Project measure / variable:   CSNA03   dist_d19_d11_cocaine_in

ID, description, units MPD:90325   dist_d19_d11_cocaine_in   distance traveled, last 60 min (post-injection), Day 19 (cocaine) minus Day 11 (cocaine), cocaine sensitization, founders   [cm]  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), Day 19 (cocaine) minus Day 11 (cocaine), cocaine sensitization, founders



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means-278.0   cm 1797.0   cm
Median of the strain means-1307.0   cm 965.7   cm
SD of the strain means± 4741.0 ± 3153.0
Coefficient of variation (CV)-17.0538 1.7542
Min–max range of strain means-5308.0   –   6950.0   cm -1070.0   –   7825.0   cm
Mean sample size per strain5.8   mice 6.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 23416174.5981 23416174.5981 0.3104 0.5787
strain 8 400173878.684 50021734.8355 0.663 0.7228
sex:strain 8 1318101078.7947 164762634.8493 2.1837 0.0347
Residuals 102 7695971895.1958 75450704.8549


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 1716.0 3809.0   5 1703.0 2.2196 0.42
129S1/SvImJ m 72.79 900.2   6 367.5 12.3658 -1025.0, 1516.0 -0.55
A/J f 6950.0 19838.0   11 5981.0 2.8546 -4553.0, 66286.0 1.52
A/J m -653.6 2421.0   12 699.0 -3.7045 -5541.0, 3554.0 -0.78
C57BL/6J f 4184.0 1966.0   5 879.2 0.4698 2239.0, 7200.0 0.94
C57BL/6J m 403.4 4558.0   7 1723.0 11.2972 -7341.0, 4993.0 -0.44
C57BL/6NJ f -5308.0 0.0   1   0.0 0.0 -5308.0, -5308.0 -1.06
C57BL/6NJ m -1070.0 0.0   1   0.0 0.0 -1070.0, -1070.0 -0.91
CAST/EiJ f 6070.0 9001.0   6 3675.0 1.4829 -4234.0, 20031.0 1.34
CAST/EiJ m 1679.0 13430.0   5 6006.0 8.0006 -19353.0, 18076.0 -0.04
DBA/2J f -5054.0 3858.0   3 2227.0 -0.7633 -7453.0, -603.8 -1.01
DBA/2J m 7825.0 9357.0   4 4679.0 1.1958 -6143.0, 13579.0 1.91
NOD/ShiLtJ f -236.3 3735.0   6 1525.0 -15.8031 -4780.0, 4924.0 0.01
NOD/ShiLtJ m 1959.0 1608.0   6 656.6 0.821 -759.0, 3538.0 0.05
NZO/HlLtJ f -2378.0 4735.0   5 2117.0 -1.9913 -10346.0, 1516.0 -0.44
NZO/HlLtJ m -783.8 2305.0   7 871.2 -2.9409 -3862.0, 2842.0 -0.82
PWK/PhJ f -4478.0 7770.0   9 2590.0 -1.7352 -15402.0, 4764.0 -0.89
PWK/PhJ m 1528.0 8704.0   9 2901.0 5.6963 -10054.0, 18110.0 -0.09
WSB/EiJ f -4246.0 9690.0   7 3662.0 -2.2824 -20720.0, 8304.0 -0.84
WSB/EiJ m 7014.0 6030.0   7 2279.0 0.8597 -2620.0, 16431.0 1.65


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 1716.16 3884.6030647895 9421.2517604089 -5988.9317604088
129S1/SvImJ m 72.7933333333 3546.1412092316 7106.5476080386 -6960.9609413719
A/J f 6949.5018181818 2618.9988520054 12144.2736233161 1754.7300130475
A/J m -653.6083333333 2507.5004960927 4320.0070115106 -5627.2236781773
C57BL/6J f 4184.4 3884.6030647895 11889.4917604089 -3520.6917604089
C57BL/6J m 403.4285714286 3283.0888081383 6915.4196558118 -6108.5625129546
CAST/EiJ f 6070.1666666667 3546.1412092315 13103.9209413719 -963.5876080385
CAST/EiJ m 1678.6 3884.6030647895 9383.6917604088 -6026.4917604089
DBA/2J f -5053.6 5015.0009921854 4893.6306896878 -15000.8306896878
DBA/2J m 7825.25 4343.1182592367 16439.8044745739 -789.3044745739
NOD/ShiLtJ f -236.3333333333 3546.1412092315 6797.4209413719 -7270.0876080385
NOD/ShiLtJ m 1958.8333333333 3546.1412092315 8992.5876080385 -5074.9209413719
NZO/HlLtJ f -2377.8024 3884.6030647895 5327.2893604089 -10082.8941604089
NZO/HlLtJ m -783.7714285714 3283.0888081383 5728.2196558118 -7295.7625129546
PWK/PhJ f -4478.2333333333 2895.4121728245 1264.8029830493 -10221.2696497159
PWK/PhJ m 1528.0666666667 2895.4121728245 7271.1029830492 -4214.9696497159
WSB/EiJ f -4245.5 3283.0888081383 2266.4910843832 -10757.4910843832
WSB/EiJ m 7013.5714285714 3283.0888081383 13525.5625129546 501.5803441882


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 894.4766666667 2629.8887070931 6110.8484477338 -4321.8951144005
A/J both 3147.9467424242 1812.9198634186 6743.8646956695 -447.971210821
C57BL/6J both 2293.9142857143 2543.0696556079 7338.0808898077 -2750.2523183792
CAST/EiJ both 3874.3833333333 2629.8887070931 9090.7551144005 -1341.9884477338
DBA/2J both 1385.825 3317.1113625162 7965.2996596759 -5193.6496596759
NOD/ShiLtJ both 861.25 2507.5004960927 5834.8653448439 -4112.3653448439
NZO/HlLtJ both -1580.7869142857 2543.0696556079 3463.3796898077 -6624.9535183792
PWK/PhJ both -1475.0833333333 2047.3655817343 2585.8565905814 -5536.0232572481
WSB/EiJ both 1384.0357142857 2321.4943594723 5988.7087690794 -3220.637340508




  GWAS USING LINEAR MIXED MODELS