of 2 Collaborative Cross strains of mice

07 / 2018:     McMullan6
Body weight and composition after forced exercise in 4 Collaborative Cross strains of mice

07 / 2018:     McMullan7
Energy balance traits after forced exercise in 4 Collaborative Cross strains of mice

06 / 2018:     Jaxpheno17
Multi-system assessment of BKS.cg-Dock7m-Leprdb/J mice

06 / 2018:     UCLA1
SNP data, 132,000+ locations for 248 inbred and RI strains of mice

05 / 2018:     Bubier2
Gut microbial abundance QTL in Collaborative Cross emerging lines of mice

05 / 2018:     Chesler5
Intestinal microbiota in 10 inbred strains of mice

04 / 2018:     Rusyn10
Trichloroethylene metabolism in males of two inbred strains and an F1 hybrid

04 / 2018:     Rusyn11
Tetrachloroethylene metabolism in males of two inbred strains and an F1 hybrid

04 / 2018:     Schoenrock1
Perinatal nutrition effects on anxiety- and depression-related behaviors in females of F1 hybrids (RIX) of Collaborative Cross strains of mice

02 / 2018:     Jaxpheno12
Type 1 diabetes incidence and other phenotypes in NOD/ShiLtJ mice on a 6% fat diet

02 / 2018:     Jaxpheno13
Multi-system assessment of BALB/cJ mice

02 / 2018:     Jaxpheno14
Multi-system assessment of BALB/cByJ mice

02 / 2018:     Jaxpheno15
Multi-system assessment of B6.Cg-Lepob/J mice

02 / 2018:     Jaxpheno16
Multi-system assessment of B6.BKS(D)-Leprdb/J mice

02 / 2018:     McMullan1
Body composition and forced endurance in aging females of 50 Collaborative Cross strains of mice

02 / 2018:     McMullan2
Voluntary exercise traits in aging females of 43 Collaborative Cross strains of mice

02 / 2018:     McMullan3
Body composition responses following voluntary exercise in aging females of 43 Collaborative Cross strains of mice

09 / 2017:     Palmer3
Behavioral and metabolic traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/- for the Tcf7l2 gene

09 / 2017:     Palmer4
Behavioral traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/- for the Cacna1c gene

09 / 2017:     Palmer5
Behavioral and metabolic traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/+ for the Tcf7l2 gene

09 / 2017:     Palmer6
Behavioral traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/+ for the Cacna1c gene

08 / 2017:     Kliethermes1
Novelty seeking behavior in 14 inbred strains of mice

08 / 2017:     Maeda1
Genetic architecture of atherosclerosis dissected by QTL analysis in an intercross of apolipoprotein E-null mice on C57BL/6J and DBA/2J backgrounds

08 / 2017:     Shorter1
Male fertility assessment in 347 pre-CC lines of the Collaborative Cross that are now extinct

06 / 2017:     ITP1
Interventions Testing Program: Effects of various treatments on lifespan and related phenotypes in genetically heterogeneous mice (UM-HET3)

06 / 2017:     Sanger4
Sanger SNP and indel data, 89+ million locations, 37 inbred strains of mice

06 / 2017:     UNC-MMUGA2
SNPs for 69 Collaborative Cross strains plus 8 founder strains, 76,000+ locations

05 / 2017:     Rusyn7
Toxicokinetics and toxicodynamics of tetrachloroethylene in males of 45 Collaborative Cross strains of mice

05 / 2017:     Rusyn8
Trichloroethylene exposure in males of 45 Collaborative Cross strains of mice

05 / 2017:     Rusyn9
Impact of nonalcoholic fatty liver disease states on toxicokinetics of tetrachloroethylene exposure in C57BL/6J males

01 / 2017:     Jaxpheno11
Early stages of type 2 diabetes in C57BL/6J male mice on a high-fat diet

01 / 2017:     Schughart3
Susceptibility to influenza A (H3N2) viral infection: body weight and survival at three doses in the 8 inbred founder strains of the Collaborative Cross

01 / 2017:     Schughart4
Susceptibility to influenza A (H3N2) viral infection: body weight, viral loads and leukocyte profiles in females of the 8 inbred founder strains of the Collaborative Cross

01 / 2017:     Schughart5
Susceptibility to influenza A (H3N2) viral infection: body weight and lung weight in females of the 8 inbred founder strains of the Collaborative Cross

01 / 2017:     Tarantino2
Behavioral effects of estrogen depletion in females of 37 inbred strains of mice

09 / 2016:     Jaxpheno10
Atherosclerotic plaques and lipid profiles in non-fasting B6.129P2-Apoetm1Unc/J and B6.129S7-Ldlrtm1Her/J knockout mice

06 / 2016:     Dickson1
Incentive salience to reward cues measured by Pavlovian sign-tracking in 5 inbred founder strains of the Collaborative Cross

06 / 2016:     Dickson2
Novelty-related behaviors and intravenous cocaine self-administration in a Diversity Outbred (DO) mouse population

06 / 2016:     Levy1
Bone microarchitecture in 31 emerging lines of the Collaborative Cross (pre-CC)

05 / 2016:     Gould4
Nicotine-induced conditioned place preference in 8 inbred strains of mice

04 / 2016:     Loos2
Sheltering behavior and locomotor activity in males of 11 inbred strains of mice and within-strain variation of 8 of those strains

04 / 2016:     Mao1
Motor performance and body weight in 16 Collaborative Cross strains of mice

04 / 2016:     Odet1
Male reproduction in 8 inbred founder strains of the Collaborative Cross: Organ weights, testis histology and sperm count, morphology and metabolism

04 / 2016:     Odet2
Male reproduction in 8 inbred founder strains of the Collaborative Cross: Sperm motility

04 / 2016:     Shin1
Observational fear learning, anxiety, locomotor activity, and social behavior in males of 11 inbred strains of mice

04 / 2016:     Vanderlinden1
Drinking in the dark alcohol consumption in 43 ILSXISS recombinant inbred strains of mice

01 / 2016:     Payseur1
Gough Island x WSB intercross to investigate body weight

01 / 2016:     Wiltshire4
Toxicity of four anti-cancer agents tested in vitro in immune cells from 36 inbred mouse strains

09 / 2015:     Nadeau2
Diet effects on body weight and metabolic traits in the C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution panel (males)

09 / 2015:     Reed2
Bone, body composition and taste phenotypes in Monell consomic strains 129P3/J-Chr#C57BL/6ByJ/MonMmjax and C57BL/6ByJ-Chr#129P3/J/MonMmjax

08 / 2015:     Attie1
B6 x BTBR intercross to investigate obesity and diabetes (eQTL study)

08 / 2015:     Tarantino1
Drug study: Initial locomotor sensitivity to cocaine in males of 45 inbred strains of mice

03 / 2015:     Jaxpheno9
Diabetes onset and body weight of NOD/ShiLtJ mice from 3 to 30 weeks of age

03 / 2015:     Trullas1
Locomotor activity and fear-motivated behaviors in 16 strains of mice

02 / 2015:     Morgan1
Drug study: Effects of olanzapine on body weight in 9 inbred strains of mice

10 / 2014:     Chen1
Invariant natural killer T-cells in peripheral blood, spleen, and thymus of 38 inbred strains of mice

07 / 2014:     Kumar1
Reduced complexity cross between C57BL/6J and C57BL/6N substrains for cocaine response, open field and circadian behaviors

06 / 2014:     Harrill1
Drug study: Clinico-pathological survey of the liver and adverse reactions in response to isoniazid treatment in females of 34 inbred strains of mice

06 / 2014:     Hillebrands1
Aging study: Lymphocytic infiltration in kidneys of 23 inbred strains of mice, age 20 months

06 / 2014:     HMDPpheno10
Liver metabolite levels: Nucleotides and peptides in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP)

06 / 2014:     HMDPpheno6
Liver metabolite levels: Amino acids in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP)

06 / 2014:     HMDPpheno7
Liver metabolite levels: Carbohydrates, cofactors and vitamins, energy, and xenobiotics in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP)

06 / 2014:     HMDPpheno8
Liver metabolite levels: Lipids (except lysolipids) in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP)

06 / 2014:     HMDPpheno9
Liver metabolite levels: Lipids (lysolipids) in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP)

06 / 2014:     Loos1
High-throughput phenotyping of avoidance learning in males of 8 inbred strains of mice

06 / 2014:     Rusyn6
Trichloroethylene metabolism and tissue-specific toxicity in males of 7 inbred strains of mice

05 / 2014:     Kielar1
Genotypic characterization of the HeCo mutant mouse model of subcortical heterotopia associated with seizures and behavioral deficits

05 / 2014:     Korstanje2
Aging study: Glomerular mesangial matrix expansion in 29 inbred strains of mice

05 / 2014:     Sandell1
Ear wound healing and articular cartilage regeneration in 6 inbred and 9 LGXSM recombinant inbred strains of mice

04 / 2014:     CGD-MDA2
SNP data from Mouse Diversity Genotyping Array, 470,000+ locations for 92 BXD strains of mice

04 / 2014:     CGD-MDA3
SNP data from Mouse Diversity Genotyping Array, 470,000+ locations for 69 ILSXISS strains of mice



Many other data sets have been released since MPD began in 2001.