Cheverud1: Diet-induced obesity and diabetes in 19 LGXSM recombinant inbred strains of mice (2004)

Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 2004 Oct;53(10):2700-8.   PubMed 15448104  

Hrbek T, de Brito RA, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome. 2006 May;17(5):417-29.   PubMed 16688532  


         
Notes
Genotypic data (Mit markers) for QTL analysis are available in the supplemental file.

Static graphs are available for the glucose clearance tests.


Cheverud1 downloads
• Download Cheverud1 project data set     one row per animal, one column per trait
• Download Cheverud1 strain means, SD, N, etc.     one row per strain/sex/measure
• Cheverud1 supplementary data
Participants James M Cheverud       Washington University School of Medicine St. Louis, MO
With: Hrbek T, de Brito RA, Wang B, Pletscher LS, Ehrich TH, Kenney JP, Semenkovich CF
ContactJames M Cheverud     cheverud@pcg.wustl.edu     Lab web site
AcknowledgementsFunding provided by NIH DK55736, DK52514, HL58427, RR15116, DK56431, DK20579
Project type Phenotype strain survey data set
MPD identifiersCheverud1     MPD:178
Data changelog No updates/corrections.       Initial release date: 11/2008.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
There were 2 cohorts: 1) controls on standard diet; and 2) mice fed a high fat diet (42% calories from fat).

Summary of procedures that were conducted
• body weight Body weight and growth curve from age 1wk to 22wks (pre-wean, post-wean, adult). High-fat diet (17wks) vs. control.
• fat pad weights High-fat diet (17wks) vs. control.
• glucose tolerance High-fat diet (17wks) vs. control. 0 to 120 min after 10% glucose i.p. 4h fast.
• lipid profile Cholesterol, triglycerides, free fatty acids. High-fat diet (17wks) vs. control. 4h fast, serum.
• organ weights Heart, liver, kidney, spleen weights after high-fat diet (17wks) vs. control.
• hormone quantification Insulin, leptin.
Mice: LGXSM w/par   19 strains   ♀♂   age 12-16wks   2 cohorts