Harrill1: Drug study: Clinico-pathological survey of the liver and adverse reactions in response to isoniazid treatment in females of 34 inbred strains of mice (2011)

Church RJ, Wu H, Mosedale M, Sumner SJ, Pathmasiri W, Kurtz CL, Pletcher MT, Eaddy JS, Pandher K, Singer M, Batheja A, Watkins PB(7), Adkins K, Harrill AH(8). A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis. Toxicol Sci. 2014 Aug 1;140(2):481-92. doi: 10.1093/toxsci/kfu094. Epub 2014 May 20.   PubMed 24848797     FullText

Harrill1 downloads
• Download Harrill1 project data set     animal data, as uploaded
• Download Harrill1 animal data matrix     with factor-related expansion applied as necessary
• Download Harrill1 strain means, SD, N, etc.     one row per strain/sex/measure
• Harrill1 supplementary data
Investigators Alison Harrill       University of Arkansas for Medical Sciences,  Little Rock, AR
ContactAlison Harrill     AHHarrill@uams.edu     Lab web site
AcknowledgementsFunding provided by Pfizer, Inc., AstraZeneca, and Lilly; International Life Sciences Institute Health and Environmental Sciences Institute (ILSI HESI)
Project type Phenotype strain survey data set
MPD identifiersHarrill1     MPD:395
Data changelog No updates/corrections.       Initial release date: 06/2014.
Formatted citation
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A treatment/control study of isoniazid. Treated group received Rx daily for 3 days. Control group received vehicle only for 3 days. See protocol timeline for details. All measurements taken on day 4 unless otherwise stated.

Procedures conducted:
• body weight  Body weight. Isoniazid-treated vs. control.
• organ weights  Body, liver, kidney weights. Isoniazid-treated vs. control.
• metabolic panel  Alanine transaminase. Isoniazid-treated vs. control.
• lipid profile  Cholesterol, triglycerides. Hepatic lipids. Isoniazid-treated vs. control.
• histopathology  Liver pathology scores. Isoniazid-treated vs. control.

Mice: inbred   34 strains   ♀   age 8-10wks   2 experimental groups