Project measure / variable:   CSNA03   dist_d5_d3_cocaine_in

ID, description, units MPD:90313   dist_d5_d3_cocaine_in   distance traveled, last 60 min (post-injection), Day 5 (cocaine) minus Day 3 (cocaine), cocaine sensitization, founders   [cm]  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), Day 5 (cocaine) minus Day 3 (cocaine), cocaine sensitization, founders



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means2573.0   cm 1944.0   cm
Median of the strain means1286.0   cm 1491.0   cm
SD of the strain means± 3860.0 ± 4258.0
Coefficient of variation (CV)1.5003 2.1908
Min–max range of strain means-1187.0   –   11818.0   cm -5014.0   –   11863.0   cm
Mean sample size per strain6.0   mice 6.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5098898.726 5098898.726 0.1273 0.7219
strain 8 699809783.8852 87476222.9856 2.1847 0.0344
sex:strain 8 699519910.6188 87439988.8274 2.1838 0.0345
Residuals 104 4164258340.3053 40040945.5799


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 984.8 2284.0   6 932.5 2.3192 -37.988, 5643.0 -0.41
129S1/SvImJ m -137.3 1202.0   6 490.5 -8.7491 -1102.0, 1863.0 -0.49
A/J f -1187.0 1771.0   12 511.3 -1.492 -4962.0, 797.5 -0.97
A/J m 370.3 2004.0   12 578.5 5.4113 -2414.0, 4865.0 -0.37
C57BL/6J f 977.1 8284.0   5 3705.0 8.4789 -12896.0, 8347.0 -0.41
C57BL/6J m 2554.0 5471.0   7 2068.0 2.142 -3846.0, 11593.0 0.14
C57BL/6NJ f -688.4 0.0   1   0.0 0.0 -688.4, -688.4 -0.84
C57BL/6NJ m 247.4 0.0   1   0.0 0.0 247.4, 247.4 -0.4
CAST/EiJ f -76.83 5176.0   6 2113.0 -67.3681 -7734.0, 7419.0 -0.69
CAST/EiJ m 11863.0 8928.0   5 3993.0 0.7526 3333.0, 24960.0 2.33
DBA/2J f 11818.0 5430.0   2   3840.0 0.4595 7978.0, 15657.0 2.39
DBA/2J m 4170.0 8172.0   4 4086.0 1.9595 -3440.0, 12971.0 0.52
NOD/ShiLtJ f 4528.0 5399.0   6 2204.0 1.1923 -1353.0, 14414.0 0.51
NOD/ShiLtJ m 2097.0 6276.0   6 2562.0 2.9922 -5214.0, 11883.0 0.04
NZO/HlLtJ f 2569.0 2932.0   6 1197.0 1.1414 -191.4, 7502.0 0.0
NZO/HlLtJ m 885.0 2976.0   7 1125.0 3.3622 -4290.0, 5502.0 -0.25
PWK/PhJ f 5219.0 9426.0   9 3142.0 1.8062 -3431.0, 24918.0 0.69
PWK/PhJ m 2400.0 7183.0   9 2394.0 2.9935 -11545.0, 11885.0 0.11
WSB/EiJ f 1587.0 13243.0   7 5005.0 8.3445 -19470.0, 22225.0 -0.26
WSB/EiJ m -5014.0 7083.0   7 2677.0 -1.4126 -15003.0, 6913.0 -1.63


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 984.8361666667 2583.3100723639 6107.6369827076 -4137.9646493742
129S1/SvImJ m -137.3333333333 2583.3100723638 4985.4674827076 -5260.1341493742
A/J f -1187.175 1826.676070076 2435.1921956905 -4809.5421956905
A/J m 370.3431666667 1826.676070076 3992.7103623572 -3252.0240290238
C57BL/6J f 977.06 2829.874399328 6588.8071291029 -4634.687129103
C57BL/6J m 2553.9571428571 2391.6803889393 7296.749105479 -2188.8348197647
CAST/EiJ f -76.8333333334 2583.3100723638 5045.9674827075 -5199.6341493743
CAST/EiJ m 11863.4 2829.874399328 17475.147129103 6251.6528708971
DBA/2J f 11817.5 4474.4242970386 20690.4512904382 2944.5487095619
DBA/2J m 4170.5 3163.8957623419 10444.6240266068 -2103.6240266067
NOD/ShiLtJ f 4528.5 2583.3100723638 9651.3008160409 -594.3008160409
NOD/ShiLtJ m 2097.2833333333 2583.3100723638 7220.0841493742 -3025.5174827076
NZO/HlLtJ f 2568.7666666667 2583.3100723638 7691.5674827076 -2554.0341493742
NZO/HlLtJ m 885.0 2391.6803889393 5627.7919626219 -3857.7919626219
PWK/PhJ f 5218.6666666667 2109.2638415612 9401.4160177378 1035.9173155955
PWK/PhJ m 2399.5333333333 2109.2638415612 6582.2826844045 -1783.2160177378
WSB/EiJ f 1587.0 2391.6803889393 6329.7919626219 -3155.7919626219
WSB/EiJ m -5014.2571428571 2391.6803889393 -271.4651802352 -9757.049105479


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 423.7514166667 1826.676070076 4046.1186123572 -3198.6157790238
A/J both -408.4159166667 1291.6550361819 2152.9844913538 -2969.8163246871
C57BL/6J both 1765.5085714286 1852.5876631626 5439.2594285808 -1908.2422857236
CAST/EiJ both 5893.2833333333 1915.8340250364 9692.4540994948 2094.1125671718
DBA/2J both 7994.0 2740.014105114 13427.5507935358 2560.4492064643
NOD/ShiLtJ both 3312.8916666667 1826.676070076 6935.2588623572 -309.4755290238
NZO/HlLtJ both 1726.8833333333 1760.2291053165 5217.4837043849 -1763.7170377182
PWK/PhJ both 3809.1 1491.4747656795 6766.750430146 851.449569854
WSB/EiJ both -1713.6285714286 1691.1734214499 1640.0317870984 -5067.2889299556




  GWAS USING LINEAR MIXED MODELS