Schonfeld1: Strain survey of liver and plasma lipids and blood glucose levels in 11 inbred strains of mice (2005)

Lin X, Yue P, Chen Z, Schonfeld G. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1179-89. Epub 2004 Dec 9.   PubMed 15591160  

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Participants Gustav Schonfeld       Washington University School of Medicine St. Louis, MO
With: Lin X, Yue P, and Chen Z
ContactGustav Schonfeld
AcknowledgementsFunding provided by NIH HL42446, HL59515, HL52139, RR00036, DK20579, DK56341, DK52574

Support from the following sources: Alan and Edith Wolf Charitable Fund
Project type Phenotype strain survey data set
MPD identifiersSchonfeld1     MPD:323
Data changelog 1 update/correction.       Initial release date: 12/2009.
Formatted citation
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An investigation of liver triglyceride (TG) levels and development of fatty liver following fasting. Animals were surveyed for blood glucose/insulin metabolism and tolerance, blood and liver lipid metabolism, liver and body weights, and overall fat composition. An analysis (3 strains) of the effect of different fasting times (0h, 6h, 14h) for BHB, FFA, and hTG is available here.

Summary of procedures that were conducted
• body weight
• glucose tolerance 0 to 120 min after 10% glucose i.p. 5h fast.
• insulin tolerance 0 to 120 min after insulin i.p. 5h fast.
• lipid profile Cholesterol, triglycerides, free fatty acids, phospholipids. 5h fast, plasma. Hepatic triglycerides.
• metabolic panel Glucose, beta-hydroxybutyrate (plasma). No fast.
• organ weights Liver weight.
• DXA Fat mass.
• hormone quantification Insulin level, 30 min post-injection in glucose tolerance test. 10% glucose. 5h fast.
Mice: inbred   11 strains   ♀♂   age 8-10wks   1 cohort