MPD: Data set: CSNA03

CSNA03: Behavioral phenotypes on cocaine self-administration, acute drug response, impulsivity, reward seeking, and circadian dysregulation in Collaborative Cross strains of mice, Diversity Outbred mice, and their 8 founder inbred strains (2021)

Chesler EJ, Gagnon L, Jentsch JD, Logan RW, Philip VM, Reinholdt L, Tarantino LM, Wilcox T With: Roy T, Wilcox T, Olsen A, Caldwell S, Datta U, Kim SM, Bagley J, Bailey L, Dickson PE, He H, Gargano M, Dunn M, Dionne L, Olivier C

Procedures conducted:

• open field test		Distance traveled, habituation ratio, number of rears, ambulatory time, time in perimeter, corners, and center; cocaine sensitization.
• light-dark box		Distance traveled, ambulatory time and counts, resting time, stereotypic time and counts, jumping time and counts, vertical time and counts, time in light/dark.
• hole board test		Number of entries, novel entries, and repeat entries.
• conditioned place preference test		In novel zone: exploration counts, entrance counts, time spent, activity counts, movement counts.
• operant conditioning chamber		Number of infusions, active lever presses, inactive lever presses, intravenous self administration, reversal learning.
• in vitro assay		Circadian parameters in fibroblast cultures: period, amplitude, phase, damping rate, goodness of fit.

CSNA03 downloads
• Download CSNA03 project data set animal data, as uploaded
• Download CSNA03 animal data matrix with factor-related expansion applied as necessary
• Download CSNA03 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to CSNA03 measures:

MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0001408 stereotypic behavior
MP:0001988 cocaine preference
MP:0002063 abnormal learning/memory/conditioning
MP:0002803 abnormal operant conditioning behavior
MP:0003107 abnormal response to novelty
MP:0010698 abnormal impulsive behavior control
MP:0013189 abnormal exploration in a new environment
MP:0020158 abnormal behavioral response to cocaine
MP:0020414 abnormal fibroblast physiology
MP:0020467 abnormal circadian behavior
MP:0020895 abnormal acute locomotor response to cocaine
MP:0020896 abnormal locomotor sensitization to cocaine
MP:0020897 abnormal initiation of locomotor sensitization to cocaine
MP:0020898 abnormal expression of locomotor sensitization to cocaine
MP:0020899 abnormal cocaine conditioned locomotor activation
VT:0001392 locomotor behavior trait
VT:0002063 learning/memory/conditioning trait
VT:0010455 rhythmic behavior trait
VT:0010459 behavioral response to novel environment trait
VT:0010471 exploratory behavior trait
VT:0010473 impulsivity behavior trait
VT:0010531 operant conditioning behavior trait
VT:0010716 anxiety-related behavior trait
VT:0010718 response to cocaine trait
VT:0010748 stereotypic behavior trait

Investigators	Elissa J Chesler The Jackson Laboratory, Bar Harbor, ME Leona Gagnon The Jackson Laboratory, Bar Harbor, ME J D Jentsch Binghamton University, Binghamton, NY Ryan W Logan The Jackson Laboratory, Bar Harbor, ME Vivek M Philip The Jackson Laboratory, Bar Harbor, ME Laura Reinholdt The Jackson Laboratory, Bar Harbor, ME Lisa M Tarantino University of North Carolina, Chapel Hill, NC Troy Wilcox
Participants	Roy T, Wilcox T, Olsen A, Caldwell S, Datta U, Kim SM, Bagley J, Bailey L, Dickson PE, He H, Gargano M, Dunn M, Dionne L, Olivier C
Contact	Elissa J Chesler elissa.chesler@jax.org Lab web site
Affiliated Center	Center for Systems Neurogenetics of Addiction (CSNA)
Project type	Phenotype strain survey data set
MPD identifiers	CSNA03 MPD:626
Data changelog	2 updates/corrections. Initial release date: 02/2022.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Mice: CC w/CC8 63 strains ♀♂ age 4-25wks

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
CSNA03:1	CSNA03	open field test	(none)	total distance traveled, 60 min test (OFT), founders [cm] dist_OFT_in 90001	inbred w/CC8	10	both	4-14wks	N=43

CSNA03:2	CSNA03	open field test	(none)	total distance traveled, 60 min test (OFT), CC [cm] dist_OFT_cc 90002	CC w/par	59	both	4-19wks	N=18

CSNA03:3	CSNA03	open field test	(none)	total distance traveled, 60 min test (OFT), DO [cm] dist_OFT_do 90003	DO population w/par	9	both	4-25wks	N=202

CSNA03:4	CSNA03	open field test	(none)	distance traveled in perimeter and corners, 60 min test (OFT), founders [cm] dist_perimeter_corners_OFT_in 90004	inbred w/CC8	10	both	4-14wks	N=43

CSNA03:5	CSNA03	open field test	(none)	distance traveled in perimeter and corners, 60 min test (OFT), CC [cm] dist_perimeter_corners_OFT_cc 90005	CC w/par	59	both	4-19wks	N=18

CSNA03:6	CSNA03	open field test	(none)	distance traveled in perimeter and corners, 60 min test (OFT), DO [cm] dist_perimeter_corners_OFT_do 90006	DO population w/par	9	both	4-25wks	N=202

CSNA03:7	CSNA03	open field test	(none)	distance traveled in perimeter, 60 min test (OFT), founders [cm] dist_perimeter_OFT_in 90007	inbred w/CC8	10	both	4-14wks	N=43

CSNA03:8	CSNA03	open field test	(none)	distance traveled in perimeter, 60 min test (OFT), CC [cm] dist_perimeter_OFT_cc 90008	CC w/par	59	both	4-19wks	N=18

CSNA03:9	CSNA03	open field test	(none)	distance traveled in perimeter, 60 min test (OFT), DO [cm] dist_perimeter_OFT_do 90009	DO population w/par	9	both	4-25wks	N=202

CSNA03:10	CSNA03	open field test	(none)	distance traveled in corners, 60 min test (OFT), founders [cm] dist_corners_OFT_in 90010	inbred w/CC8	10	both	4-14wks	N=43

CSNA03:11	CSNA03	open field test	(none)	distance traveled in corners, 60 min test (OFT), CC [cm] dist_corners_OFT_cc 90011	CC w/par	59	both	4-19wks	N=18

CSNA03:12	CSNA03	open field test	(none)	distance traveled in corners, 60 min test (OFT), DO [cm] dist_corners_OFT_do 90012	DO population w/par	9	both	4-25wks	N=202

CSNA03:13	CSNA03	open field test	(none)	percentage of total distance traveled in center, 60 min test (OFT), founders [%] pct_dist_center_OFT_in 90013	inbred w/CC8	10	both	4-14wks	N=43

CSNA03:14	CSNA03	open field test	(none)	percentage of total distance traveled in center, 60 min test (OFT), CC [%] pct_dist_center_OFT_cc 90014	CC w/par	59	both	4-19wks	N=18

CSNA03:15	CSNA03	open field test	(none)	percentage of total distance traveled in center, 60 min test (OFT), DO [%] pct_dist_center_OFT_do 90015	DO population w/par	9	both	4-25wks	N=202

CSNA03:16	CSNA03	open field test	(none)	distance traveled slope, 60 min test (OFT), founders dist_slope_OFT_in 90016	inbred w/CC8	10	both	4-14wks	N=43

CSNA03:17	CSNA03	open field test	(none)	distance traveled slope, 60 min test (OFT), CC dist_slope_OFT_cc 90017	CC w/par	59	both	4-19wks	N=18

CSNA03:18	CSNA03	open field test	(none)	distance traveled slope, 60 min test (OFT), DO dist_slope_OFT_do 90018	DO population w/par	9	both	4-25wks	N=202

CSNA03:19	CSNA03	open field test	(none)	distance traveled in successive 5 min intervals, 60 min test (OFT), founders [cm] amb_dist_OFT_in 90019 min: 0-5 5-10 10-15 15-20 20-25 25-30 30-35 35-40 40-45 45-50 50-55 55-60	inbred w/CC8	10	both	4-14wks	N=43

CSNA03:31	CSNA03	open field test	(none)	distance traveled in successive 5 min intervals, 60 min test (OFT), CC [cm] amb_dist_OFT_cc 90020 min: 0-5 5-10 10-15 15-20 20-25 25-30 30-35 35-40 40-45 45-50 50-55 55-60	CC w/par	59	both	4-19wks	N=18

CSNA03: Behavioral phenotypes on cocaine self-administration, acute drug response, impulsivity, reward seeking, and circadian dysregulation in Collaborative Cross strains of mice, Diversity Outbred mice, and their 8 founder inbred strains (2021)

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