Phenotype measure:   Paigen3   free_to_est

ID, description, units MPD:2829   free_to_est   hepatic cholesterol concentration (free to esterified ratio)   [ratio]
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure lipid profile
Ontology mappings

  STRAIN COMPARISON PLOT
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Paigen3 - hepatic cholesterol concentration (free to esterified ratio)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means0.151   ratio 0.198   ratio
Median of the strain means0.146   ratio 0.194   ratio
SD of the strain means± 0.0285 ± 0.0324
Coefficient of variation (CV)0.188 0.163
Min–max range of strain means0.112   –   0.192   ratio 0.153   –   0.245   ratio
Mean sample size per strain5.9   mice 5.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0446 0.0446 9.9002 0.0025
strain 6 0.0438 0.0073 1.6223 0.1544
sex:strain 6 0.0249 0.0041 0.9211 0.4854
Residuals 68 0.3062 0.0045


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 0.192 0.13   5 0.058 0.675 0.079, 0.404 1.42
B6(AU)-Tubtub/J m 0.245 0.0865   5 0.0387 0.352 0.129, 0.369 1.44
B6.BKS(D)-Leprdb/J m 0.192 0.0342   6 0.014 0.178 0.147, 0.241 -0.2
B6.Cg-Ay/J f 0.129 0.0515   6 0.021 0.399 0.08, 0.223 -0.79
B6.Cg-Ay/J m 0.229 0.106   6 0.0434 0.464 0.13, 0.435 0.95
B6.Cg-Lepob/J f 0.146 0.0465   5 0.0208 0.318 0.097, 0.222 -0.19
B6.Cg-Lepob/J m 0.195 0.0886   6 0.0362 0.454 0.118, 0.365 -0.1
BKS.Cg-Dock7m +/+ Leprdb/J f 0.171 0.0623   6 0.0254 0.364 0.113, 0.28 0.69
BKS.Cg-Dock7m +/+ Leprdb/J m 0.224 0.0592   6 0.0242 0.264 0.145, 0.301 0.79
BKSChpLt.HRS-Cpefat/J f 0.174 0.0439   7 0.0166 0.252 0.134, 0.269 0.79
BKSChpLt.HRS-Cpefat/J m 0.162 0.0413   6 0.0169 0.255 0.1, 0.202 -1.12
C57BL/6J f 0.136 0.0387   7 0.0146 0.285 0.09, 0.2 -0.54
C57BL/6J m 0.153 0.0197   6 0.00803 0.128 0.13, 0.17 -1.4
C57BLKS/J f 0.112 0.0268   5 0.012 0.24 0.07, 0.14 -1.38
C57BLKS/J m 0.187 0.0638   6 0.026 0.342 0.1, 0.29 -0.35


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 0.1922 0.03 0.2521 0.1323
B6(AU)-Tubtub/J m 0.2454 0.03 0.3053 0.1855
B6.Cg-Ay/J f 0.1292 0.0274 0.1838 0.0745
B6.Cg-Ay/J m 0.2295 0.0274 0.2842 0.1748
B6.Cg-Lepob/J f 0.1462 0.03 0.2061 0.0863
B6.Cg-Lepob/J m 0.1952 0.0274 0.2498 0.1405
BKS.Cg-Dock7m +/+ Leprdb/J f 0.171 0.0274 0.2257 0.1163
BKS.Cg-Dock7m +/+ Leprdb/J m 0.2243 0.0274 0.279 0.1697
BKSChpLt.HRS-Cpefat/J f 0.1739 0.0254 0.2245 0.1232
BKSChpLt.HRS-Cpefat/J m 0.1618 0.0274 0.2165 0.1072
C57BL/6J f 0.1357 0.0254 0.1863 0.0851
C57BL/6J m 0.1533 0.0274 0.208 0.0987
C57BLKS/J f 0.112 0.03 0.1719 0.0521
C57BLKS/J m 0.1867 0.0274 0.2413 0.132


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 0.2188 0.0212 0.2611 0.1765
B6.Cg-Ay/J both 0.1793 0.0194 0.218 0.1407
B6.Cg-Lepob/J both 0.1707 0.0203 0.2112 0.1301
BKS.Cg-Dock7m +/+ Leprdb/J both 0.1977 0.0194 0.2363 0.159
BKSChpLt.HRS-Cpefat/J both 0.1678 0.0187 0.2051 0.1306
C57BL/6J both 0.1445 0.0187 0.1818 0.1073
C57BLKS/J both 0.1493 0.0203 0.1899 0.1088




GWAS analysis not available: At least 12 strains are required