Mrug1: Identification of polycystic kidney disease modifier candidate in cpk mutant mice (2005)

Mrug M, Li R, Cui X, Schoeb TR, Churchill GA, Guay-Woodford LM. Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse. J Am Soc Nephrol. 2005 Apr;16(4):905-16. Epub 2005 Feb 23.   PubMed 15728779  


     
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Participants M Mrug
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Li R, Cui X, Schoeb TR, Guay-Woodford LM
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by a Polycystic Kidney Disease Foundation Fellowship Award (M.M.), a Clinical Scientist Award in Translational Research from the Burroughs-Wellcome Foundation (L.M.G.-W.), and the National Institutes of Health (G.A.C.).
Project type QTL Archive data set
MPD identifiersMrug1     MPD:175
Data changelog No updates/corrections.       Initial release date: 08/2011.
The cpk mutant mouse is the most characterized model of autosomal recessive polycystic kidney disease. To identify the modifier that modulates disease severity, an intercross between B6-+/cpk (heterozygous for the Cys1cpk mutation) and CAST was generated and 461 F2 cpk homozygous mice were examined for renal phenotypes. A major contributed QTL is mapped on chromosome 4 and gene Kif12 is found in this region. This gene is proposed as a cpk modifier gene of renal disease. For detailed protocols see Mrug et al 2005.


QTL data set parameters:
Progenitor strains C57BL/6J-+/cpk     CAST/EiJ    
Cross typeF2 intercross
Population size 209 ♀     251 ♂
Notesthe sex information of 1 mouse is missing


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Mrug1 17501 histopathology (none) mean of biliary duct number   [n]  mean_BDN QTL population both 10d N=230
Mrug1 17502 histopathology (none) mean of log( biliary duct number)   [log(n)]  mean_logBDN QTL population both 1wk N=230
Mrug1 17503 histopathology (none) cholangitis severity (score 0-4, increasing severity) 0 = no/minimal inflammation, 4=severe and extensive cholangiohepatitis   [score]  Cholangitis QTL population both 10d N=230
Mrug1 17504 organ dimensions (none) kidney length   [mm]  Klength QTL population both 10d N=230
Mrug1 17505 organ dimensions (none) kidney length, square root   [sqrt(mm)]  sqrtKL QTL population both 10d N=230
Mrug1 17506 organ dimensions (none) crown to rump length of kidney   [mm]  CRLength QTL population both 10d N=230
Mrug1 17507 organ dimensions (none) kidney weight/crown to rump length  KL-CRL-Ratio QTL population both 10d N=230
Mrug1 17508 organ dimensions (none) kidney weight/crown to rump length, log transformed  logKL-CRL-Ratio QTL population both 10d N=230
Mrug1 17509 organ weights (none) kidney weight   [g]  KW QTL population both 10d N=230
Mrug1 17510 organ weights (none) kidney weight, square root   [sqrt(g)]  sqrtKW QTL population both 10d N=230
Mrug1 17511 body weight (none) mouse body weight   [g]  BodyWeight QTL population both 10d N=230
Mrug1 17512 organ weights (none) kidney weight/body weight  KW-BW-Ratio QTL population both 10d N=230
Mrug1 17513 organ weights (none) kidney weight/body weight, log transformed  logKW-BW-ratio QTL population both 10d N=230
Mrug1 17514 organ dimensions (none) kidney volume   [ml]  KVolume QTL population both 10d N=230
Mrug1 17515 organ dimensions (none) kidney volume, square root   [sqrt(ml)]  sqrtKV QTL population both 10d N=230
Mrug1 17516 organ dimensions (none) renal principal component of kidney length, weight and volume  Prin1 QTL population both 10d N=230
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Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Mpdk1   Mpdk2   Mpdk3   Mpdk4   Mpdk5   Mpdk6   Mpdk7   Mpdk8  


Project / data set:   Mrug1     a.k.a. Mrug_2005
Excel file:   Data_Description_B6xCAST_Mrug2005.xlsx
CSV file:   Mrug2005_B6xCAST_B37_Data.csv
Readme / text file:   readme_Mrug2005.txt
QC plots, figures, etc.:   QCReport_Mrug2005.pdf