Schonfeld1: Strain survey of liver and plasma lipids and blood glucose levels in 11 inbred strains of mice (2005)

Lin X, Yue P, Chen Z, Schonfeld G. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1179-89. Epub 2004 Dec 9.   PubMed 15591160  


         
An investigation of liver triglyceride (TG) levels and development of fatty liver following fasting. Animals were surveyed for blood glucose/insulin metabolism and tolerance, blood and liver lipid metabolism, liver and body weights, and overall fat composition. An analysis (3 strains) of the effect of different fasting times (0h, 6h, 14h) for BHB, FFA, and hTG is available here.

Procedures conducted:
• body weight 
• glucose tolerance  0 to 120 min after 10% glucose i.p. 5h fast.
• insulin tolerance  0 to 120 min after insulin i.p. 5h fast.
• lipid profile  Cholesterol, triglycerides, free fatty acids, phospholipids. 5h fast, plasma. Hepatic triglycerides.
• metabolic panel  Glucose, beta-hydroxybutyrate (plasma). No fast.
• organ weights  Liver weight.
• DXA  Fat mass.
• hormone quantification  Insulin level, 30 min post-injection in glucose tolerance test. 10% glucose. 5h fast.

Schonfeld1 downloads
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• Schonfeld1 supplementary data
Investigators Gustav Schonfeld       Washington University School of Medicine,  St. Louis, MO
Participants Lin X, Yue P, and Chen Z
ContactGustav Schonfeld     gschonfe@wustl.edu
AcknowledgementsFunding provided by NIH HL42446, HL59515, HL52139, RR00036, DK20579, DK56341, DK52574

Support from the following sources: Alan and Edith Wolf Charitable Fund
Project type Phenotype strain survey data set
MPD identifiersSchonfeld1     MPD:323
Data changelog 1 update/correction.       Initial release date: 12/2009.
Formatted citation
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Mice: inbred   11 strains   ♀♂   age 8-10wks   1 experimental group

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Schonfeld1 metabolic panel (none) glucose (plasma GLU, no fast)   [mg/dL]  GLU   32301     inbred 11 both 9-13wks N=6
    Schonfeld1 glucose tolerance (none) glucose levels during glucose tolerance test(10% glucose i.p., 5h fast)   [mg/dL]  GTT   32303     0 min    30 min    60 min    120 min inbred 10 both 9-13wks N=5
    Schonfeld1 glucose tolerance (none) glucose levels, area under curve, glucose tolerance test (10% glucose i.p., 5h fast)   [AUC]  AUC_GTT   32308     0 to 60 min    0 to 120 min inbred 10 both 9-13wks N=5
    Schonfeld1 hormone quantification (none) insulin level (plasma), 30 min post injection in glucose tolerance test (10% glucose i.p., 5h fast)   [ng/mL]  Insulin   32311     inbred 10 both 9-13wks N=5
    Schonfeld1 insulin tolerance (none) glucose levels as percent of baseline, insulin tolerance test (human insulin 0.75 U/kg bw i.p., 5h fast)   [%]  pct_ITT   32313     0 min    30 min    60 min    120 min inbred 10 both 9-13wks N=5
    Schonfeld1 insulin tolerance (none) glucose levels, area under curve, insulin tolerance test (human insulin 0.75 U/kg bw i.p., 5h fast)   [AUC]  AUC_ITT   32318     0 to 60 min    0 to 120 min inbred 10 both 9-13wks N=5
    Schonfeld1 lipid profile (none) total cholesterol (plasma CHOL)   [mg/dL]  TC   32331     inbred 11 both 9-13wks N=6
    Schonfeld1 lipid profile (none) free cholesterol (plasma)   [mg/dL]  FC   32332     inbred 10 both 9-13wks N=6
    Schonfeld1 lipid profile (none) cholesterol ester (plasma)   [mg/dL]  CE   32333     inbred 10 both 9-13wks N=6
    Schonfeld1 lipid profile (none) free fatty acids (plasma FFA)   [mol/m3]  FFA   32334     inbred 10 both 9-13wks N=5
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