Project measure / variable:   CSNA03   dist_d3_d2_cocaine_in

ID, description, units MPD:90307   dist_d3_d2_cocaine_in   distance traveled, last 60 min (post-injection), Day 3 (cocaine) minus Day 2 (saline), cocaine sensitization, founders   [cm]  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), Day 3 (cocaine) minus Day 2 (saline), cocaine sensitization, founders



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means6424.0   cm 8719.0   cm
Median of the strain means3839.0   cm 7975.0   cm
SD of the strain means± 6833.0 ± 7541.0
Coefficient of variation (CV)1.0637 0.8649
Min–max range of strain means-154.6   –   21081.0   cm -1074.0   –   19738.0   cm
Mean sample size per strain6.0   mice 6.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 143943575.5892 143943575.5892 2.4459 0.1209
strain 8 4858044884.9317 607255610.6165 10.3184 < 0.0001
sex:strain 8 932623024.6236 116577878.0779 1.9809 0.0562
Residuals 102 6002861533.8946 58851583.6656


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3025.0 7279.0   6 2972.0 2.4066 -12.7, 17882.0 -0.5
129S1/SvImJ m 1762.0 1971.0   6 804.8 1.1188 -80.83, 5622.0 -0.92
A/J f 1295.0 2907.0   12 839.2 2.2446 -2656.0, 8556.0 -0.75
A/J m 170.8 917.7   11 276.7 5.3716 -1614.0, 1668.0 -1.13
C57BL/6J f 2917.0 860.2   5 384.7 0.2949 1958.0, 4181.0 -0.51
C57BL/6J m 5532.0 2978.0   6 1216.0 0.5383 2806.0, 11086.0 -0.42
C57BL/6NJ f 1324.0 0.0   1   0.0 0.0 1324.0, 1324.0 -0.75
C57BL/6NJ m -1074.0 0.0   1   0.0 0.0 -1074.0, -1074.0 -1.3
CAST/EiJ f 15317.0 15350.0   6 6267.0 1.0022 -922.1, 42272.0 1.3
CAST/EiJ m 10418.0 8445.0   5 3777.0 0.8106 1358.0, 22148.0 0.23
DBA/2J f -154.6 1323.0   2   935.3 -8.5534 -1090.0, 780.7 -0.96
DBA/2J m 12907.0 8936.0   4 4468.0 0.6924 1263.0, 20185.0 0.56
NOD/ShiLtJ f 6426.0 5870.0   6 2396.0 0.9136 378.6, 16752.0 0.0
NOD/ShiLtJ m 13806.0 13296.0   6 5428.0 0.9631 -122.1, 38411.0 0.67
NZO/HlLtJ f 4653.0 2653.0   6 1083.0 0.5703 1587.0, 7735.0 -0.26
NZO/HlLtJ m 5055.0 5245.0   7 1982.0 1.0376 1295.0, 13198.0 -0.49
PWK/PhJ f 8359.0 9010.0   9 3003.0 1.0778 -845.0, 25100.0 0.28
PWK/PhJ m 19738.0 11605.0   9 3868.0 0.588 -2685.0, 34795.0 1.46
WSB/EiJ f 21081.0 8304.0   7 3139.0 0.3939 7111.0, 30795.0 2.14
WSB/EiJ m 18871.0 8832.0   7 3338.0 0.468 11225.0, 34135.0 1.35


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3024.595 3131.8680172711 9236.6403627019 -3187.4503627019
129S1/SvImJ m 1761.9283333333 3131.8680172711 7973.9736960353 -4450.1170293686
A/J f 1295.05 2214.5651127937 5687.629401005 -3097.529401005
A/J m 170.836 2313.0378227783 4758.7355543574 -4417.0635543574
C57BL/6J f 2917.4 3430.7895203767 9722.3547467944 -3887.5547467944
C57BL/6J m 5532.0 3131.8680172711 11744.0453627019 -680.0453627019
CAST/EiJ f 15317.15 3131.8680172711 21529.1953627019 9105.1046372981
CAST/EiJ m 10417.6 3430.7895203767 17222.5547467944 3612.6452532056
DBA/2J f -154.65 5424.5545285135 10604.9281871224 -10914.2281871224
DBA/2J m 12906.75 3835.7392920281 20514.9206988211 5298.5793011789
NOD/ShiLtJ f 6425.6 3131.8680172711 12637.6453627019 213.5546372981
NOD/ShiLtJ m 13806.4833333334 3131.8680172711 20018.5286960353 7594.4379706314
NZO/HlLtJ f 4652.6666666667 3131.8680172711 10864.7120293686 -1559.3786960352
NZO/HlLtJ m 5055.0 2899.5463602244 10806.2364574883 -696.2364574883
PWK/PhJ f 8358.8444444445 2557.1595280187 13430.9582436585 3286.7306452304
PWK/PhJ m 19738.0 2557.1595280187 24810.1137992141 14665.886200786
WSB/EiJ f 21081.2857142857 2899.5463602244 26832.522171774 15330.0492567974
WSB/EiJ m 18871.0 2899.5463602244 24622.2364574883 13119.7635425117


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 2393.2616666667 2214.5651127937 6785.8410676717 -1999.3177343383
A/J both 732.943 1601.1279312102 3908.772659908 -2442.886659908
C57BL/6J both 4224.7 2322.6554851469 8831.676142064 -382.276142064
CAST/EiJ both 12867.375 2322.6554851469 17474.3511420639 8260.398857936
DBA/2J both 6376.05 3321.8476691905 12964.9191015075 -212.8191015074
NOD/ShiLtJ both 10116.0416666667 2214.5651127937 14508.6210676717 5723.4622656617
NZO/HlLtJ both 4853.8333333333 2134.0083395278 9086.6287565203 621.0379101464
PWK/PhJ both 14048.4222222222 1808.1848428378 17634.9482845964 10461.8961598481
WSB/EiJ both 19976.1428571429 2050.2888936794 24042.8811564402 15909.4045578456




  GWAS USING LINEAR MIXED MODELS