Project measure / variable:   Paigen3   inflammation

ID, description, units MPD:2832   inflammation   liver inflammation (score: 0-4)   [score]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   7 strains     sex: both     age: 15-19wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - liver inflammation (score: 0-4)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means1.33   score 1.17   score
Median of the strain means1.33   score 1.33   score
SD of the strain means± 0.609 ± 0.788
Coefficient of variation (CV)0.457 0.675
Min–max range of strain means0.333   –   2.00   score 0.333   –   2.33   score
Mean sample size per strain3.0   mice 3.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.4168 0.4168 0.6362 0.4316
strain 6 12.3009 2.0502 3.1292 0.0173
sex:strain 6 5.9567 0.9928 1.5153 0.2083
Residuals 29 19.0 0.6552


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 2.0 1.0   3 0.577 0.5 1.0, 3.0 1.09
B6(AU)-Tubtub/J m 0.5 0.577   4 0.289 1.15 -0.85
B6.Cg-Ay/J f 1.33 0.577   3 0.333 0.433 1.0, 2.0 -0.01
B6.Cg-Ay/J m 2.33 1.15   3 0.667 0.495 1.0, 3.0 1.48
B6.Cg-Lepob/J f 0.333 0.577   3 0.333 1.73 -1.64
B6.Cg-Lepob/J m 0.333 0.577   3 0.333 1.73 -1.06
BKS.Cg-Dock7m +/+ Leprdb/J f 1.0 1.0   3 0.577 1.0 -0.55
BKS.Cg-Dock7m +/+ Leprdb/J m 0.333 0.577   3 0.333 1.73 -1.06
BKSChpLt.HRS-Cpefat/J f 1.67 0.577   3 0.333 0.346 1.0, 2.0 0.55
BKSChpLt.HRS-Cpefat/J m 1.67 0.577   3 0.333 0.346 1.0, 2.0 0.64
C57BL/6J f 1.0 0.0   3 0.0 0.0 1.0, 1.0 -0.55
C57BL/6J m 1.33 1.53   3 0.882 1.15 0.21
C57BLKS/J f 2.0 0.0   3 0.0 0.0 2.0, 2.0 1.09
C57BLKS/J m 1.67 1.15   3 0.667 0.693 1.0, 3.0 0.64


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 2.0 0.4673 2.9558 1.0442
B6(AU)-Tubtub/J m 0.5 0.4047 1.3277 0.0
B6.Cg-Ay/J f 1.3333 0.4673 2.2891 0.3776
B6.Cg-Ay/J m 2.3333 0.4673 3.2891 1.3776
B6.Cg-Lepob/J f 0.3333 0.4673 1.2891 0.0
B6.Cg-Lepob/J m 0.3333 0.4673 1.2891 0.0
BKS.Cg-Dock7m +/+ Leprdb/J f 1.0 0.4673 1.9558 0.0442
BKS.Cg-Dock7m +/+ Leprdb/J m 0.3333 0.4673 1.2891 0.0
BKSChpLt.HRS-Cpefat/J f 1.6667 0.4673 2.6224 0.7109
BKSChpLt.HRS-Cpefat/J m 1.6667 0.4673 2.6224 0.7109
C57BL/6J f 1.0 0.4673 1.9558 0.0442
C57BL/6J m 1.3333 0.4673 2.2891 0.3776
C57BLKS/J f 2.0 0.4673 2.9558 1.0442
C57BLKS/J m 1.6667 0.4673 2.6224 0.7109


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 1.25 0.3091 1.8822 0.6178
B6.Cg-Ay/J both 1.8333 0.3304 2.5092 1.1575
B6.Cg-Lepob/J both 0.3333 0.3304 1.0092 0.0
BKS.Cg-Dock7m +/+ Leprdb/J both 0.6667 0.3304 1.3425 0.0
BKSChpLt.HRS-Cpefat/J both 1.6667 0.3304 2.3425 0.9908
C57BL/6J both 1.1667 0.3304 1.8425 0.4908
C57BLKS/J both 1.8333 0.3304 2.5092 1.1575




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA