MPD: Data set: Sunde1

Sunde RA. Selenium regulation of selenoprotein enzyme activity and transcripts in a pilot study with Founder strains from the Collaborative Cross. PLoS One. 2018 Jan 16;13(1):e0191449. doi: 10.1371/journal.pone.0191449. eCollection 2018. PubMed 29338053 FullText

Sunde1 downloads
• Download Sunde1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Sunde1 measures:

MA:0000059 blood
MA:0000358 liver
MA:0002501 plasma
MP:0000609 abnormal liver physiology
MP:0001259 abnormal body weight
MP:0003656 abnormal erythrocyte physiology
MP:0008872 abnormal physiological response to xenobiotic
VT:0000609 liver physiology trait
VT:0001259 body mass
VT:0003656 erythrocyte physiology trait
VT:0010487 response to xenobiotic stimulus trait

Investigators	Roger A Sunde University of Wisconsin, Madison, WI
Contact	Roger A Sunde sunde@nutrisci.wisc.edu
Acknowledgements	Funding provided by Wisconsin Alumni Foundation Selenium Nutrition Research Fund (No. 12046295)
Project type	Phenotype strain survey data set
MPD identifiers	Sunde1 MPD:653
Data changelog	No updates/corrections. Initial release date: 04/2019.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

The "selenium sufficient" group was given selenium food supplement.

The "selenium deficient" group were not given any supplement and are naive mice.

Procedures conducted:

• body weight		Body weight curve 3 to 12 wks, control group.
• RNA expression profiling		Selenium regulation of selenoprotein enzyme activity and transcripts.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Sunde1:1	Sunde1	body weight	(none)	body weight [g] bw 65301 day 20 day 28 day 35 day 42 day 49 day 56 day 63 day 70 day 77 day 84	inbred w/CC8	8	m	3-12wks	N=3

Sunde1:11	Sunde1	RNA expression profiling	selenium	liver Dio1, mRNA abundance relative to C57BL/6J +Se [%] Dio1_mRNA 65311 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:13	Sunde1	RNA expression profiling	selenium	liver Gpx1, mRNA abundance relative to C57BL/6J +Se [%] Gpx1_mRNA 65313 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:15	Sunde1	RNA expression profiling	selenium	liver Gpx3, mRNA abundance relative to C57BL/6J +Se [%] Gpx3_mRNA 65315 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:17	Sunde1	RNA expression profiling	selenium	liver Gpx4, mRNA abundance relative to C57BL/6J +Se [%] Gpx4_mRNA 65317 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:19	Sunde1	RNA expression profiling	selenium	liver Msrb1, mRNA abundance relative to C57BL/6J +Se [%] Msrb1_mRNA 65319 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:21	Sunde1	RNA expression profiling	selenium	liver Selenof, mRNA abundance relative to C57BL/6J +Se [%] Selenof_mRNA 65321 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:23	Sunde1	RNA expression profiling	selenium	liver Selenoh, mRNA abundance relative to C57BL/6J +Se [%] Selenoh_mRNA 65323 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:25	Sunde1	RNA expression profiling	selenium	liver Selenok, mRNA abundance relative to C57BL/6J +Se [%] Selenok_mRNA 65325 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:27	Sunde1	RNA expression profiling	selenium	liver Selenom, mRNA abundance relative to C57BL/6J +Se [%] Selenom_mRNA 65327 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:29	Sunde1	RNA expression profiling	selenium	liver Selenon, mRNA abundance relative to C57BL/6J +Se [%] Selenon_mRNA 65329 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:31	Sunde1	RNA expression profiling	selenium	liver Selenoo, mRNA abundance relative to C57BL/6J +Se [%] Selenoo_mRNA 65331 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:33	Sunde1	RNA expression profiling	selenium	liver Selenop, mRNA abundance relative to C57BL/6J +Se [%] Selenop_mRNA 65333 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:35	Sunde1	RNA expression profiling	selenium	liver Selenos, mRNA abundance relative to C57BL/6J +Se [%] Selenos_mRNA 65335 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:37	Sunde1	RNA expression profiling	selenium	liver Selenot, mRNA abundance relative to C57BL/6J +Se [%] Selenot_mRNA 65337 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:39	Sunde1	RNA expression profiling	selenium	liver Selenow, mRNA abundance relative to C57BL/6J +Se [%] Selenow_mRNA 65339 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:41	Sunde1	RNA expression profiling	selenium	liver Txnrd1, mRNA abundance relative to C57BL/6J +Se [%] Txnrd1_mRNA 65341 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:43	Sunde1	RNA expression profiling	selenium	liver Txnrd2, mRNA abundance relative to C57BL/6J +Se [%] Txnrd2_mRNA 65343 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:45	Sunde1	RNA expression profiling	selenium	liver Txnrd3, mRNA abundance relative to C57BL/6J +Se [%] Txnrd3_mRNA 65345 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:47	Sunde1	protein activity assessment	selenium	liver Gpx1 enzyme activity (EU/g protein) [EU/g] Gpx1_act_liv 65347 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:49	Sunde1	protein activity assessment	selenium	RBC Gpx1 enzyme activity (EU/g protein) [EU/g] Gpx1_act_rbc 65349 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:51	Sunde1	protein activity assessment	selenium	plasma Gpx3 enzyme activity (EU/g protein) [EU/g] Gpx3_act 65351 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:53	Sunde1	protein activity assessment	selenium	liver Gpx4 enzyme activity (EU/g protein) [EU/g] Gpx4_act 65353 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:55	Sunde1	protein activity assessment	selenium	liver Txnrd enzyme activity (EU/g protein) [EU/g] Txnrd_act 65355 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1: Selenium regulation of selenoprotein enzyme activity and transcripts in 8 inbred founder strains of the Collaborative Cross (2018)