MPD: Data set: Sunde1

Sunde RA. Selenium regulation of selenoprotein enzyme activity and transcripts in a pilot study with Founder strains from the Collaborative Cross. PLoS One. 2018 Jan 16;13(1):e0191449. doi: 10.1371/journal.pone.0191449. eCollection 2018. PubMed 29338053 FullText

The "selenium sufficient" group was given selenium food supplement.

The "selenium deficient" group were not given any supplement and are naive mice.

Procedures conducted:

• body weight		Body weight curve 3 to 12 wks, control group.
• RNA expression profiling		Selenium regulation of selenoprotein enzyme activity and transcripts.

Sunde1 downloads
• Download Sunde1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Sunde1 measures:

MA:0000059 blood
MA:0000358 liver
MA:0002501 plasma
MP:0000609 abnormal liver physiology
MP:0001259 abnormal body weight
MP:0003656 abnormal erythrocyte physiology
MP:0008872 abnormal physiological response to xenobiotic
VT:0000609 liver physiology trait
VT:0001259 body mass
VT:0003656 erythrocyte physiology trait
VT:0010487 response to xenobiotic stimulus trait

Investigators	Roger A Sunde University of Wisconsin, Madison, WI
Contact	Roger A Sunde sunde@nutrisci.wisc.edu
Acknowledgements	Funding provided by Wisconsin Alumni Foundation Selenium Nutrition Research Fund (No. 12046295)
Project type	Phenotype strain survey data set
MPD identifiers	Sunde1 MPD:653
Data changelog	No updates/corrections. Initial release date: 04/2019.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Sunde1:1	Sunde1	body weight	(none)	body weight [g] bw 65301 day 20 day 28 day 35 day 42 day 49 day 56 day 63 day 70 day 77 day 84	inbred w/CC8	8	m	3-12wks	N=3

Sunde1:11	Sunde1	RNA expression profiling	selenium	liver Dio1, mRNA abundance relative to C57BL/6J +Se [%] Dio1_mRNA 65311 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:13	Sunde1	RNA expression profiling	selenium	liver Gpx1, mRNA abundance relative to C57BL/6J +Se [%] Gpx1_mRNA 65313 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:15	Sunde1	RNA expression profiling	selenium	liver Gpx3, mRNA abundance relative to C57BL/6J +Se [%] Gpx3_mRNA 65315 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:17	Sunde1	RNA expression profiling	selenium	liver Gpx4, mRNA abundance relative to C57BL/6J +Se [%] Gpx4_mRNA 65317 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:19	Sunde1	RNA expression profiling	selenium	liver Msrb1, mRNA abundance relative to C57BL/6J +Se [%] Msrb1_mRNA 65319 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:21	Sunde1	RNA expression profiling	selenium	liver Selenof, mRNA abundance relative to C57BL/6J +Se [%] Selenof_mRNA 65321 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:23	Sunde1	RNA expression profiling	selenium	liver Selenoh, mRNA abundance relative to C57BL/6J +Se [%] Selenoh_mRNA 65323 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:25	Sunde1	RNA expression profiling	selenium	liver Selenok, mRNA abundance relative to C57BL/6J +Se [%] Selenok_mRNA 65325 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:27	Sunde1	RNA expression profiling	selenium	liver Selenom, mRNA abundance relative to C57BL/6J +Se [%] Selenom_mRNA 65327 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:29	Sunde1	RNA expression profiling	selenium	liver Selenon, mRNA abundance relative to C57BL/6J +Se [%] Selenon_mRNA 65329 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:31	Sunde1	RNA expression profiling	selenium	liver Selenoo, mRNA abundance relative to C57BL/6J +Se [%] Selenoo_mRNA 65331 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:33	Sunde1	RNA expression profiling	selenium	liver Selenop, mRNA abundance relative to C57BL/6J +Se [%] Selenop_mRNA 65333 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:35	Sunde1	RNA expression profiling	selenium	liver Selenos, mRNA abundance relative to C57BL/6J +Se [%] Selenos_mRNA 65335 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:37	Sunde1	RNA expression profiling	selenium	liver Selenot, mRNA abundance relative to C57BL/6J +Se [%] Selenot_mRNA 65337 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:39	Sunde1	RNA expression profiling	selenium	liver Selenow, mRNA abundance relative to C57BL/6J +Se [%] Selenow_mRNA 65339 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:41	Sunde1	RNA expression profiling	selenium	liver Txnrd1, mRNA abundance relative to C57BL/6J +Se [%] Txnrd1_mRNA 65341 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:43	Sunde1	RNA expression profiling	selenium	liver Txnrd2, mRNA abundance relative to C57BL/6J +Se [%] Txnrd2_mRNA 65343 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:45	Sunde1	RNA expression profiling	selenium	liver Txnrd3, mRNA abundance relative to C57BL/6J +Se [%] Txnrd3_mRNA 65345 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:47	Sunde1	protein activity assessment	selenium	liver Gpx1 enzyme activity (EU/g protein) [EU/g] Gpx1_act_liv 65347 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:49	Sunde1	protein activity assessment	selenium	RBC Gpx1 enzyme activity (EU/g protein) [EU/g] Gpx1_act_rbc 65349 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:51	Sunde1	protein activity assessment	selenium	plasma Gpx3 enzyme activity (EU/g protein) [EU/g] Gpx3_act 65351 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:53	Sunde1	protein activity assessment	selenium	liver Gpx4 enzyme activity (EU/g protein) [EU/g] Gpx4_act 65353 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1:55	Sunde1	protein activity assessment	selenium	liver Txnrd enzyme activity (EU/g protein) [EU/g] Txnrd_act 65355 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1

Sunde1: Selenium regulation of selenoprotein enzyme activity and transcripts in 8 inbred founder strains of the Collaborative Cross (2018)