Wittenburg3: Plasma lipids, cholesterol gallstones, and related gallstone phenotypes in an intercross between DBA/2J and PERA/EiJ (2005)

References   (chronological)

1.   Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA. Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping. Genetics. 2005 Mar;169(3):1699-709. Epub 2005 Jan 16.   PubMed 15654110     FullText

2.   Wittenburg H, Lyons MA, Li R, Kurtz U, Mössner J, Churchill GA, Carey MC, Paigen B. Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice. Mamm Genome. 2005 Jul;16(7):495-504.   PubMed 16151694  

3.   Wittenburg H, Lyons MA, Li R, Kurtz U, Wang X, Mössner J, Churchill GA, Carey MC, Paigen B. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006 Aug;47(8):1780-90. Epub 2006 May 9.   PubMed 16685081  


     
Wittenburg3 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants H Wittenberg
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Lyons MA, Li R, Kurtz U, Mössner J, Carey MC, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by DK51568, DK36588, DK52911, DK34854, DK73687, GM70683, HL55001; and the American Physiological Society, American Liver Foundation, National Health and Medical Research Council of Australia, the Gastroenterological Society of Australia and Deutsche Forschungsgemeinschaft.
Project type QTL Archive data set
MPD identifiersWittenburg3     MPD:182
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross between DBA/2J and PERA/EiJ was generated to identify QTLs for cholesterol gallstone susceptibility. At 6-8 wks of age, backcross progeny of both sexes were administered a high-fat (15%) diet for 8 wks and examined for gallstone formation and related phenotypes. Mice were fasted prior to sample collection. For detailed protocols see Wittenburg et al 2005.


QTL data set parameters:
Progenitor strains DBA/2J     PERA/EiJ    
Cross direction notation(PERAxDBA) F1 x (PERAxDBA) F1; (DBAxPERA) F1 x (DBAxPERA) F1
Cross typeF2 intercross
Population size 166 ♀     158 ♂
Age14-16wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Hdlq10   Hdlq33   Hdlq34   Hdlq35   Hdlq36   Hdlq37   Hdlq38   Hdlq39   Lith12   Lith14   Lith15   Lith16   Lith17   Lith4   Lith9   Nhdlq10   Nhdlq8   Nhdlq9  


Project / data set:   Wittenburg3     a.k.a. Wittenburg_2005
Excel file:   Data_Description_PERAxDBA_Wittenburg2005.xlsx
CSV file:   Wittenburg2005_PERAxDBA_B37_Data.csv
Readme / text file:   readme_Wittenburg2005.txt