MPD: Phenotype measures mapped to MA:0000358, liver

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Ankra-Badu1:8	Ankra-Badu1	organ weights	(none)	liver weight [mg] LIVER 21208	QTL population		both	10wks	N=502	2009

Attie2:137	Attie2	organ weights	high-fat high-sucrose diet	liver left lobe weight after diet [g] liver_wt_L 110754	DO population		both	19-26wks	N=194	2018

Attie2:138	Attie2	organ weights	high-fat high-sucrose diet	liver weight minus left lobe after diet [g] liver_wt_remain 110755	DO population		both	19-26wks	N=194	2018

Attie2:139	Attie2	organ weights	high-fat high-sucrose diet	liver weight total after diet [g] liver_wt_tot 110756	DO population		both	19-26wks	N=194	2018

Auwerx1:227	Auwerx1	organ weights	high-fat diet	liver weight [g] liver_wt 111406 CD HFD	BXD w/par	57	m	29wks	N=4	2016

Auwerx2:133	Auwerx2	organ weights	(none)	liver weight [g] liver_wt 114661 CD HFD	inbred w/CC8	9	both	21wks	N=4	2021

Bopp1:7	Bopp1	health assessment	Plasmodium berghei	percentage of parasites in liver relative to all organs tested [%] luciferase_liver 36407	inbred	28	both	8-12wks	N=2	2010

Brockmann1:9	Brockmann1	organ weights	(none)	weight of liver [mg] Liver 21309	QTL population		both	6wks	N=138	2009

Brockmann1:26	Brockmann1	organ weights	(none)	weight of liver [mg] liver 21506	QTL population		both	6wks	N=201	2009

Cheverud1:23	Cheverud1	organ weights	high-fat diet	liver weight as percentage of body weight [%] liverwt_adj 17823 control diet high-fat diet	LGXSM w/par	17	both	20-30wks	N=8	2004

GMC21:4	GMC21	organ weights	(none)	liver weight [g] liver_wt 57004	inbred w/CC8	8	both	21wks	N=11	2018

Harrill1:5	Harrill1	organ weights	isoniazid	liver weight [g] liver 39505 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:7	Harrill1	organ weights	isoniazid	liver weight as percentage of body weight [%] pct_liver 39507 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:26	Harrill1	lipid profile	isoniazid	hepatic cholesterol (CHOL) [mg/dL] liver_CHOL 39526 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:31	Harrill1	lipid profile	isoniazid	hepatic triglycerides (TG) [mg/dL] liver_TG 39531 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:41	Harrill1	histopathology	isoniazid	lymphohistiocytic, portal, multifocal infiltrate [score] lymphohistio_portal 39541 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:46	Harrill1	histopathology	isoniazid	hepatocytic cytoplasmic, microvesiculation, multifocal [score] microvesic_multi 39546 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:51	Harrill1	histopathology	isoniazid	hepatocytic cytoplasmic, microvesiculation, diffuse [score] microvesic_dif 39551 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:56	Harrill1	histopathology	isoniazid	hepatocytic hypertrophy, panlobular, diffuse [score] hypertro_pan 39556 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill2:61	Harrill2	organ weights	DB289	liver weight at sacrifice [g] LW 44161 control DB289	inbred	34	f	6-8wks	N=5	2012

Harrill2:65	Harrill2	organ weights	DB289	liver weight as percentage of body weight [%] pctLW_BW 44165 control DB289 difference	inbred	34	f	6-8wks	N=5	2012

Ishimori1:2	Ishimori1	organ weights	high-fat diet	liver weight [g] liver_wt 14002	QTL population		f	20wks	N=294	2004

Jaxpheno2:20	Jaxpheno2	organ weights	(none)	liver weight [g] liver 22720 age 8wks age 16wks	inbred	11	both		N=8	2006

Jaxpheno2:22	Jaxpheno2	organ weights	(none)	liver weight as percentage of body weight [%] pct_liver 22722 age 8wks age 16wks	inbred	11	both		N=8	2006

Klaassen1:2	Klaassen1	histopathology	cadmium	cadmium-induced toxicity to liver [designation] liver 16402 categorical	inbred	8	m	8wks		2001

Lyons1:1	Lyons1	organ weights	high-fat diet	liver weight [g] liver_wt 13001	QTL population		m	16-18wks	N=278	2003

Lyons2:1	Lyons2	organ weights	high-fat diet	liver weight [g] liver_wt 13101	QTL population		m	16-18wks	N=277	2003

Lyons2:2	Lyons2	organ weights	high-fat diet	liver-to-bw ratio [ratio] liver_bw_ratio 13102	QTL population		m	16-18wks	N=277	2003

Mrug1:1	Mrug1	histopathology	(none)	mean of biliary duct number [n] mean_BDN 17501	QTL population		both	10d	N=230	2005

Mrug1:2	Mrug1	histopathology	(none)	mean of log(biliary duct number) [log(n)] mean_logBDN 17502	QTL population		both	1wk	N=230	2005

Mrug1:3	Mrug1	histopathology	(none)	cholangitis severity (score 0-4, increasing severity) 0 = no/minimal inflammation, 4=severe and extensive cholangiohepatitis [score] Cholangitis 17503	QTL population		both	10d	N=230	2005

Nadeau2:11	Nadeau2	organ weights	high-fat high-sucrose diet	liver weight [g] liver_wt 53051	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:12	Nadeau2	lipid profile	high-fat high-sucrose diet	liver triglycerides (mg/g liver) liver_TG 53052	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:13	Nadeau2	lipid profile	high-fat high-sucrose diet	total liver triglycerides [g] liver_TG_tot 53053	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau3:15	Nadeau3	organ weights	high-fat high-sucrose diet	liver weight after 16 wks on diet [g] liver_wt 114358 chow HFHS	inbred	2	m	21wks	N=17	2016

Nadeau3:17	Nadeau3	lipid profile	high-fat high-sucrose diet	liver triglycerides per mg liver after 16 wks on diet [mg/g] liver_TG 114360 chow HFHS	inbred	2	m	21wks	N=17	2016

Nadeau3:19	Nadeau3	lipid profile	high-fat high-sucrose diet	total liver triglycerides after 16 wks on diet [mg] liver_TG_tot 114362 chow HFHS	inbred	2	m	21wks	N=17	2016

Paigen1:7	Paigen1	organ weights	high-fat diet	liver weight at sacrifice [g] liverweight 2907	inbred	43	both	15-19wks	N=9	2000

Paigen1:26	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (free per g liver) [mg] freeHCC 2926	inbred	43	both	15-19wks	N=6	2000

Paigen1:27	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (esterified per g liver) [mg] estHCC 2927	inbred	43	both	15-19wks	N=6	2000

Paigen1:28	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (total per g liver) [mg] totHCC 2928	inbred	43	both	15-19wks	N=8	2000

Paigen1:29	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (free to esterified ratio) [ratio] free_to_est 2929	inbred	43	both	15-19wks	N=6	2000

Paigen1:30	Paigen1	histopathology	high-fat diet	liver microvacuoles (score: 0-4) [score] microvacs 2930	inbred	43	both	15-19wks	N=3	2000

Paigen1:31	Paigen1	histopathology	high-fat diet	liver macrovacuoles (score: 0-4) [score] macrovacs 2931	inbred	43	both	15-19wks	N=3	2000

Paigen1:32	Paigen1	histopathology	high-fat diet	liver inflammation (score: 0-4) [score] inflammation 2932	inbred	43	both	15-19wks	N=3	2000

Paigen3:7	Paigen3	organ weights	high-fat diet	liver weight at sacrifice [g] liverweight 2807	obesity mutants	8	both	15-19wks	N=20	2000

Paigen3:26	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (free per g liver) [mg] freeHCC 2826	obesity mutants	8	both	15-19wks	N=6	2000

Paigen3:27	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (esterified per g liver) [mg] estHCC 2827	obesity mutants	8	both	15-19wks	N=6	2000

Paigen3:28	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (total per g liver) [mg] totHCC 2828	obesity mutants	8	both	15-19wks	N=9	2000

Paigen3:29	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (free to esterified ratio) [ratio] free_to_est 2829	obesity mutants	8	both	15-19wks	N=6	2000

Paigen3:30	Paigen3	histopathology	high-fat diet	liver microvacuoles (score: 0-4) [score] microvacs 2830	obesity mutants	7	both	15-19wks	N=3	2000

Paigen3:31	Paigen3	histopathology	high-fat diet	liver macrovacuoles (score: 0-4) [score] macrovacs 2831	obesity mutants	7	both	15-19wks	N=3	2000

Paigen3:32	Paigen3	histopathology	high-fat diet	liver inflammation (score: 0-4) [score] inflammation 2832	obesity mutants	7	both	15-19wks	N=3	2000

Reed2:51	Reed2	organ weights	(none)	liver weight [g] liver_wt 53151	B6.129 and 129.B6 consomic w/par	9	both	26wks	N=17	2015

Rodriguez1:1	Rodriguez1	in vitro assay	(none)	spleen and liver murine cytomegalovirus genome levels (normalized to endogenous b-actin) [ratio] CMV_LEVELS 24101	QTL population		both	8-12wks	N=92	2009

Rusyn5:11	Rusyn5	organ weights	high-fat diet and ethanol	liver weight as a percent of body weight [%] pctLW_BW 43011 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:13	Rusyn5	histopathology	high-fat diet and ethanol	liver steatosis (0-4) [score] steatosis 43013 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:15	Rusyn5	histopathology	high-fat diet and ethanol	liver inflammation (0-2) [score] inflammation 43015 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:17	Rusyn5	histopathology	high-fat diet and ethanol	liver necrosis (0-2) [score] necrosis 43017 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:19	Rusyn5	histopathology	high-fat diet and ethanol	total liver histopathology (0-8) [score] total_pathology 43019 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:21	Rusyn5	lipid profile	high-fat diet and ethanol	hepatic triglycerides (TG) [mg/g] liver_TG 43021 high-fat only high-fat and ethanol	inbred	6	m	8-14wks	N=3	2011

Rusyn5:23	Rusyn5	metabolite quantification	high-fat diet and ethanol	reduced liver glutathione (GSH) [nmol/mg] liver_GSH 43023 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:25	Rusyn5	metabolite quantification	high-fat diet and ethanol	oxidized liver glutathione (GSSG) [nmol/mg] liver_GSSG 43025 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:29	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of reduced to oxidized liver glutathione [ratio] liver_GSHratio 43029 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:31	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver homocysteine [nmol/mg] liver_homocysteine 43031 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:33	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:35	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver methionine [nmol/mg] liver_methionine 43035 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:37	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylmethionine (SAM) [nmol/mg] liver_SAM 43037 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:39	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of liver SAM to SAH (SAM/SAH) [ratio] liver_SAM_SAH 43039 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:42	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver BHMT, protein expression relative to high-fat-only group [%] liver_BHMT_hfe 43042	inbred	14	m	8-14wks	N=3	2011

Rusyn5:44	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver DDIT3 (formerly CHOP), protein expression relative to high-fat-only group [%] liver_DDIT3_hfe 43044	inbred	14	m	8-14wks	N=3	2011

Rusyn5:46	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver HSPA5 (formerly GRP78), protein expression relative to high-fat-only group [%] liver_HSPA5_hfe 43046	inbred	14	m	8-14wks	N=3	2011

Rusyn5:48	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group [%] liver_SREBF1_hfe 43048	inbred	14	m	8-14wks	N=3	2011

Rusyn5:50	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Acox1, mRNA abundance relative to high-fat-only group [%] liver_Acox1_hfe 43050	inbred	6	m	8-14wks	N=3	2011

Rusyn5:52	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Adipor2, mRNA abundance relative to high-fat-only group [%] liver_Adipor2_hfe 43052	inbred	6	m	8-14wks	N=3	2011

Rusyn5:54	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ahcy, mRNA abundance relative to high-fat-only group [%] liver_Ahcy_hfe 43054	inbred	14	m	8-14wks	N=3	2011

Rusyn5:56	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cbs, mRNA abundance relative to high-fat-only group [%] liver_Cbs_hfe 43056	inbred	14	m	8-14wks	N=3	2011

Rusyn5:58	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cebpa, mRNA abundance relative to high-fat-only group [%] liver_Cebpa_hfe 43058	inbred	14	m	8-14wks	N=3	2011

Rusyn5:60	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cth, mRNA abundance relative to high-fat-only group [%] liver_Cth_hfe 43060	inbred	14	m	8-14wks	N=3	2011

Rusyn5:62	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group [%] liver_Ddit3_hfe 43062	inbred	14	m	8-14wks	N=3	2011

Rusyn5:64	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Gnmt, mRNA abundance relative to high-fat-only group [%] liver_Gnmt_hfe 43064	inbred	14	m	8-14wks	N=3	2011

Rusyn5:66	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mat1a, mRNA abundance relative to high-fat-only group [%] liver_Mat1a_hfe 43066	inbred	14	m	8-14wks	N=3	2011

Rusyn5:68	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mthfr, mRNA abundance relative to high-fat-only group [%] liver_Mthfr_hfe 43068	inbred	14	m	8-14wks	N=3	2011

Rusyn5:70	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mtr, mRNA abundance relative to high-fat-only group [%] liver_Mtr_hfe 43070	inbred	14	m	8-14wks	N=3	2011

Rusyn5:72	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mttp, mRNA abundance relative to high-fat-only group [%] liver_Mttp_hfe 43072	inbred	6	m	8-14wks	N=3	2011

Rusyn5:74	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Srebf1, mRNA abundance relative to high-fat-only group [%] liver_Srebf1_hfe 43074	inbred	14	m	8-14wks	N=3	2011

Rusyn6:11	Rusyn6	organ weights	trichloroethylene	liver weight as a percent of body weight [%] liver_adj 51211 control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6:14	Rusyn6	histopathology	trichloroethylene	BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce 51214	inbred	7	m	6-7wks	N=3	2014

Rusyn6:16	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce 51216	inbred	7	m	6-7wks	N=4	2014

Rusyn6:18	Rusyn6	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce 51218	inbred	7	m	6-7wks	N=4	2014

Rusyn6:20	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce 51220	inbred	7	m	6-7wks	N=4	2014

Rusyn6:22	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce 51222	inbred	7	m	6-7wks	N=4	2014

Rusyn6:26	Rusyn6	RNA expression profiling	trichloroethylene	Acox1, mRNA in liver, relative to control group [ratio] Acox1_liver_tce 51226	inbred	7	m	6-7wks	N=3	2014

Rusyn6:28	Rusyn6	RNA expression profiling	trichloroethylene	Cyp4a10, mRNA in liver, relative to control group [ratio] Cyp4a10_liver_tce 51228	inbred	7	m	6-7wks	N=3	2014

Rusyn6:30	Rusyn6	RNA expression profiling	trichloroethylene	Ppara, mRNA in liver, relative to control group [ratio] Ppara_liver_tce 51230	inbred	7	m	6-7wks	N=3	2014

Schonfeld1:22	Schonfeld1	lipid profile	(none)	hepatic triglycerides (5h fast) [mg/g] hTG 32348	inbred	11	both	9-13wks	N=6	2005

Schonfeld1:25	Schonfeld1	organ weights	(none)	liver weight [g] LW 32361	inbred	11	both	9-13wks	N=6	2005

Schonfeld1:26	Schonfeld1	organ weights	(none)	liver weight as a percent of body weight [%] LW_BW 32362	inbred	11	both	9-13wks	N=6	2005

Schoonjans1:177	Schoonjans1	biomarker quantification	high-fat diet	bile acid 3-oxocholic acid amount in liver, at 29 wks [ng/mL] oxo_CA_liver 112808 CD	BXD w/par	2	m	29wks	N=1	2021

Schoonjans1:178	Schoonjans1	biomarker quantification	high-fat diet	bile acid 7-ketodeoxycholic acid amount in liver, at 29 wks [ng/mL] keto_DCA_liver 112809 CD HFD	BXD w/par	12	m	29wks	N=2	2021

Schoonjans1:180	Schoonjans1	biomarker quantification	high-fat diet	bile acid α-muricholic acid amount in liver, at 29 wks [ng/mL] aMCA_liver 112812 CD HFD	BXD w/par	36	m	29wks	N=3	2021

Schoonjans1:182	Schoonjans1	biomarker quantification	high-fat diet	bile acid β-muricholic acid amount in liver, at 29 wks [ng/mL] bMCA_liver 112814 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:184	Schoonjans1	biomarker quantification	high-fat diet	bile acid cholic acid amount in liver, at 29 wks [ng/mL] CA_liver 112816 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:186	Schoonjans1	biomarker quantification	high-fat diet	bile acid chenodeoxycholic acid amount in liver, at 29 wks [ng/mL] CDCA_liver 112818 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:188	Schoonjans1	biomarker quantification	high-fat diet	bile acid deoxycholic acid amount in liver, at 29 wks [ng/mL] DCA_liver 112820 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:190	Schoonjans1	biomarker quantification	high-fat diet	bile acid glycocholic acid amount in liver, at 29 wks [ng/mL] GCA_liver 112822 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:192	Schoonjans1	biomarker quantification	high-fat diet	bile acid glycochenodeoxycholic acid amount in liver, at 29 wks [ng/mL] GCDCA_liver 112824 CD HFD	BXD w/par	3	m	29wks	N=1	2021

Schoonjans1:194	Schoonjans1	biomarker quantification	high-fat diet	bile acid glycolithocholic acid amount in liver, at 29 wks [ng/mL] GLCA_liver 112827 CD HFD	BXD w/par	3	m	29wks	N=1	2021

Schoonjans1:196	Schoonjans1	biomarker quantification	high-fat diet	bile acid glycoursodeoxycholic acid amount in liver, at 29 wks [ng/mL] GUDCA_liver 112829 CD HFD	BXD w/par	34	m	29wks	N=3	2021

Schoonjans1:198	Schoonjans1	biomarker quantification	high-fat diet	bile acid isodeoxycholic acid amount in liver, at 29 wks [ng/mL] IsoDCA_liver 112831 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:200	Schoonjans1	biomarker quantification	high-fat diet	bile acid murocholic acid amount in liver, at 29 wks [ng/mL] MDCA_liver 112833 CD HFD	BXD w/par	10	m	29wks	N=1	2021

Schoonjans1:202	Schoonjans1	biomarker quantification	high-fat diet	bile acid tauro-α-muricholic acid amount in liver, at 29 wks [ng/mL] TaMCA_liver 112835 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:204	Schoonjans1	biomarker quantification	high-fat diet	bile acid tauro-β-muricholic acid amount in liver, at 29 wks [ng/mL] TbMCA_liver 112837 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:206	Schoonjans1	biomarker quantification	high-fat diet	bile acid taurocholic acid amount in liver, at 29 wks [ng/mL] TCA_liver 112839 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:208	Schoonjans1	biomarker quantification	high-fat diet	bile acid taurochenodeoxycholic acid amount in liver, at 29 wks [ng/mL] TCDCA_liver 112841 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:210	Schoonjans1	biomarker quantification	high-fat diet	bile acid taurodeoxycholic acid amount in liver, at 29 wks [ng/mL] TDCA_liver 112843 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:212	Schoonjans1	biomarker quantification	high-fat diet	bile acid taurohyodeoxycholic acid amount in liver, at 29 wks [ng/mL] THDCA_liver 112845 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:214	Schoonjans1	biomarker quantification	high-fat diet	bile acid taurolithocholic acid amount in liver, at 29 wks [ng/mL] TLCA_liver 112847 CD HFD	BXD w/par	23	m	29wks	N=3	2021

Schoonjans1:216	Schoonjans1	biomarker quantification	high-fat diet	bile acid tauroursodeoxycholic acid amount in liver, at 29 wks [ng/mL] TUDCA_liver 112849 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:218	Schoonjans1	biomarker quantification	high-fat diet	bile acid ω-muricholic acid amount in liver, at 29 wks [ng/mL] wMCA_liver 112853 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Schoonjans1:220	Schoonjans1	organ weights	high-fat diet	liver weight [g] liver_wt 112855 CD HFD	BXD w/par	36	m	29wks	N=5	2021

Sunde1:11	Sunde1	RNA expression profiling	selenium	liver Dio1, mRNA abundance relative to C57BL/6J +Se [%] Dio1_mRNA 65311 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:13	Sunde1	RNA expression profiling	selenium	liver Gpx1, mRNA abundance relative to C57BL/6J +Se [%] Gpx1_mRNA 65313 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:15	Sunde1	RNA expression profiling	selenium	liver Gpx3, mRNA abundance relative to C57BL/6J +Se [%] Gpx3_mRNA 65315 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:17	Sunde1	RNA expression profiling	selenium	liver Gpx4, mRNA abundance relative to C57BL/6J +Se [%] Gpx4_mRNA 65317 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:19	Sunde1	RNA expression profiling	selenium	liver Msrb1, mRNA abundance relative to C57BL/6J +Se [%] Msrb1_mRNA 65319 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:21	Sunde1	RNA expression profiling	selenium	liver Selenof, mRNA abundance relative to C57BL/6J +Se [%] Selenof_mRNA 65321 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:23	Sunde1	RNA expression profiling	selenium	liver Selenoh, mRNA abundance relative to C57BL/6J +Se [%] Selenoh_mRNA 65323 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:25	Sunde1	RNA expression profiling	selenium	liver Selenok, mRNA abundance relative to C57BL/6J +Se [%] Selenok_mRNA 65325 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:27	Sunde1	RNA expression profiling	selenium	liver Selenom, mRNA abundance relative to C57BL/6J +Se [%] Selenom_mRNA 65327 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:29	Sunde1	RNA expression profiling	selenium	liver Selenon, mRNA abundance relative to C57BL/6J +Se [%] Selenon_mRNA 65329 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:31	Sunde1	RNA expression profiling	selenium	liver Selenoo, mRNA abundance relative to C57BL/6J +Se [%] Selenoo_mRNA 65331 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:33	Sunde1	RNA expression profiling	selenium	liver Selenop, mRNA abundance relative to C57BL/6J +Se [%] Selenop_mRNA 65333 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:35	Sunde1	RNA expression profiling	selenium	liver Selenos, mRNA abundance relative to C57BL/6J +Se [%] Selenos_mRNA 65335 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:37	Sunde1	RNA expression profiling	selenium	liver Selenot, mRNA abundance relative to C57BL/6J +Se [%] Selenot_mRNA 65337 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:39	Sunde1	RNA expression profiling	selenium	liver Selenow, mRNA abundance relative to C57BL/6J +Se [%] Selenow_mRNA 65339 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:41	Sunde1	RNA expression profiling	selenium	liver Txnrd1, mRNA abundance relative to C57BL/6J +Se [%] Txnrd1_mRNA 65341 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:43	Sunde1	RNA expression profiling	selenium	liver Txnrd2, mRNA abundance relative to C57BL/6J +Se [%] Txnrd2_mRNA 65343 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:45	Sunde1	RNA expression profiling	selenium	liver Txnrd3, mRNA abundance relative to C57BL/6J +Se [%] Txnrd3_mRNA 65345 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:47	Sunde1	protein activity assessment	selenium	liver Gpx1 enzyme activity (EU/g protein) [EU/g] Gpx1_act_liv 65347 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:53	Sunde1	protein activity assessment	selenium	liver Gpx4 enzyme activity (EU/g protein) [EU/g] Gpx4_act 65353 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:55	Sunde1	protein activity assessment	selenium	liver Txnrd enzyme activity (EU/g protein) [EU/g] Txnrd_act 65355 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Threadgill1:1	Threadgill1	organ weights	acetaminophen	liver weight 24h after treatment [g] liverwt 19401 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=4	2005

Threadgill1:4	Threadgill1	histopathology	acetaminophen	necrosis [%] liver_necrosis 19404 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill1:14	Threadgill1	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/g] GSH 19414 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:16	Threadgill1	metabolite quantification	acetaminophen	oxidized glutathione (GSSG) [µmol/g] GSSG 19416 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:18	Threadgill1	metabolite quantification	acetaminophen	total glutathione (GSH plus GSSG) [µmol/g] GSH_total 19418 control post-Rx 300 mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:20	Threadgill1	metabolite quantification	acetaminophen	ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] GSHratio 19420 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:82	Threadgill1	metabolic panel	acetaminophen	catalase [µg/mL] catalase 19482 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:83	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 1A2 isoform [pmol/mg] CYP1A2 19483 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:84	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 2E1 isoform [pmol/mg] CYP2E1 19484 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:86	Threadgill1	metabolite quantification	acetaminophen	glutathione transferase [µg/mL] GSTpi 19486 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill2:3	Threadgill2	histopathology	acetaminophen	liver necrosis score [%] liver_necrosis 39603	inbred	5	m	6-8wks	N=5	2005

Threadgill2:4	Threadgill2	histopathology	acetaminophen	percent nitrotyrosine staining (marker of hepatocyte injury) [%] pct_nitrotyrosine 39604	inbred	5	m	6-8wks	N=5	2005

Threadgill2:5	Threadgill2	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/mg] GSH 39605 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:6	Threadgill2	metabolite quantification	acetaminophen	percent reduced glutathione [%] GSH_pct 39606 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:7	Threadgill2	metabolite quantification	acetaminophen	total glutathione [µmol/mg] GSH_total 39607 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Vulpe1:1	Vulpe1	mineral quantification	(none)	copper (Cu) content in liver, dry weight [µg/g] copper 36801	inbred	18	both	8wks	N=6	2010

Vulpe1:2	Vulpe1	mineral quantification	(none)	iron (Fe) content in liver, dry weight [µg/g] iron 36802	inbred	18	both	8wks	N=6	2010

Vulpe1:3	Vulpe1	mineral quantification	(none)	zinc (Zn) content in liver, dry weight [µg/g] zinc 36803	inbred	18	both	8wks	N=6	2010

Wittenburg1:2	Wittenburg1	organ weights	high-fat diet	liver weight [g] liver_wt 12602	QTL population		both	18-20wks	N=130	2002

Wittenburg1:3	Wittenburg1	organ weights	high-fat diet	liver-to-bw ratio [ratio] liver_bw_ratio 12603	QTL population		both	18-20wks	N=130	2002

Wittenburg2:3	Wittenburg2	organ weights	high-fat diet	liver weight [g] liver_wt 13803	QTL population		both	14-16wks	N=152	2003

Wittenburg2:4	Wittenburg2	organ weights	high-fat diet	percentage of total body weight that is liver weight [%] liver_wt_pct 13804	QTL population		both	14-16wks	N=152	2003

Wittenburg3:2	Wittenburg3	organ weights	high-fat diet	liver weight [g] liver_wt 18202	QTL population		both	14-16wks	N=162	2005

Wittenburg3:3	Wittenburg3	organ weights	high-fat diet	percentage of body weight that is liver [%] pct_liver_wt 18203	QTL population		both	14-16wks	N=162	2005

Xenakis2:246	Xenakis2	metabolite quantification	arsenic	inorganic arsenic (iAs) in liver (ppb), 24 wks after iAs [n] iAs_liver 118400	DO population		m	34wks	N=73	2022

Xenakis2:247	Xenakis2	metabolite quantification	arsenic	monomethyl-arsenic acid (MMA) in liver (ppb), 24 wks after iAs [n] MMA_liver 118401	DO population		m	34wks	N=73	2022

Xenakis2:248	Xenakis2	metabolite quantification	arsenic	dimethyl-arsenic acid (DMA) in liver (ppb), 24 wks after iAs [n] DMA_liver 118402	DO population		m	34wks	N=73	2022

Xenakis2:249	Xenakis2	metabolite quantification	arsenic	percentage of of inorganic arsenic (iAs) in liver, 24 wks after iAs [%] iAs_liver_pct 118403	DO population		m	34wks	N=73	2022

Xenakis2:250	Xenakis2	metabolite quantification	arsenic	percentage of monomethyl-arsenic acid (MMA) in liver, 24 wks after iAs [%] MMA_liver_pct 118404	DO population		m	34wks	N=73	2022

Xenakis2:251	Xenakis2	metabolite quantification	arsenic	percentage of dimethyl-arsenic acid (DMA) in liver, 24 wks after iAs [%] DMA_liver_pct 118405	DO population		m	34wks	N=73	2022

Yi1:6	Yi1	organ weights	(none)	liver weight at week 12 [mg] liver12wk 20606	QTL population		both	12wks	N=210	2007

Ankra-Badu1

organ weights

(none)

liver weight [mg] LIVER 21208

QTL population

both

10wks

N=502

2009

Attie2

organ weights

high-fat high-sucrose diet

liver left lobe weight after diet [g] liver_wt_L 110754

DO population

both

19-26wks

N=194

2018

Attie2

organ weights

high-fat high-sucrose diet

liver weight minus left lobe after diet [g] liver_wt_remain 110755

DO population

both

19-26wks

N=194

2018

Attie2

organ weights

high-fat high-sucrose diet

liver weight total after diet [g] liver_wt_tot 110756

DO population

both

19-26wks

N=194

2018

Auwerx1

organ weights

high-fat diet

liver weight [g] liver_wt 111406 CD HFD

BXD w/par

57

m

29wks

N=4

2016

Auwerx2

organ weights

(none)

liver weight [g] liver_wt 114661 CD HFD

inbred w/CC8

9

both

21wks

N=4

2021

Bopp1

health assessment

Plasmodium berghei

percentage of parasites in liver relative to all organs tested [%] luciferase_liver 36407

inbred

28

both

8-12wks

N=2

2010

Brockmann1

organ weights

(none)

weight of liver [mg] Liver 21309

QTL population

both

6wks

N=138

2009

Brockmann1

organ weights

(none)

weight of liver [mg] liver 21506

QTL population

both

6wks

N=201

2009

Cheverud1

organ weights

high-fat diet

liver weight as percentage of body weight [%] liverwt_adj 17823 control diet high-fat diet

LGXSM w/par

17

both

20-30wks

N=8

2004

GMC21

organ weights

(none)

liver weight [g] liver_wt 57004

inbred w/CC8

8

both

21wks

N=11

2018

Harrill1

organ weights

isoniazid

liver weight [g] liver 39505 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

organ weights

isoniazid

liver weight as percentage of body weight [%] pct_liver 39507 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

lipid profile

isoniazid

hepatic cholesterol (CHOL) [mg/dL] liver_CHOL 39526 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

lipid profile

isoniazid

hepatic triglycerides (TG) [mg/dL] liver_TG 39531 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

histopathology

isoniazid

lymphohistiocytic, portal, multifocal infiltrate [score] lymphohistio_portal 39541 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

histopathology

isoniazid

hepatocytic cytoplasmic, microvesiculation, multifocal [score] microvesic_multi 39546 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

histopathology

isoniazid

hepatocytic cytoplasmic, microvesiculation, diffuse [score] microvesic_dif 39551 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill1

histopathology

isoniazid

hepatocytic hypertrophy, panlobular, diffuse [score] hypertro_pan 39556 control isoniazid

inbred

34

f

8-10wks

N=4

2011

Harrill2

organ weights

DB289

liver weight at sacrifice [g] LW 44161 control DB289

inbred

34

f

6-8wks

N=5

2012

Harrill2

organ weights

DB289

liver weight as percentage of body weight [%] pctLW_BW 44165 control DB289 difference

inbred

34

f

6-8wks

N=5

2012

Ishimori1

organ weights

high-fat diet

liver weight [g] liver_wt 14002

QTL population

f

20wks

N=294

2004

Jaxpheno2

organ weights

(none)

liver weight [g] liver 22720 age 8wks age 16wks

inbred

11

both

N=8

2006

Jaxpheno2

organ weights

(none)

liver weight as percentage of body weight [%] pct_liver 22722 age 8wks age 16wks

inbred

11

both

N=8

2006

Klaassen1

histopathology

cadmium

cadmium-induced toxicity to liver [designation] liver 16402 categorical

inbred

8

m

8wks

2001

Lyons1

organ weights

high-fat diet

liver weight [g] liver_wt 13001

QTL population

m

16-18wks

N=278

2003

Lyons2

organ weights

high-fat diet

liver weight [g] liver_wt 13101

QTL population

m

16-18wks

N=277

2003

Lyons2

organ weights

high-fat diet

liver-to-bw ratio [ratio] liver_bw_ratio 13102

QTL population

m

16-18wks

N=277

2003

Mrug1

histopathology

(none)

mean of biliary duct number [n] mean_BDN 17501

QTL population

both

10d

N=230

2005

Mrug1

histopathology

(none)

mean of log(biliary duct number) [log(n)] mean_logBDN 17502

QTL population

both

1wk

N=230

2005

Mrug1

histopathology

(none)

cholangitis severity (score 0-4, increasing severity) 0 = no/minimal inflammation, 4=severe and extensive cholangiohepatitis [score] Cholangitis 17503

QTL population

both

10d

N=230

2005

Nadeau2

organ weights

high-fat high-sucrose diet

liver weight [g] liver_wt 53051

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

lipid profile

high-fat high-sucrose diet

liver triglycerides (mg/g liver) liver_TG 53052

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

lipid profile

high-fat high-sucrose diet

total liver triglycerides [g] liver_TG_tot 53053

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau3

organ weights

high-fat high-sucrose diet

liver weight after 16 wks on diet [g] liver_wt 114358 chow HFHS

inbred

2

m

21wks

N=17

2016

Nadeau3

lipid profile

high-fat high-sucrose diet

liver triglycerides per mg liver after 16 wks on diet [mg/g] liver_TG 114360 chow HFHS

inbred

2

m

21wks

N=17

2016

Nadeau3

lipid profile

high-fat high-sucrose diet

total liver triglycerides after 16 wks on diet [mg] liver_TG_tot 114362 chow HFHS

inbred

2

m

21wks

N=17

2016

Paigen1

organ weights

high-fat diet

liver weight at sacrifice [g] liverweight 2907

inbred

43

both

15-19wks

N=9

2000

Paigen1

lipid profile

high-fat diet

hepatic cholesterol concentration (free per g liver) [mg] freeHCC 2926

inbred

43

both

15-19wks

N=6

2000

Paigen1

lipid profile

high-fat diet

hepatic cholesterol concentration (esterified per g liver) [mg] estHCC 2927

inbred

43

both

15-19wks

N=6

2000

Paigen1

lipid profile

high-fat diet

hepatic cholesterol concentration (total per g liver) [mg] totHCC 2928

inbred

43

both

15-19wks

N=8

2000

Paigen1

lipid profile

high-fat diet

hepatic cholesterol concentration (free to esterified ratio) [ratio] free_to_est 2929

inbred

43

both

15-19wks

N=6

2000

Paigen1

histopathology

high-fat diet

liver microvacuoles (score: 0-4) [score] microvacs 2930

inbred

43

both

15-19wks

N=3

2000

Paigen1

histopathology

high-fat diet

liver macrovacuoles (score: 0-4) [score] macrovacs 2931

inbred

43

both

15-19wks

N=3

2000

Paigen1

histopathology

high-fat diet

liver inflammation (score: 0-4) [score] inflammation 2932

inbred

43

both

15-19wks

N=3

2000

Paigen3

organ weights

high-fat diet

liver weight at sacrifice [g] liverweight 2807

obesity mutants

8

both

15-19wks

N=20

2000

Paigen3

lipid profile

high-fat diet

hepatic cholesterol concentration (free per g liver) [mg] freeHCC 2826

obesity mutants

8

both

15-19wks

N=6

2000

Paigen3

lipid profile

high-fat diet

hepatic cholesterol concentration (esterified per g liver) [mg] estHCC 2827

obesity mutants

8

both

15-19wks

N=6

2000

Paigen3

lipid profile

high-fat diet

hepatic cholesterol concentration (total per g liver) [mg] totHCC 2828

obesity mutants

8

both

15-19wks

N=9

2000

Paigen3

lipid profile

high-fat diet

hepatic cholesterol concentration (free to esterified ratio) [ratio] free_to_est 2829

obesity mutants

8

both

15-19wks

N=6

2000

Paigen3

histopathology

high-fat diet

liver microvacuoles (score: 0-4) [score] microvacs 2830

obesity mutants

7

both

15-19wks

N=3

2000

Paigen3

histopathology

high-fat diet

liver macrovacuoles (score: 0-4) [score] macrovacs 2831

obesity mutants

7

both

15-19wks

N=3

2000

Paigen3

histopathology

high-fat diet

liver inflammation (score: 0-4) [score] inflammation 2832

obesity mutants

7

both

15-19wks

N=3

2000

Reed2

organ weights

(none)

liver weight [g] liver_wt 53151

B6.129 and 129.B6 consomic w/par

9

both

26wks

N=17

2015

Rodriguez1

in vitro assay

(none)

spleen and liver murine cytomegalovirus genome levels (normalized to endogenous b-actin) [ratio] CMV_LEVELS 24101

QTL population

both

8-12wks

N=92

2009

Rusyn5

organ weights

high-fat diet and ethanol

liver weight as a percent of body weight [%] pctLW_BW 43011 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver steatosis (0-4) [score] steatosis 43013 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver inflammation (0-2) [score] inflammation 43015 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver necrosis (0-2) [score] necrosis 43017 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

total liver histopathology (0-8) [score] total_pathology 43019 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

lipid profile

high-fat diet and ethanol

hepatic triglycerides (TG) [mg/g] liver_TG 43021 high-fat only high-fat and ethanol

inbred

6

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

reduced liver glutathione (GSH) [nmol/mg] liver_GSH 43023 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

oxidized liver glutathione (GSSG) [nmol/mg] liver_GSSG 43025 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

ratio of reduced to oxidized liver glutathione [ratio] liver_GSHratio 43029 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver homocysteine [nmol/mg] liver_homocysteine 43031 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver methionine [nmol/mg] liver_methionine 43035 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver S-adenosylmethionine (SAM) [nmol/mg] liver_SAM 43037 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

ratio of liver SAM to SAH (SAM/SAH) [ratio] liver_SAM_SAH 43039 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver BHMT, protein expression relative to high-fat-only group [%] liver_BHMT_hfe 43042

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver DDIT3 (formerly CHOP), protein expression relative to high-fat-only group [%] liver_DDIT3_hfe 43044

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver HSPA5 (formerly GRP78), protein expression relative to high-fat-only group [%] liver_HSPA5_hfe 43046

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group [%] liver_SREBF1_hfe 43048

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Acox1, mRNA abundance relative to high-fat-only group [%] liver_Acox1_hfe 43050

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Adipor2, mRNA abundance relative to high-fat-only group [%] liver_Adipor2_hfe 43052

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Ahcy, mRNA abundance relative to high-fat-only group [%] liver_Ahcy_hfe 43054

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cbs, mRNA abundance relative to high-fat-only group [%] liver_Cbs_hfe 43056

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cebpa, mRNA abundance relative to high-fat-only group [%] liver_Cebpa_hfe 43058

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cth, mRNA abundance relative to high-fat-only group [%] liver_Cth_hfe 43060

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group [%] liver_Ddit3_hfe 43062

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Gnmt, mRNA abundance relative to high-fat-only group [%] liver_Gnmt_hfe 43064

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mat1a, mRNA abundance relative to high-fat-only group [%] liver_Mat1a_hfe 43066

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mthfr, mRNA abundance relative to high-fat-only group [%] liver_Mthfr_hfe 43068

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mtr, mRNA abundance relative to high-fat-only group [%] liver_Mtr_hfe 43070

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mttp, mRNA abundance relative to high-fat-only group [%] liver_Mttp_hfe 43072

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Srebf1, mRNA abundance relative to high-fat-only group [%] liver_Srebf1_hfe 43074

inbred

14

m

8-14wks

N=3

2011

Rusyn6

organ weights

trichloroethylene

liver weight as a percent of body weight [%] liver_adj 51211 control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

histopathology

trichloroethylene

BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce 51214

inbred

7

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce 51216

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce 51218

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce 51220

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce 51222

inbred

7

m

6-7wks

N=4

2014

Rusyn6

RNA expression profiling

trichloroethylene

Acox1, mRNA in liver, relative to control group [ratio] Acox1_liver_tce 51226

inbred

7

m

6-7wks

N=3

2014

Rusyn6

RNA expression profiling

trichloroethylene

Cyp4a10, mRNA in liver, relative to control group [ratio] Cyp4a10_liver_tce 51228

inbred

7

m

6-7wks

N=3

2014

Rusyn6

RNA expression profiling

trichloroethylene

Ppara, mRNA in liver, relative to control group [ratio] Ppara_liver_tce 51230

inbred

7

m

6-7wks

N=3

2014

Schonfeld1

lipid profile

(none)

hepatic triglycerides (5h fast) [mg/g] hTG 32348

inbred

11

both

9-13wks

N=6

2005

Schonfeld1

organ weights

(none)

liver weight [g] LW 32361

inbred

11

both

9-13wks

N=6

2005

Schonfeld1

organ weights

(none)

liver weight as a percent of body weight [%] LW_BW 32362

inbred

11

both

9-13wks

N=6

2005

Schoonjans1

biomarker quantification

high-fat diet

bile acid 3-oxocholic acid amount in liver, at 29 wks [ng/mL] oxo_CA_liver 112808 CD

BXD w/par

2

m

29wks

N=1

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid 7-ketodeoxycholic acid amount in liver, at 29 wks [ng/mL] keto_DCA_liver 112809 CD HFD

BXD w/par

12

m

29wks

N=2

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid α-muricholic acid amount in liver, at 29 wks [ng/mL] aMCA_liver 112812 CD HFD

BXD w/par

36

m

29wks

N=3

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid β-muricholic acid amount in liver, at 29 wks [ng/mL] bMCA_liver 112814 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid cholic acid amount in liver, at 29 wks [ng/mL] CA_liver 112816 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid chenodeoxycholic acid amount in liver, at 29 wks [ng/mL] CDCA_liver 112818 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid deoxycholic acid amount in liver, at 29 wks [ng/mL] DCA_liver 112820 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid glycocholic acid amount in liver, at 29 wks [ng/mL] GCA_liver 112822 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid glycochenodeoxycholic acid amount in liver, at 29 wks [ng/mL] GCDCA_liver 112824 CD HFD

BXD w/par

3

m

29wks

N=1

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid glycolithocholic acid amount in liver, at 29 wks [ng/mL] GLCA_liver 112827 CD HFD

BXD w/par

3

m

29wks

N=1

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid glycoursodeoxycholic acid amount in liver, at 29 wks [ng/mL] GUDCA_liver 112829 CD HFD

BXD w/par

34

m

29wks

N=3

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid isodeoxycholic acid amount in liver, at 29 wks [ng/mL] IsoDCA_liver 112831 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid murocholic acid amount in liver, at 29 wks [ng/mL] MDCA_liver 112833 CD HFD

BXD w/par

10

m

29wks

N=1

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid tauro-α-muricholic acid amount in liver, at 29 wks [ng/mL] TaMCA_liver 112835 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid tauro-β-muricholic acid amount in liver, at 29 wks [ng/mL] TbMCA_liver 112837 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid taurocholic acid amount in liver, at 29 wks [ng/mL] TCA_liver 112839 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid taurochenodeoxycholic acid amount in liver, at 29 wks [ng/mL] TCDCA_liver 112841 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid taurodeoxycholic acid amount in liver, at 29 wks [ng/mL] TDCA_liver 112843 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid taurohyodeoxycholic acid amount in liver, at 29 wks [ng/mL] THDCA_liver 112845 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid taurolithocholic acid amount in liver, at 29 wks [ng/mL] TLCA_liver 112847 CD HFD

BXD w/par

23

m

29wks

N=3

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid tauroursodeoxycholic acid amount in liver, at 29 wks [ng/mL] TUDCA_liver 112849 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

biomarker quantification

high-fat diet

bile acid ω-muricholic acid amount in liver, at 29 wks [ng/mL] wMCA_liver 112853 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Schoonjans1

organ weights

high-fat diet

liver weight [g] liver_wt 112855 CD HFD

BXD w/par

36

m

29wks

N=5

2021

Sunde1

RNA expression profiling

selenium

liver Dio1, mRNA abundance relative to C57BL/6J +Se [%] Dio1_mRNA 65311 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Gpx1, mRNA abundance relative to C57BL/6J +Se [%] Gpx1_mRNA 65313 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Gpx3, mRNA abundance relative to C57BL/6J +Se [%] Gpx3_mRNA 65315 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Gpx4, mRNA abundance relative to C57BL/6J +Se [%] Gpx4_mRNA 65317 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Msrb1, mRNA abundance relative to C57BL/6J +Se [%] Msrb1_mRNA 65319 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenof, mRNA abundance relative to C57BL/6J +Se [%] Selenof_mRNA 65321 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenoh, mRNA abundance relative to C57BL/6J +Se [%] Selenoh_mRNA 65323 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenok, mRNA abundance relative to C57BL/6J +Se [%] Selenok_mRNA 65325 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenom, mRNA abundance relative to C57BL/6J +Se [%] Selenom_mRNA 65327 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenon, mRNA abundance relative to C57BL/6J +Se [%] Selenon_mRNA 65329 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenoo, mRNA abundance relative to C57BL/6J +Se [%] Selenoo_mRNA 65331 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenop, mRNA abundance relative to C57BL/6J +Se [%] Selenop_mRNA 65333 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenos, mRNA abundance relative to C57BL/6J +Se [%] Selenos_mRNA 65335 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenot, mRNA abundance relative to C57BL/6J +Se [%] Selenot_mRNA 65337 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Selenow, mRNA abundance relative to C57BL/6J +Se [%] Selenow_mRNA 65339 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Txnrd1, mRNA abundance relative to C57BL/6J +Se [%] Txnrd1_mRNA 65341 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Txnrd2, mRNA abundance relative to C57BL/6J +Se [%] Txnrd2_mRNA 65343 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

RNA expression profiling

selenium

liver Txnrd3, mRNA abundance relative to C57BL/6J +Se [%] Txnrd3_mRNA 65345 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

protein activity assessment

selenium

liver Gpx1 enzyme activity (EU/g protein) [EU/g] Gpx1_act_liv 65347 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

protein activity assessment

selenium

liver Gpx4 enzyme activity (EU/g protein) [EU/g] Gpx4_act 65353 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Sunde1

protein activity assessment

selenium

liver Txnrd enzyme activity (EU/g protein) [EU/g] Txnrd_act 65355 Se deficient Se sufficient

inbred w/CC8

8

m

11-14wks

N=1

2018

Threadgill1

organ weights

acetaminophen

liver weight 24h after treatment [g] liverwt 19401 dose (mg/kg): control 100 200 300

inbred w/CC7

37

m

8-17wks

N=4

2005

Threadgill1

histopathology

acetaminophen

necrosis [%] liver_necrosis 19404 dose (mg/kg): control 100 200 300

inbred w/CC7

37

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

reduced glutathione (GSH) [µmol/g] GSH 19414 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

oxidized glutathione (GSSG) [µmol/g] GSSG 19416 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

total glutathione (GSH plus GSSG) [µmol/g] GSH_total 19418 control post-Rx 300 mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] GSHratio 19420 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolic panel

acetaminophen

catalase [µg/mL] catalase 19482 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

biomarker quantification

acetaminophen

cytochrome P450 1A2 isoform [pmol/mg] CYP1A2 19483 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

biomarker quantification

acetaminophen

cytochrome P450 2E1 isoform [pmol/mg] CYP2E1 19484 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

glutathione transferase [µg/mL] GSTpi 19486 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill2

histopathology

acetaminophen

liver necrosis score [%] liver_necrosis 39603

inbred

5

m

6-8wks

N=5

2005

Threadgill2

histopathology

acetaminophen

percent nitrotyrosine staining (marker of hepatocyte injury) [%] pct_nitrotyrosine 39604

inbred

5

m

6-8wks

N=5

2005

Threadgill2

metabolite quantification

acetaminophen

reduced glutathione (GSH) [µmol/mg] GSH 39605 control post-Rx 300 mg/kg

inbred

5

m

6-8wks

N=4

2005

Threadgill2

metabolite quantification

acetaminophen

percent reduced glutathione [%] GSH_pct 39606 control post-Rx 300 mg/kg

inbred

5

m

6-8wks

N=4

2005

Threadgill2

metabolite quantification

acetaminophen

total glutathione [µmol/mg] GSH_total 39607 control post-Rx 300 mg/kg

inbred

5

m

6-8wks

N=4

2005

Vulpe1

mineral quantification

(none)

copper (Cu) content in liver, dry weight [µg/g] copper 36801

inbred

18

both

8wks

N=6

2010

Vulpe1

mineral quantification

(none)

iron (Fe) content in liver, dry weight [µg/g] iron 36802

inbred

18

both

8wks

N=6

2010

Vulpe1

mineral quantification

(none)

zinc (Zn) content in liver, dry weight [µg/g] zinc 36803

inbred

18

both

8wks

N=6

2010

Wittenburg1

organ weights

high-fat diet

liver weight [g] liver_wt 12602

QTL population

both

18-20wks

N=130

2002

Wittenburg1

organ weights

high-fat diet

liver-to-bw ratio [ratio] liver_bw_ratio 12603

QTL population

both

18-20wks

N=130

2002

Wittenburg2

organ weights

high-fat diet

liver weight [g] liver_wt 13803

QTL population

both

14-16wks

N=152

2003

Wittenburg2

organ weights

high-fat diet

percentage of total body weight that is liver weight [%] liver_wt_pct 13804

QTL population

both

14-16wks

N=152

2003

Wittenburg3

organ weights

high-fat diet

liver weight [g] liver_wt 18202

QTL population

both

14-16wks

N=162

2005

Wittenburg3

organ weights

high-fat diet

percentage of body weight that is liver [%] pct_liver_wt 18203

QTL population

both

14-16wks

N=162

2005

Xenakis2

metabolite quantification

arsenic

inorganic arsenic (iAs) in liver (ppb), 24 wks after iAs [n] iAs_liver 118400

DO population

m

34wks

N=73

2022

Xenakis2

metabolite quantification

arsenic

monomethyl-arsenic acid (MMA) in liver (ppb), 24 wks after iAs [n] MMA_liver 118401

DO population

m

34wks

N=73

2022

Xenakis2

metabolite quantification

arsenic

dimethyl-arsenic acid (DMA) in liver (ppb), 24 wks after iAs [n] DMA_liver 118402

DO population

m

34wks

N=73

2022

Xenakis2

metabolite quantification

arsenic

percentage of of inorganic arsenic (iAs) in liver, 24 wks after iAs [%] iAs_liver_pct 118403

DO population

m

34wks

N=73

2022

Xenakis2

metabolite quantification

arsenic

percentage of monomethyl-arsenic acid (MMA) in liver, 24 wks after iAs [%] MMA_liver_pct 118404

DO population

m

34wks

N=73

2022

Xenakis2

metabolite quantification

arsenic

percentage of dimethyl-arsenic acid (DMA) in liver, 24 wks after iAs [%] DMA_liver_pct 118405

DO population

m

34wks

N=73

2022

Yi1

organ weights

(none)

liver weight at week 12 [mg] liver12wk 20606

QTL population

both

12wks

N=210

2007

Filter Table Results