MPD: Project measures / variables set: Threadgill2 GSH

Project measures / variables set: Threadgill2 GSH_pct

ID, description, units	MPD:39606 GSH_pct percent reduced glutathione [%] acetaminophen study
Measures	• control • post-Rx 300 mg/kg
Data set, strains	Threadgill2 inbred 5 strains sex: m age: 6-8wks
Procedure	metabolite quantification
Comparison	control group vs. treated group
Ontology mappings	VT:0000609 liver physiology trait VT:0010487 response to xenobiotic stimulus trait VT:0010516 blood glutathione amount MA:0000358 liver MP:0008872 abnormal physiological response to xenobiotic MP:0011601 abnormal glutathione peroxidase activity

Values Means Δ Means Z-scores

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Threadgill2 - percent reduced glutathione

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	7045.912	7045.912	11.6727	0.0018
group:strain	4	960.1466	240.0366	0.3977	0.8087
Residuals	30	18108.6627	603.6221
strain	4	19822.9385	4955.7346	8.21	0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill2	39606	metabolite quantification	acetaminophen	percent reduced glutathione [%] control GSH_pct_ctr	inbred	5	m	6-8wks
Threadgill2	39630	metabolite quantification	acetaminophen	percent reduced glutathione [%] post-Rx 300 mg/kg GSH_pct_Rx300	inbred	5	m	6-8wks