Attie2: Diet effects on Type 2 diabetes associated physiological traits in a Diversity Outbred (DO) mouse population on a high-fat high-sucrose diet (2018)
Keller MP, Gatti DM, Schueler KL, Rabaglia ME, Stapleton DS, Simecek P, Vincent M, Allen S, Broman AT, Bacher R, Kendziorski C, Broman KW, Yandell BS, Churchill GA, Attie AD. Genetic Drivers of Pancreatic Islet Function.
Genetics. 2018 May;209(1):335-356. doi: 10.1534/genetics.118.300864. Epub 2018 Mar 22.
PubMed 29567659FullText
Mark P Keller University of Wisconsin, Madison, WI Gary A Churchill The Jackson Laboratory, Bar Harbor, ME Alan D Attie University of Wisconsin, Madison, WI
Participants
Gatti DM, Schueler KL, Rabaglia ME, Stapleton DS, Simecek P, Vincent M, Allen S, Broman AT, Bacher R, Kendziorski C, Broman KW, Yandell BS
NIH DK101573, DK102948, GM102756, AI117924, GM076483; Clinical and Translational Science Award program, through the NIH National Center for Advancing Translational Sciences (grant UL1 TR-000427)
Project type
Phenotype strain survey data set
MPD identifiers
Attie2 MPD:1020
Data changelog
No updates/corrections.
Initial release date: 10/2020.
Formatted citation
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Diversity Outbred mice were metabolically challenged with a high-fat (45% kcal), high-sucrose (34%) diet from 4 wks of age. DO mice were assessed for physiological traits related to Type 2 Diabetes at various time points.
Pancreatic islet gene expression data and genotypes are available at DODB (search for Attie).
Experimental groups in this study: • High-fat high-sucrose diet
Procedures conducted:
• colony observation
Number of days on high-fat high-sucrose diet.
• body weight
Weekly.
• intake monitoring
Food intake. Weekly.
• metabolic panel
Glucose, HOMA-IR, HOMA-B.
• hormone quantification
Plasma insulin, adiponectin, leptin. Ex vivo insulin secretion.