Mrug1: Identification of polycystic kidney disease modifier candidate in cpk mutant mice (2005)

Mrug M, Li R, Cui X, Schoeb TR, Churchill GA, Guay-Woodford LM. Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse. J Am Soc Nephrol. 2005 Apr;16(4):905-16. Epub 2005 Feb 23.   PubMed 15728779  

Mrug1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Investigators M Mrug
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Li R, Cui X, Schoeb TR, Guay-Woodford LM
ContactGary A Churchill
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by a Polycystic Kidney Disease Foundation Fellowship Award (M.M.), a Clinical Scientist Award in Translational Research from the Burroughs-Wellcome Foundation (L.M.G.-W.), and the National Institutes of Health (G.A.C.).
Project type QTL Archive data set
MPD identifiersMrug1     MPD:175
Data changelog No updates/corrections.       Initial release date: 08/2011.
The cpk mutant mouse is the most characterized model of autosomal recessive polycystic kidney disease. To identify the modifier that modulates disease severity, an intercross between B6-+/cpk (heterozygous for the Cys1cpk mutation) and CAST was generated and 461 F2 cpk homozygous mice were examined for renal phenotypes. A major contributed QTL is mapped on chromosome 4 and gene Kif12 is found in this region. This gene is proposed as a cpk modifier gene of renal disease. For detailed protocols see Mrug et al 2005.

QTL data set parameters:
Progenitor strains C57BL/6J-+/cpk     CAST/EiJ    
Cross typeF2 intercross
Population size 209 ♀     251 ♂
Notesthe sex information of 1 mouse is missing

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Mpdk1   Mpdk2   Mpdk3   Mpdk4   Mpdk5   Mpdk6   Mpdk7   Mpdk8  

Project / data set:   Mrug1     a.k.a. Mrug_2005
Excel file:   Data_Description_B6xCAST_Mrug2005.xlsx
CSV file:   Mrug2005_B6xCAST_B37_Data.csv
Readme / text file:   readme_Mrug2005.txt
QC plots, figures, etc.:   QCReport_Mrug2005.pdf