Phenotype measure:   Paigen3   estHCC

ID, description, units MPD:2827   estHCC   hepatic cholesterol concentration (esterified per g liver)   [mg]
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure lipid profile
Ontology mappings

  STRAIN COMPARISON PLOT
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Paigen3 - hepatic cholesterol concentration (esterified per g liver)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means36.7   mg 31.4   mg
Median of the strain means34.5   mg 27.4   mg
SD of the strain means± 6.99 ± 9.54
Coefficient of variation (CV)0.191 0.303
Min–max range of strain means28.3   –   47.7   mg 19.4   –   48.1   mg
Mean sample size per strain5.9   mice 6.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1116.151 1116.151 13.9924 0.0004
strain 6 2802.9468 467.1578 5.8564 0.0001
sex:strain 6 616.4127 102.7354 1.2879 0.2743
Residuals 69 5504.0362 79.7686


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 28.3 5.88   5 2.63 0.208 19.7, 34.4 -1.2
B6(AU)-Tubtub/J m 19.4 4.86   5 2.18 0.251 15.1, 27.5 -1.26
B6.BKS(D)-Leprdb/J m 48.1 8.19   6 3.34 0.17 34.6, 59.3 1.75
B6.Cg-Ay/J f 44.2 9.44   6 3.85 0.214 29.1, 56.4 1.07
B6.Cg-Ay/J m 27.2 9.81   6 4.01 0.36 10.7, 37.8 -0.45
B6.Cg-Lepob/J f 47.7 11.9   5 5.32 0.249 27.8, 57.0 1.58
B6.Cg-Lepob/J m 38.5 13.6   6 5.54 0.352 17.6, 58.0 0.74
BKS.Cg-Dock7m +/+ Leprdb/J f 33.9 11.0   6 4.49 0.325 24.5, 52.6 -0.4
BKS.Cg-Dock7m +/+ Leprdb/J m 27.5 5.54   6 2.26 0.201 22.1, 37.6 -0.41
BKSChpLt.HRS-Cpefat/J f 31.0 6.23   7 2.36 0.201 24.1, 42.4 -0.81
BKSChpLt.HRS-Cpefat/J m 25.9 7.63   6 3.12 0.295 15.9, 37.9 -0.58
C57BL/6J f 37.2 10.4   7 3.93 0.28 23.5, 54.0 0.07
C57BL/6J m 39.5 6.68   6 2.73 0.169 31.9, 50.4 0.84
C57BLKS/J f 34.5 4.79   5 2.14 0.139 27.2, 39.9 -0.31
C57BLKS/J m 25.5 10.1   7 3.81 0.395 14.1, 44.5 -0.62


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 28.34 3.9942 36.3082 20.3718
B6(AU)-Tubtub/J m 19.38 3.9942 27.3482 11.4118
B6.Cg-Ay/J f 44.1833 3.6462 51.4573 36.9094
B6.Cg-Ay/J m 27.2333 3.6462 34.5073 19.9594
B6.Cg-Lepob/J f 47.68 3.9942 55.6482 39.7118
B6.Cg-Lepob/J m 38.5167 3.6462 45.7906 31.2427
BKS.Cg-Dock7m +/+ Leprdb/J f 33.8667 3.6462 41.1406 26.5927
BKS.Cg-Dock7m +/+ Leprdb/J m 27.4833 3.6462 34.7573 20.2094
BKSChpLt.HRS-Cpefat/J f 31.0429 3.3757 37.7772 24.3085
BKSChpLt.HRS-Cpefat/J m 25.9167 3.6462 33.1906 18.6427
C57BL/6J f 37.2143 3.3757 43.9487 30.4799
C57BL/6J m 39.4667 3.6462 46.7406 32.1927
C57BLKS/J f 34.54 3.9942 42.5082 26.5718
C57BLKS/J m 25.5429 3.3757 32.2772 18.8085


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 23.86 2.8243 29.4944 18.2256
B6.Cg-Ay/J both 35.7083 2.5783 40.8518 30.5649
B6.Cg-Lepob/J both 43.0983 2.7041 48.4929 37.7038
BKS.Cg-Dock7m +/+ Leprdb/J both 30.675 2.5783 35.8185 25.5315
BKSChpLt.HRS-Cpefat/J both 28.4798 2.4845 33.4361 23.5234
C57BL/6J both 38.3405 2.4845 43.2969 33.3841
C57BLKS/J both 30.0414 2.6148 35.2579 24.825




GWAS analysis not available: At least 12 strains are required