Cheverud1: Diet-induced obesity and diabetes in 19 LGXSM recombinant inbred strains of mice (2004)

Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 2004 Oct;53(10):2700-8.   PubMed 15448104  

Hrbek T, de Brito RA, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome. 2006 May;17(5):417-29.   PubMed 16688532  


           
Notes
Genotypic data (Mit markers) for QTL analysis are available in the supplemental file.

Static graphs are available for the glucose clearance tests.


Cheverud1 downloads
• Download Cheverud1 project data set     one row per animal, one column per trait
• Download Cheverud1 strain means, SD, N, etc.     one row per strain/sex/measure
• Cheverud1 supplementary data
Ontology terms mapped to Cheverud1 measures:
    MA:0000059   blood
    MA:0000072   heart
    MA:0000141   spleen
    MA:0000358   liver
    MA:0000368   kidney
    MA:0000472   abdominal fat pad
    MA:0002481   fat pad
    MA:0002502   serum
    MA:0002547   gonadal fat pad
    MA:0002548   inguinal fat pad
    MA:0002549   retroperitoneal fat pad
    MP:0000180   abnormal circulating cholesterol level
    MP:0001259   abnormal body weight
    MP:0001553   abnormal circulating free fatty acids level
    MP:0001560   abnormal circulating insulin level
    MP:0002089   abnormal postnatal growth/weight/body size
    MP:0002707   abnormal kidney weight
    MP:0004847   abnormal liver weight
    MP:0004857   abnormal heart weight
    MP:0004951   abnormal spleen weight
    MP:0005291   abnormal glucose tolerance
    MP:0005335   abnormal gonadal fat pad morphology
    MP:0005336   abnormal inguinal fat pad morphology
    MP:0005667   abnormal circulating leptin level
    MP:0008902   abnormal renal fat pad morphology
    MP:0008903   abnormal mesenteric fat pad morphology
    MP:0011969   abnormal circulating triglyceride level
    MP:0020130   abnormal total fat pad weight
    VT:0000180   blood cholesterol amount
    VT:0000188   blood glucose amount
    VT:0000689   spleen morphology trait
    VT:0001259   body mass
    VT:0001553   blood free fatty acid amount
    VT:0001560   blood insulin amount
    VT:0001731   postnatal growth trait
    VT:0002644   blood triglyceride amount
    VT:0002707   kidney mass
    VT:0003402   liver mass
    VT:0004951   spleen mass
    VT:0005335   gonadal fat pad morphology trait
    VT:0005336   inguinal fat pad morphology trait
    VT:0005452   adipose amount
    VT:0005667   blood leptin amount
    VT:0007028   heart mass
    VT:0015004   mesenteric fat pad morphology trait
    VT:0015006   renal fat pad morphology trait
    VT:0015008   total fat pad mass
    VT:0015088   glucose metabolism trait
Participants James M Cheverud       Washington University School of Medicine,  St. Louis, MO
With: Hrbek T, de Brito RA, Wang B, Pletscher LS, Ehrich TH, Kenney JP, Semenkovich CF
ContactJames M Cheverud     cheverud@pcg.wustl.edu     Lab web site
AcknowledgementsFunding provided by NIH DK55736, DK52514, HL58427, RR15116, DK56431, DK20579
Project type Phenotype strain survey data set
MPD identifiersCheverud1     MPD:178
Data changelog No updates/corrections.       Initial release date: 11/2008.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
There were 2 cohorts: 1) controls on standard diet; and 2) mice fed a high fat diet (42% calories from fat).

Summary of procedures that were conducted
• body weight Body weight and growth curve from age 1wk to 22wks (pre-wean, post-wean, adult). High-fat diet (17wks) vs. control.
• fat pad weights High-fat diet (17wks) vs. control.
• glucose tolerance High-fat diet (17wks) vs. control. 0 to 120 min after 10% glucose i.p. 4h fast.
• lipid profile Cholesterol, triglycerides, free fatty acids. High-fat diet (17wks) vs. control. 4h fast, serum.
• organ weights Heart, liver, kidney, spleen weights after high-fat diet (17wks) vs. control.
• hormone quantification Insulin, leptin.
Mice: LGXSM w/par   19 strains   ♀♂   age 12-16wks   2 cohorts