Paigen3: Diet effects on gallstone formation, liver pathology, plasma lipids, and pathogen-accelerated atherosclerosis in 8 obesity mutant mouse strains (2000)

Bouchard G, Johnson D, Carver T, Paigen B, Carey MC. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res. 2002 Jul;43(7):1105-13.   PubMed 12091495  


       
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Participants Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Guylaine Bouchard       Hopital Ste-Justine Montreal, Quebec CANADA
Martin C Carey       Harvard Medical School Boston, MA
With: Johnson D, Tovbina M, Silva A, Carver T, Tracy T, McFarland C, Archer J, Whitmore H
ContactBeverly Paigen     bev.paigen@jax.org
AffiliationJAX Heart, Lung, and Blood Center (HLB)
Part of a series: • Inbred strains   see Paigen1
• Obesity mutant strains   (this project) Paigen3
AcknowledgementsFunding provided by NIH DK51568, HL66611, DK36588, DK34854, DK52911; Medical Research Council of Canada

Generous funds from Aventis Pharmaceuticals Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersPaigen3     MPD:28
Data changelog 4 updates/corrections.       Initial release date: 02/2001.
Formatted citation
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All animals were fed a high-fat (15% fat) diet for 8 wks. Blood chemistry and cholesterol were measured. After sac, a pathology review of livers and gallbladders was conducted. A collection of liver images is available as part of this project.

Summary of procedures that were conducted
• body weight Baseline vs. high-fat diet for 8wks.
• lipid profile Cholesterol, HDL, non-HDL. 4h fast, plasma. Hepatic lipids. 8wks on high-fat diet.
• metabolic panel Alanine transaminase, bile salts (plasma) after 8wks on high-fat diet. 4h fast.
• histopathology Gallstone, gallbladder, and atherosclerosis lesion histopathology after 8wks on high-fat diet
• organ dimensions Gallbladder volume after 8wks on high-fat diet
• organ weights Liver weight after 8wks on high-fat diet.
Mice: obesity mutants   8 strains   ♀♂   age 15-19wks   1 cohort