Project measure / variable:   CSNA03   acquisition_in

ID, description, units MPD:110188   acquisition_in   number of sessions to acquisition (1.0 mg/kg) (intravenous self administration), founders   [n]  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age: 4-25wks
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - number of sessions to acquisition (1.0 mg/kg) (intravenous self administration), founders



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means9.9809   n 9.3821   n
Median of the strain means9.1538   n 7.5556   n
SD of the strain means± 2.696 ± 2.8003
Coefficient of variation (CV)0.2701 0.2985
Min–max range of strain means6.4615   –   13.2   n 7.1818   –   14.125   n
Mean sample size per strain10.7   mice 9.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5.4295 5.4295 0.1872 0.666
strain 6 802.2516 133.7086 4.6092 0.0003
sex:strain 6 51.7888 8.6315 0.2975 0.9371
Residuals 126 3655.1801 29.0094


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 12.667 7.2405   12 2.0901 0.5716 5.0, 28.0 1.0
A/J m 12.333 6.6895   9 2.2298 0.5424 5.0, 24.0 1.05
C57BL/6J f 12.077 7.6427   13 2.1197 0.6328 5.0, 27.0 0.78
C57BL/6J m 9.6154 4.9756   13 1.38 0.5175 5.0, 24.0 0.08
CAST/EiJ f 9.125 4.8237   8 1.7054 0.5286 5.0, 20.0 -0.32
CAST/EiJ m 7.5 1.0   4 0.5 0.1333 6.0, 8.0 -0.67
NOD/ShiLtJ f 9.1538 5.942   13 1.648 0.6491 5.0, 21.0 -0.31
NOD/ShiLtJ m 7.5556 2.0683   9 0.68943 0.2737 5.0, 11.0 -0.65
NZO/HlLtJ f 6.4615 2.367   13 0.65648 0.3663 5.0, 13.0 -1.31
NZO/HlLtJ m 7.1818 1.7215   11 0.51906 0.2397 5.0, 10.0 -0.79
PWK/PhJ f 7.1818 2.7502   11 0.82922 0.3829 5.0, 14.0 -1.04
PWK/PhJ m 7.3636 3.1709   11 0.95606 0.4306 5.0, 14.0 -0.72
WSB/EiJ f 13.2 9.0664   5 4.0546 0.6869 5.0, 27.0 1.19
WSB/EiJ m 14.125 8.4251   8 2.9787 0.5965 5.0, 27.0 1.69


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 12.6666666667 1.5548141971 15.7435982543 9.589735079
A/J m 12.3333333333 1.7953447905 15.8862678942 8.7803987725
C57BL/6J f 12.0769230769 1.4938171614 15.033143324 9.1207028298
C57BL/6J m 9.6153846154 1.4938171614 12.5716048625 6.6591643683
CAST/EiJ f 9.125 1.9042507139 12.8934561816 5.3565438184
CAST/EiJ m 7.5 2.6930171858 12.8294018413 2.1705981587
NOD/ShiLtJ f 9.1538461538 1.4938171614 12.110066401 6.1976259067
NOD/ShiLtJ m 7.5555555556 1.7953447905 11.1084901164 4.0026209947
NZO/HlLtJ f 6.4615384615 1.4938171614 9.4177587086 3.5053182144
NZO/HlLtJ m 7.1818181818 1.6239504653 10.3955684117 3.9680679519
PWK/PhJ f 7.1818181818 1.6239504653 10.3955684117 3.9680679519
PWK/PhJ m 7.3636363636 1.6239504653 10.5773865935 4.1498861337
WSB/EiJ f 13.2 2.4087077968 17.9667619186 8.4332380814
WSB/EiJ m 14.125 1.9042507139 17.8934561816 10.3565438184


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 12.5 1.1875089583 14.8500453181 10.1499546819
C57BL/6J both 10.8461538462 1.0562882447 12.9365172296 8.7557904627
CAST/EiJ both 8.3125 1.6491294934 11.5760787863 5.0489212137
NOD/ShiLtJ both 8.3547008547 1.1677705927 10.6656845275 6.0437171819
NZO/HlLtJ both 6.8216783217 1.1032570899 9.004991669 4.6383649744
PWK/PhJ both 7.2727272727 1.1483063863 9.5451918533 5.0002626921
WSB/EiJ both 13.6625 1.5352560073 16.7007265049 10.6242734951




  GWAS USING LINEAR MIXED MODELS