Replicability analysis

MPD is collaborating with the group cited below at Tel Aviv University to assess replicability in mouse phenotyping, utilizing a statistical approach that treats laboratory as a random variable and measures the effect of the interaction between experimental group and laboratory.

Kafkafi N, Golani I, Jaljuli I, Morgan H, Sarig T, Würbel H, Yaacoby S, Benjamini Y. Addressing reproducibility in single-laboratory phenotyping experiments. Nat Methods. 2017 Apr 27;14(5):462-464. doi: 10.1038/nmeth.4259.   PubMed 28448068  

Currently the method is deployed in the context of Genotype x Laboratory interactions using data from the International Mouse Phenotyping Consortium. We are in the process of incorporating this tool into the MPD system. In the meantime, users may access the GxL Replicability Analysis prototype here at the Tel Aviv University site.