Paigen3: Diet effects on gallstone formation, liver pathology, plasma lipids, and pathogen-accelerated atherosclerosis in 8 obesity mutant mouse strains (2000)

Bouchard G, Johnson D, Carver T, Paigen B, Carey MC. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res. 2002 Jul;43(7):1105-13.   PubMed 12091495  


         
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Ontology terms mapped to Paigen3 measures:
    MA:0000062   aorta
    MA:0000356   gall bladder
    MA:0000358   liver
    MA:0002501   plasma
    MA:0002513   bile
    MP:0000180   abnormal circulating cholesterol level
    MP:0000184   abnormal circulating HDL cholesterol level
    MP:0000598   abnormal liver morphology
    MP:0001259   abnormal body weight
    MP:0001573   abnormal circulating alanine transaminase level
    MP:0004773   abnormal bile composition
    MP:0004774   abnormal bile salt level
    MP:0004847   abnormal liver weight
    MP:0005340   altered susceptibility to atherosclerosis
    MP:0012776   abnormal liver cholesterol level
    MP:0020098   abnormal susceptibility to diet-induced aortic fatty streak lesions
    MP:0020131   abnormal gallbladder volume
    MP:0020151   abnormal circulating non-HDL cholesterol level
    VT:0000180   blood cholesterol amount
    VT:0000184   blood HDL cholesterol amount
    VT:0000272   aorta morphology trait
    VT:0000598   liver morphology trait
    VT:0000609   liver physiology trait
    VT:0001259   body mass
    VT:0001547   lipid amount
    VT:0001573   blood alanine transaminase amount
    VT:0003402   liver mass
    VT:0005084   gall bladder morphology trait
    VT:0005086   bile amount
    VT:0005675   gall bladder size trait
    VT:0010474   blood non-HDL cholesterol amount
    VT:0015078   blood homeostasis trait
Participants Beverly Paigen       The Jackson Laboratory,  Bar Harbor, ME
Guylaine Bouchard       Hopital Ste-Justine,  Montreal, Quebec CANADA
Martin C Carey       Harvard Medical School,  Boston, MA
With: Johnson D, Tovbina M, Silva A, Carver T, Tracy T, McFarland C, Archer J, Whitmore H
ContactBeverly Paigen     bev.paigen@jax.org
AffiliationJAX Heart, Lung, and Blood Center (HLB)
Part of a series: • Inbred strains   see Paigen1
• Obesity mutant strains   (this project) Paigen3
AcknowledgementsFunding provided by NIH DK51568, HL66611, DK36588, DK34854, DK52911; Medical Research Council of Canada

Generous funds from Aventis Pharmaceuticals Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersPaigen3     MPD:28
Data changelog 4 updates/corrections.       Initial release date: 02/2001.
Formatted citation
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All animals were fed a high-fat (15% fat) diet for 8 wks. Blood chemistry and cholesterol were measured. After sac, a pathology review of livers and gallbladders was conducted. A collection of liver images is available as part of this project.

Summary of procedures that were conducted
• body weight Baseline vs. high-fat diet for 8wks.
• lipid profile Cholesterol, HDL, non-HDL. 4h fast, plasma. Hepatic lipids. 8wks on high-fat diet.
• metabolic panel Alanine transaminase, bile salts (plasma) after 8wks on high-fat diet. 4h fast.
• histopathology Gallstone, gallbladder, and atherosclerosis lesion histopathology after 8wks on high-fat diet
• organ dimensions Gallbladder volume after 8wks on high-fat diet
• organ weights Liver weight after 8wks on high-fat diet.
Mice: obesity mutants   8 strains   ♀♂   age 15-19wks   1 cohort