Paigen1: Diet effects on gallstone formation and the assessment of liver morphology, plasma lipids, and atherosclerosis in 44 inbred strains of mice on high-fat atherogenic diet (not under pathogen-free conditions) (2000)

Paigen B, Bouchard G, Carey MC   With: Johnson D, Tovbina M, Silva A, Carver T, Tracy T, McFarland C, Archer J, Whitmore H

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Investigators Beverly Paigen       The Jackson Laboratory,  Bar Harbor, ME
Guylaine Bouchard       Hopital Ste-Justine,  Montreal, Quebec CANADA
Martin C Carey       Harvard Medical School,  Boston, MA
Participants Johnson D, Tovbina M, Silva A, Carver T, Tracy T, McFarland C, Archer J, Whitmore H
ContactBeverly Paigen
Affiliated CenterJAX Heart, Lung, and Blood Center (HLB)
Part of a series: • Inbred strains   (this project) Paigen1
• Obesity mutant strains   see Paigen3
AcknowledgementsFunding provided by NIH DK51568, NHLBI PGA HL66611, DK36588, DK34854, DK52911; Medical Research Council of Canada

Generous funds from Aventis Pharmaceuticals Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersPaigen1     MPD:29
Data changelog 8 updates/corrections.       Initial release date: 02/2001.
Formatted citation
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All animals were fed a high-fat (15% fat) diet for 8 wks. Blood chemistry and cholesterol were measured. After sac, a pathology review of livers and gallbladders was conducted. A collection of liver images is available as part of this project.

Procedures conducted:
• body weight  Baseline vs. high-fat diet for 8wks.
• lipid profile  Cholesterol, HDL, non-HDL. 4h fast, plasma. Hepatic lipids. 8wks on high-fat diet.
• metabolic panel  Alanine transaminase, bile salts (plasma) after 8wks on high-fat diet. 4h fast.
• histopathology  Gallstone, gallbladder, and atherosclerosis lesion histopathology after 8wks on high-fat diet.
• organ dimensions  Gallbladder volume after 8wks on high-fat diet.
• organ weights  Liver weight after 8wks on high-fat diet.

Mice: inbred   44 strains   ♀♂   age 15-19wks   1 experimental group