Nadeau3: Diet-induced metabolic syndrome measures in males of C57BL/6J and A/J inbred strains of mice (2016)

Sinasac DS, Riordan JD, Spiezio SH, Yandell BS, Croniger CM, Nadeau JH. Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome. Int J Obes (Lond). 2016 Feb;40(2):346-55. doi: 10.1038/ijo.2015.184. Epub 2015 Sep 18.   PubMed 26381349  

Nadeau3 downloads
• Download Nadeau3 project data set     animal data, as uploaded
• Download Nadeau3 animal data matrix     with factor-related expansion applied as necessary
• Download Nadeau3 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Joseph H Nadeau       Maine Medical Center Research Institute,  Scarborough, ME
Participants Sinasac DS, Riordan JD, Spiezio SH, Yandell BS, Croniger CM
ContactJoseph H Nadeau     Lab web site
AcknowledgementsThe authors would like to thank Mary Slaughter and Sudha Iyengar for their helpful discussions.
Funding Provided ByNIH grants RR12305; AA017837; and Postdoctoral Fellowship Award from the Canadian Diabetics Association.
Project type Phenotype strain survey data set
MPD identifiersNadeau3     MPD:1095
Data changelog No updates/corrections.       Initial release date: 01/2023.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Ten measures of metabolic health such as body weight, BMI, blood glucose and insulin, plasma cholesterol, HOMA-IR, triglycerides, liver weight and triglycerides were assessed in susceptible C57BL/6J and resistant A/J male mice, fed either a control (chow) or a high-fat, high-sucrose (HFHS) diet.

Experimental groups in this study:
• Chow diet     • HFHS diet    

Procedures conducted:
• body weight  After 16 wks on high-fat high-sucrose diet.
• body size and weight  Body weight and body mass index after 16 wks of high-fat high-sucrose diet.
• hormone quantification  Insulin and insulin resistance after 16 wks of high-fat high-sucrose diet. Overnight fast.
• lipid profile  Cholesterol and triglycerides. Overnight fast, plasma. Hepatic triglycerides.
• organ weights  Liver weight after 16 wks of high-fat high-sucrose diet. Overnight fast.

Mice: inbred   2 strains   ♂   age 21 wks   2 experimental groups