Studies from Churchill Group QTL Archive

A collection of QTL studies across populations and species, curated by the Churchill Group to form the QTL Archive (qtlarchive@jax.org). Each study has phenotype and genotype data for members of a population derived from a specific cross, and includes a list of phenotypes, an Excel archive file and a .csv file formatted for use with R/qtl. Most pages include original analysis scripts and other files, and a list of associated MGI-curated genomic features. Users can locate a data set of interest, download the data, and reproduce or extend analyses locally using software such as R/qtl, J/qtl, QTLRel, or DOQTL. Marker locations use Cox build 37 coordinates unless otherwise stated. QTL Archive resource funded by NIH R01 grant GM070683 to Gary Churchill.


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Data set Procedure What's in this data set Strains
Tested
Sex Age Year
Ackerman1 study archive
with methacholine
Lung, respiratory function, baseline and methacholine-challenged (several doses). airway resistance MCh QTL population f 2005
Ankra-Badu1 study archive Body, organ, fat pad weights, weight gain, litter size. subcutaneous, epididymal, liver, kidney, spleen, heart, testis, tail length, L6, M16i None QTL population both 2009
Bailey1 study archive Open field test. Locomotor activity, anxiety-related behavior. None OFT QTL population both 2008
Bautz1 study archive Plasma lipids. Cholesterol, triglycerides. Nsdhl CHOL, TG QTL population both 2013
Beamer1 study archive Bone volume. None None QTL population f 1999
Beamer2 study archive Bone morphology and strength, insulin-like growth factor 1. femur, trabecular spacing, peak maximum ultimate break load, stiffness IGF-1, IGF1, INS QTL population f 2001
Bouma1 study archive Fetal gonads microscopy study. Dax1 None QTL population m 2005
Brich1 study archive Protein tau hyperphosphorylation. axonal microtubule stabilizing, Dab1 cytoplasmic adapter None QTL population f 2003
Brockmann1 study archive Body, organ weights, litter size, abdominal fat, lipids, insulin, leptin. Liver, kidney, muscle weights. Cholesterol, triglycerides, insulin-like growth factor, NMRI8, DU6i CHOL, INS, LEP, TG QTL population both 2009
Broman1 study archive Gut length. Sox10, Sox10Dom None QTL population both 2006
Bubier2 study archive Intestinal microbiome study. microbiota, flora, gut bacteria None QTL population both 2014
Burke1 study archive Femur and vertebra morphology and strength. Monthly body weight 3 - 13 months. None BW QTL population f 2012
Chesler6 study archive
with ethanol
Sensitivity to ethanol. Baseline and ethanol. blood alcohol concentration, loss of righting reflex, rotarod, body temperature. EtOH QTL population both 2012
Clemens1 study archive
with ultraviolet light
Immunosuppression of contact hypersensitivity after ultraviolet light exposure None UV QTL population both 2000
Davidson1 study archive Exencephaly, neural tube defects in embryos. None None QTL population both 2007
DiPetrillo3 study archive Blood pressure (tail cuff), heart rate, heart weight. None BP, HR QTL population both 2004
Doorenbos1 study archive Urinalysis. Creatinine, microalbumin, body weight. kidney, Apoe Alb, BW, CREA, MA QTL population m 2008
Dorward1 study archive Ovarian granulosa cell tumors histopathology. None None QTL population f 2005
Dzur-Gejdosova1 study archive Sterility investigation. Sperm count, testes weight. None None QTL population m 2012
Farmer1 study archive Colitis susceptibility, severity. Colon histopathology, body and spleen weight. cecum, proximal, distal, ulceration, diarrhea, fecal blood, interleukin 10 IL-10, IL-12, IL10, IL12 QTL population both 2001
Feng1 study archive Blood pressure (tail cuff), kidney weight, body weight. None BP, BW QTL population m 2009
Gatti2 study archive Whole blood neutrophil count and white cell count. None None DO population both 2014
Guay-Woodford1 study archive Kidney morphology, renal cystic disease severity. Bicc1jcpk None QTL population f 2000
Hageman1 study archive eQTL, urinary albumin excretion using microarray. creatinine. Alb, CREA QTL population m 2011
Ishimori1 study archive
with high-fat diet
Lipids, atherosclerosis lesions, parathyroid hormone after high-fat diet. None BMD, BMI, LW QTL population f 2004
Jarvis1 study archive Fat pad weight. Epistatic interactions. None None QTL population both 2011
Karst1 study archive Characterization of high-muscle-mass mice. fat, lean, muscle mass, glucose, drip loss, carcass pH, glycogen, lactate, litter size, body weight, coat color, colorimetric assay BW, GLU QTL population both 2011
Kiernan1 study archive Ear microscopy (ampullae) and eye slit lamp study. Jag None QTL population f 2007
Kim1 study archive Glucose, insulin, body and fat pad weights. None GLU, INS QTL population m 2001
Korstanje3 study archive
with high-fat diet
Cholesterol and phospholipid transfer, baseline vs. high-fat diet. None CHOL, PL QTL population both 2004
Kumar1 study archive
with cocaine
Open field test. Locomotor, anxiety-related, circadian behavior. Baseline and after cocaine i.p. None OFT QTL population both 2014
Leiter2 study archive Type 1 diabetes development study. diabetes score, age of onset, insulitis severity, body weight, bone mineral density, content, muscle, organ weights, glucose, insulin, leptin, fat, lean mass, cholesterol, HDL, fatty acids, triglycerides, colorimetric assay, H2g7, T1D BMD, BW, CHOL, FFA, GLU, INS, LEP, TG QTL population f 2009
Li1 study archive
with western diet
Lipids, atherosclerosis lesion histopathology. High-fat, western-style diet. cholesterol, triglycerides, Apoe CHOL, TG QTL population f 2008
Lyons1 study archive
with high-fat diet
Lipids (plasma), liver weight, gallbladder and gallstone histopathology. monohydrate crystals, aggregates LW QTL population m 2003
Lyons2 study archive
with high-fat diet
Lipids (plasma), bile, liver weight, gallbladder and gallstone histopathology. None LW QTL population m 2003
Lyons3 study archive
with high-fat diet
Lipids, gallbladder and gallstone histopathology after high-fat diet. cholesterol, HDL, triglycerides CHOL, TG QTL population m 2004
Lyons4 study archive
with high-fat diet
Gallstone susceptibility. None None QTL population both 2005
Maeda1 study archive Atherosclerosis lesion histopathology, lesion sizes. None None QTL population both 2017
Mahler1 study archive Colitis susceptibility. Colon histopathology, spleen weight. cecum, proximal, distal, ulceration, interleukin 10 IL-10, IL10 QTL population both 2002
Mathews1 study archive Type 1 diabetes resistance. T1DM None QTL population f 2003
Moore1 study archive Gravitropic response in Arabidopsis. arabidopsis, thaliana None QTL population both 2013
Mrug1 study archive Kidney morphology. length, weight, volume None QTL population both 2005
Nishihara1 study archive Blood pressure (tail cuff). systolic, diastolic BP QTL population m 2007
Payseur1 study archive Body weight of Gough Island mice. None BW QTL population both 2015
Peters5 study archive Complete blood count measures on fetuses, newborns. red cell count, hemoglobin, hematocrit, corpuscular volume, concentration CBC, RBC, WBC, CHCM, HCT, HGB, MCH, MCHC QTL population both 2004
Pitman1 study archive
with high-fat diet
Cholesterol (plasma) after high-fat diet (several timepoints). None CHOL QTL population f 2002
Recla1 study archive Hot plate nociception. None HP DO population both 2013
Reifsnyder1 study archive Body weight (several ages), fat mass, body mass index, fat pad weights. inguinal, peritoneal, mesenteric BMI, BW, GLU, INS, TG QTL population m 2000
Reifsnyder2 study archive Type 2 diabetes onset. None None QTL population f 2005
Richards-Smith1 study archive
with macronutrient diet option
Caloric intake, glucose, body and fat pad weights. Macronutrient diet option. retroperitoneal, epididymal, diet choice preference GLU QTL population m 2002
Rodriguez1 study archive Spleen, liver murine cytomegalovirus study. natural killer cell-mediated resistance, antiviral responses MCMV QTL population both 2009
Sheehan1 study archive Urinalysis. Creatinine, microalbumin, body weight. None Alb, BW, CREA, MA QTL population m 2007
Shimomura1 study archive Circadian activity. None None QTL population both 2001
Solberg1 study archive Open field test, forced swim test, defensive burying task. None BW, GLU, INS, OFT QTL population both 2004
Stylianou1 study archive
with high-fat diet
Body size, weight, fat pad weights after high-fat diet. adiposity index None QTL population both 2006
Stylianou2 study archive Lipids. Cholesterol, triglycerides, body weight. None BW, CHOL, TG QTL population both 2006
Su2 study archive
with high-fat diet
Lipids (plasma). Cholesterol, triglycerides, aortic lesions, body mass index. None BMI, CHOL, TG QTL population f 2009
Sugiyama2 study archive
with sodium chloride
Blood pressure (tail cuff) after sodium chloride intake. None BP, NaCl QTL population m 2001
Sugiyama3 study archive Blood pressure (tail cuff), heart weight, body weight. None BP, BW QTL population m 2002
Sundberg2 study archive Alopecia areata autoimmune disease susceptibility. None None QTL population both 2003
Svenson6 study archive Cholesterol investigation. None CHOL QTL population both 2012
Tsaih1 study archive Brain weight, body weight. None BW QTL population both 2005
Wang1 study archive
with high-fat diet
Lipids (plasma). Cholesterol, inducibility, triglycerides, atherosclerosis lesions. None CHOL, TG QTL population f 2003
Wergedal1 study archive Bone mineral density, thickness, strength. peak maximum ultimate break load BMD QTL population f 2006
Wittenburg1 study archive
with high-fat diet
Liver weight, gallbladder and gallstone histopathology. None LW QTL population both 2002
Wittenburg2 study archive
with high-fat diet
Lipids (plasma), liver weight, gallbladder and gallstone histopathology. None LW QTL population both 2003
Wittenburg3 study archive
with high-fat diet
Lipids (plasma), liver weight, gallbladder and gallstone histopathology. None LW QTL population both 2005
Xiong1 study archive Circadian behavior. None None QTL population m 2011
Yi1 study archive Body weight (several timepoints) and liver weight. M16I BW, LW QTL population both 2007
Yuan5 study archive Plasma levels of P-selectin and soluble vascular cell adhesion molecule-1. Apoe None QTL population f 2008
Yuan6 study archive Insulin-like growth factor 1 investigation. None IGF-1, IGF1, INS QTL population both 2013
Zhang1 study archive
with western diet
Atherosclerosis and glucose homeostasis. Lesions, lipids, glucose, insulin. High-fat, western-style diet. apolipoprotein E-deficient mice, Apoe None QTL population f 2012