Bopp1: Susceptibility to infection with Plasmodium berghei (malaria) in 31 inbred mouse strains (2010)

Bopp SE, Ramachandran V, Henson K, Luzader A, Lindstrom M, Spooner M, Steffy BM, Suzuki O, Janse C, Waters AP, Zhou Y, Wiltshire T, Winzeler EA. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. PLoS One. 2010 May 28;5(5):e10903.   PubMed 20531941     FullText


       
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Participants Selina ER Bopp       The Scripps Research Institute La Jolla, CA
Vandana Ramachandran       The Scripps Research Institute La Jolla, CA
Tim Wiltshire       University of North Carolina Chapel Hill, NC
Elizabeth A Winzeler       The Scripps Research Institute La Jolla, CA
With: Henson K, Luzader A, Lindstrom M, Spooner M, Steffy BM, Suzuki O, Janse C, Waters AP, Zhou Y
ContactSelina ER Bopp     selina@scripps.edu     Lab web site
AcknowledgementsFunding provided by the WM Keck Foundation
Project type Phenotype strain survey data set
MPD identifiersBopp1     MPD:364
Data changelog No updates/corrections.       Initial release date: 04/2011.
Formatted citation
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Summary of procedures that were conducted
• health assessment Susceptibility, Plasmodium berghei (malaria). Parasitemia in blood and distribution in brain, spleen, lungs, liver.
Mice: inbred   31 strains   ♀♂   age 8-12wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Bopp1 36401 health assessment Plasmodium berghei survival, post-infection   [d]  survival inbred 31 both 8-12wks N=4
    Bopp1 36402 health assessment Plasmodium berghei terminal body temperature, post-infection   [°C]  body_temp inbred 31 both 8-12wks N=4
    Bopp1 36403 health assessment Plasmodium berghei percentage of parasite-infected erythrocytes in blood   [%]  parasitemia inbred 31 both 8-12wks N=4
    Bopp1 36404 health assessment Plasmodium berghei percentage of parasites in brain relative to all organs tested   [%]  luciferase_brain inbred 26 both 8-12wks N=2
    Bopp1 36405 health assessment Plasmodium berghei percentage of parasites in spleen relative to all organs tested   [%]  luciferase_spleen inbred 26 both 8-12wks N=2
    Bopp1 36406 health assessment Plasmodium berghei percentage of parasites in lungs relative to all organs tested   [%]  luciferase_lungs inbred 26 both 8-12wks N=2
    Bopp1 36407 health assessment Plasmodium berghei percentage of parasites in liver relative to all organs tested   [%]  luciferase_liver inbred 26 both 8-12wks N=2
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