Project measure / variable:   Rusyn6   BrdU_liver_tce

ID, description, units MPD:51214   BrdU_liver_tce   BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group   [%]  
trichloroethylene study
Data set, strains Rusyn6   inbred   7 strains     sex: m     age: 6-7wks
Procedure histopathology
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  STRAIN COMPARISON PLOT
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Rusyn6 - BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested7 strains
Mean of the strain means5.06   %
Median of the strain means2.27   %
SD of the strain means± 7.73
Coefficient of variation (CV)1.53
Min–max range of strain means0.767   –   22.4   %
Mean sample size per strain3.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 6 1374.2112 229.0352 4.9878 0.0041
Residuals 17 780.6183 45.9187


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 2.83 2.92   3 1.68 1.03 1.1, 6.2 -0.29
A/J m 0.767 0.513   3 0.296 0.669 0.2, 1.2 -0.56
BTBR T+ Itpr3tf/J m 22.4 15.5   4 7.75 0.692 7.6, 43.9 2.24
C57BL/6J m 1.8 1.11   3 0.643 0.619 0.6, 2.8 -0.42
CAST/EiJ m 1.1 0.954   3 0.551 0.867 0.2, 2.1 -0.51
NOD/ShiLtJ m 2.27 2.11   4 1.05 0.926 0.8, 5.4 -0.36
NZW/LacJ m 4.25 2.91   4 1.45 0.685 1.9, 8.1 -0.1


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 2.8333 3.9123 11.0876 0.0
A/J m 0.7667 3.9123 9.0209 0.0
BTBR T+ Itpr3tf/J m 22.375 3.3882 29.5234 15.2266
C57BL/6J m 1.8 3.9123 10.0543 0.0
CAST/EiJ m 1.1 3.9123 9.3543 0.0
NOD/ShiLtJ m 2.275 3.3882 9.4234 0.0
NZW/LacJ m 4.25 3.3882 11.3984 0.0




  GWAS USING LINEAR MIXED MODELS