Project measure / variable:   CSNA03   dist_d12_d2_cocaine_in

ID, description, units MPD:90319   dist_d12_d2_cocaine_in   distance traveled, last 60 min (post-injection), Day 12 (saline) minus Day 2 (saline), cocaine sensitization, founders   [cm]  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), Day 12 (saline) minus Day 2 (saline), cocaine sensitization, founders



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means600.3   cm 1978.0   cm
Median of the strain means472.6   cm 1206.0   cm
SD of the strain means± 1478.0 ± 1471.0
Coefficient of variation (CV)2.4627 0.7439
Min–max range of strain means-2027.0   –   3473.0   cm 721.5   –   4506.0   cm
Mean sample size per strain6.0   mice 6.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 27341369.3028 27341369.3028 1.126 0.2912
strain 8 114723603.878 14340450.4847 0.5906 0.7836
sex:strain 8 66874508.3654 8359313.5457 0.3443 0.9464
Residuals 100 2428251783.089 24282517.8309


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 361.0 871.7   6 355.9 2.4146 -12.7, 2140.0 -0.16
129S1/SvImJ m 816.9 1665.0   6 679.7 2.0381 -485.9, 4089.0 -0.79
A/J f 584.1 1019.0   12 294.0 1.7439 -978.6, 2218.0 -0.01
A/J m 1024.0 1719.0   11 518.2 1.6782 -976.3, 5486.0 -0.65
C57BL/6J f 1964.0 1623.0   5 726.0 0.8266 -45.03, 3345.0 0.92
C57BL/6J m 1148.0 4182.0   6 1707.0 3.6415 -3333.0, 8355.0 -0.56
C57BL/6NJ f -2027.0 0.0   1   0.0 0.0 -2027.0, -2027.0 -1.78
C57BL/6NJ m 1586.0 0.0   1   0.0 0.0 1586.0, 1586.0 -0.27
CAST/EiJ f 3473.0 10033.0   6 4096.0 2.8887 -9680.0, 17484.0 1.94
CAST/EiJ m 3660.0 3326.0   5 1487.0 0.9087 -1384.0, 7766.0 1.14
DBA/2J f 340.9 2692.0   3 1554.0 7.8975 -2275.0, 3103.0 -0.18
DBA/2J m 4506.0 4639.0   4 2320.0 1.0296 424.6, 10927.0 1.72
NOD/ShiLtJ f 232.9 6543.0   6 2671.0 28.101 -8628.0, 9414.0 -0.25
NOD/ShiLtJ m 4021.0 10648.0   6 4347.0 2.6483 -5675.0, 21155.0 1.39
NZO/HlLtJ f 1118.0 506.9   6 207.0 0.4535 509.8, 1811.0 0.35
NZO/HlLtJ m 721.5 421.3   7 159.2 0.5839 205.4, 1230.0 -0.85
PWK/PhJ f -845.2 6005.0   8 2123.0 -7.1046 -8479.0, 8661.0 -0.98
PWK/PhJ m 1263.0 7177.0   7 2713.0 5.6848 -10192.0, 8872.0 -0.49
WSB/EiJ f 801.7 6561.0   7 2480.0 8.1841 -4129.0, 14892.0 0.14
WSB/EiJ m 1031.0 2640.0   7 997.7 2.5608 -2613.0, 4230.0 -0.64


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 361.0076666667 2011.7371361956 4352.2368476348 -3630.2215143015
129S1/SvImJ m 816.9333333333 2011.7371361956 4808.1625143015 -3174.2958476348
A/J f 584.094 1422.5129709687 3406.3192191322 -2238.1312191322
A/J m 1024.1463636364 1485.7663413168 3971.8644679899 -1923.5717407172
C57BL/6J f 1963.874 2203.7476185303 6336.0465091783 -2408.2985091783
C57BL/6J m 1148.3333333333 2011.7371361956 5139.5625143015 -2842.8958476348
CAST/EiJ f 3473.3333333333 2011.7371361956 7464.5625143015 -517.8958476348
CAST/EiJ m 3660.2 2203.7476185303 8032.3725091782 -711.9725091782
DBA/2J f 340.8666666667 2845.0259419374 5985.3171049311 -5303.5837715977
DBA/2J m 4505.9 2463.8647401435 9394.1374699392 -382.3374699392
NOD/ShiLtJ f 232.85 2011.7371361956 4224.0791809681 -3758.3791809681
NOD/ShiLtJ m 4020.8333333333 2011.7371361956 8012.0625143015 29.6041523652
NZO/HlLtJ f 1117.75 2011.7371361956 5108.9791809682 -2873.4791809682
NZO/HlLtJ m 721.4714285714 1862.5066761487 4416.6316271105 -2973.6887699676
PWK/PhJ f -845.25 1742.2154656819 2611.2558630442 -4301.7558630442
PWK/PhJ m 1262.5714285714 1862.5066761487 4957.7316271105 -2432.5887699676
WSB/EiJ f 801.7142857143 1862.5066761487 4496.8744842533 -2893.4459128248
WSB/EiJ m 1030.8571428571 1862.5066761487 4726.0173413962 -2664.3030556819


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 588.9705 1422.5129709687 3411.1957191322 -2233.2547191322
A/J both 804.1201818182 1028.4751787919 2844.5856440497 -1236.3452804134
C57BL/6J both 1556.1036666667 1491.9441905888 4516.0784480215 -1403.8711146881
CAST/EiJ both 3566.7666666667 1491.9441905888 6526.7414480215 606.7918853119
DBA/2J both 2423.3833333333 1881.8077789734 6156.8363701526 -1310.069703486
NOD/ShiLtJ both 2126.8416666667 1422.5129709687 4949.0668857989 -695.3835524655
NZO/HlLtJ both 919.6107142857 1370.7677979737 3639.1749839748 -1799.9535554034
PWK/PhJ both 208.6607142857 1275.1711500383 2738.5639572046 -2321.2425286332
WSB/EiJ both 916.2857142857 1316.99110071 3529.1585482433 -1696.5871196719




  GWAS USING LINEAR MIXED MODELS