Project measure / variable:   Paigen3   macrovacs

ID, description, units MPD:2831   macrovacs   liver macrovacuoles (score: 0-4)   [score]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   7 strains     sex: both     age: 15-19wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - liver macrovacuoles (score: 0-4)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means0.714   score 0.536   score
Median of the strain means0   score 0   score
SD of the strain means± 1.11 ± 1.12
Coefficient of variation (CV)1.56 2.09
Min–max range of strain means0   –   3.00   score 0   –   3.00   score
Mean sample size per strain3.0   mice 3.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.3063 0.3063 11.8417 0.0018
strain 6 43.7303 7.2884 281.8172 < 0.0001
sex:strain 6 1.26 0.21 8.12 < 0.0001
Residuals 29 0.75 0.0259


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 1.0 0.0   3 0.0 0.0 1.0, 1.0 0.26
B6(AU)-Tubtub/J m 0.75 0.5   4 0.25 0.667 0.19
B6.Cg-Ay/J f 0.0 0.0   3 0.0 0.0 -0.64
B6.Cg-Ay/J m 0.0 0.0   3 0.0 0.0 -0.48
B6.Cg-Lepob/J f 3.0 0.0   3 0.0 0.0 3.0, 3.0 2.05
B6.Cg-Lepob/J m 3.0 0.0   3 0.0 0.0 3.0, 3.0 2.2
BKS.Cg-Dock7m +/+ Leprdb/J f 1.0 0.0   3 0.0 0.0 1.0, 1.0 0.26
BKS.Cg-Dock7m +/+ Leprdb/J m 0.0 0.0   3 0.0 0.0 -0.48
BKSChpLt.HRS-Cpefat/J f 0.0 0.0   3 0.0 0.0 -0.64
BKSChpLt.HRS-Cpefat/J m 0.0 0.0   3 0.0 0.0 -0.48
C57BL/6J f 0.0 0.0   3 0.0 0.0 -0.64
C57BL/6J m 0.0 0.0   3 0.0 0.0 -0.48
C57BLKS/J f 0.0 0.0   3 0.0 0.0 -0.64
C57BLKS/J m 0.0 0.0   3 0.0 0.0 -0.48


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 1.0 0.0928 1.1899 0.8101
B6(AU)-Tubtub/J m 0.75 0.0804 0.9145 0.5855
B6.Cg-Ay/J f 0.0 0.0928 0.1899 -0.1899
B6.Cg-Ay/J m 0.0 0.0928 0.1899 -0.1899
B6.Cg-Lepob/J f 3.0 0.0928 3.1899 2.8101
B6.Cg-Lepob/J m 3.0 0.0928 3.1899 2.8101
BKS.Cg-Dock7m +/+ Leprdb/J f 1.0 0.0928 1.1899 0.8101
BKS.Cg-Dock7m +/+ Leprdb/J m 0.0 0.0928 0.1899 -0.1899
BKSChpLt.HRS-Cpefat/J f 0.0 0.0928 0.1899 -0.1899
BKSChpLt.HRS-Cpefat/J m 0.0 0.0928 0.1899 -0.1899
C57BL/6J f 0.0 0.0928 0.1899 -0.1899
C57BL/6J m 0.0 0.0928 0.1899 -0.1899
C57BLKS/J f 0.0 0.0928 0.1899 -0.1899
C57BLKS/J m 0.0 0.0928 0.1899 -0.1899


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 0.875 0.0614 1.0006 0.7494
B6.Cg-Ay/J both 0.0 0.0657 0.1343 -0.1343
B6.Cg-Lepob/J both 3.0 0.0657 3.1343 2.8657
BKS.Cg-Dock7m +/+ Leprdb/J both 0.5 0.0657 0.6343 0.3657
BKSChpLt.HRS-Cpefat/J both 0.0 0.0657 0.1343 -0.1343
C57BL/6J both 0.0 0.0657 0.1343 -0.1343
C57BLKS/J both 0.0 0.0657 0.1343 -0.1343




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA