MPD is collaborating with the replicability group at Tel Aviv University to assess replicability in mouse phenotyping.
We have implemented a statistical approach that treats laboratory as a random variable and measures the effect of the
interaction between experimental group and laboratory. Currently the method is deployed in the context of
Genotype x Laboratory interactions using data from the
International Mouse Phenotyping Consortium
We are in the process of incorporating this tool into the MPD system.
In the meantime, users may access the GxL Replicability Adjuster prototype
We are soliciting members of the community to submit their phenotyping data
to maximize the usefulness of this tool.
Kafkafi N, Golani I, Jaljuli I, Morgan H, Sarig T, Würbel H, Yaacoby S, Benjamini Y. Addressing reproducibility in single-laboratory phenotyping experiments.
Nat Methods. 2017 Apr 27;14(5):462-464. doi: 10.1038/nmeth.4259.