Brockmann1: Genetic factors of body, muscle, fat weight and their pleiotropic effects in F2 progeny from 2 intercross populations (2009)

Brockmann GA, Tsaih SW, Neuschl C, Churchill GA, Li R. Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both. Physiol Genomics. 2009 Jan 8;36(2):114-26. Epub 2008 Nov 4.   PubMed 18984673     FullText


       
Brockmann1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Ontology terms mapped to Brockmann1 measures:
    MA:0000059   blood
    MA:0000141   spleen
    MA:0000326   reproductive system
    MA:0000358   liver
    MA:0000368   kidney
    MA:0000472   abdominal fat pad
    MA:0002363   quadriceps
    MA:0002501   plasma
    MA:0002502   serum
    MP:0000010   abnormal abdominal fat pad morphology
    MP:0000180   abnormal circulating cholesterol level
    MP:0000184   abnormal circulating HDL cholesterol level
    MP:0001259   abnormal body weight
    MP:0001560   abnormal circulating insulin level
    MP:0001933   abnormal litter size
    MP:0002707   abnormal kidney weight
    MP:0004700   abnormal circulating insulin-like growth factor I level
    MP:0004847   abnormal liver weight
    MP:0004951   abnormal spleen weight
    MP:0005667   abnormal circulating leptin level
    MP:0011969   abnormal circulating triglyceride level
    MP:0020164   abnormal quadriceps weight
    VT:0000010   abdominal fat pad morphology trait
    VT:0000180   blood cholesterol amount
    VT:0000184   blood HDL cholesterol amount
    VT:0001259   body mass
    VT:0001560   blood insulin amount
    VT:0001923   female fertility trait
    VT:0002161   female fecundity trait
    VT:0002644   blood triglyceride amount
    VT:0002707   kidney mass
    VT:0003402   liver mass
    VT:0004951   spleen mass
    VT:0005667   blood leptin amount
    VT:0010479   blood insulin-like growth factor amount
    VT:0010569   quadriceps morphology trait
    VT:1000189   offspring quantity
Participants G A Brockmann
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
With: Tsaih SW, Neuschl C, Li R
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThe project was supported from the Federal Ministry for Education and Research, Germany (NGFN project 01GS0486, G. A. Brockmann),Deutsche Forschungsgemeinschaft (GRK 1208, C. Neuschl), and National Institute of General Medical Sciences (GM-076468, G. A. Churchill).
Project type QTL Archive data set
MPD identifiersBrockmann1     MPD:213
Data changelog No updates/corrections.       Initial release date: 09/2010.
This project is to investigate the relationships between genetic loci and different phenotypes influencing body weight. Two F2 populations were generated: Cross 1 is an intercross of DBA/2 and NMRI8; Cross 2 is an intercross of DBA/2 and DU6i. For both crosses the F2 progeny were fed breeding diet (1) and phenotyped for body weight, muscle weight, fat weight and other related phenotypes (studied phenotypes vary in cross1 vs. cross2). For detailed protocols see Brockmann et al 2009.

(1) Breeding diet: containing 12.5 MJ/kg metabolic energy with an average content of 22.5% crude protein, 5.0% crude fat, 4.5% crude fiber, 6.5% crude ash, 13.5% water, 48.0% N-free extract, vitamins, trace elements, amino acids, and minerals (Altromin diet 1314).


QTL data set parameters:
Cross 1: DBA/2 x NMRI8       Brockmann1
Progenitor strains DBA/2J     NMRI8    
Cross direction notation(DBA/2 x NMRI8) F1 x (DBA/2 x NMRI8) F1
Cross typeF2 intercross
Population size 142 ♀     133 ♂

Cross 2: DBA/2 x DU6i       Brockmann1b
Progenitor strains DBA/2J     DU6i    
Cross direction notation(DBA/2 x DU6i) F1 x (DBA/2 x DU6i) F1
Cross typeF2 intercross
Population size 174 ♀     228 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.



Cross 1: DBA/2 x NMRI8     Brockmann1     a.k.a. Brockmann_2009a
Excel file:   Data_Description_DBA2xNMRI8_Brockmann2009.xlsx
CSV file:   Brockmann2009_DBA2xNMRI8_B37_Data.csv
Readme / text file:   readme_Brockmann2009a.txt
QC plots, figures, etc.:   QCReport_Brockmann2009a.pdf

Cross 2: DBA/2 x DU6i     Brockmann1b     a.k.a. Brockmann_2009b
Excel file:   Data_Description_DBA2xDU6i_Brockmann2009.xlsx
CSV file:   Brockmann2009_DBA2xDU6i_B37_Data.csv
Readme / text file:   readme_Brockmann2009b.txt
QC plots, figures, etc.:   QCReport_Brockmann2009b.pdf