Brockmann1: Genetic factors of body, muscle, fat weight and their pleiotropic effects in F2 progeny from 2 intercross populations (2009)
Brockmann GA, Tsaih SW, Neuschl C, Churchill GA, Li R. Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both.
Physiol Genomics. 2009 Jan 8;36(2):114-26. Epub 2008 Nov 4.
This project is to investigate the relationships between genetic loci and different phenotypes influencing body weight. Two F2 populations were generated:
Cross 1 is an intercross of DBA/2 and NMRI8;
Cross 2 is an intercross of DBA/2 and DU6i. For both crosses
the F2 progeny were fed breeding diet (1) and phenotyped for body weight, muscle weight, fat weight and other related phenotypes (studied phenotypes vary in cross1 vs. cross2). For detailed protocols see Brockmann et al 2009.
(1) Breeding diet: containing 12.5 MJ/kg metabolic energy with an average content of 22.5% crude protein, 5.0% crude fat, 4.5% crude fiber, 6.5% crude ash, 13.5% water, 48.0% N-free extract, vitamins, trace elements, amino acids, and minerals (Altromin diet 1314).
Note on studied population: DBA2J x NMRI8 and DBA2J x DU6i intercrosses
Procedures conducted:
(1) Breeding diet: containing 12.5 MJ/kg metabolic energy with an average content of 22.5% crude protein, 5.0% crude fat, 4.5% crude fiber, 6.5% crude ash, 13.5% water, 48.0% N-free extract, vitamins, trace elements, amino acids, and minerals (Altromin diet 1314).
Note on studied population: DBA2J x NMRI8 and DBA2J x DU6i intercrosses
Procedures conducted:
| Body, organ weights, litter size, abdominal fat, lipids, insulin, leptin. |
Brockmann1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Ontology terms mapped to Brockmann1 measures:
| Investigators |
G A Brockmann Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
| Participants | Tsaih SW, Neuschl C, Li R |
| Contact | Gary A Churchill gary.churchill@jax.org |
| Affiliated Center | QTL Archive |
| Acknowledgements | The project was supported from the Federal Ministry for Education and Research, Germany (NGFN project 01GS0486, G. A. Brockmann),Deutsche Forschungsgemeinschaft (GRK 1208, C. Neuschl), and National Institute of General Medical Sciences (GM-076468, G. A. Churchill). |
| QTL Archive data set | |
| MPD identifiers | Brockmann1 MPD:213 |
| No updates/corrections. Initial release date: 09/2010. |
Cross 1: DBA/2 x NMRI8 Brockmann1 a.k.a. Brockmann_2009a
Excel file: Data_Description_DBA2xNMRI8_Brockmann2009.xlsx
CSV file: Brockmann2009_DBA2xNMRI8_B37_Data.csv
Readme / text file: ._readme.txt
Readme / text file: readme_Brockmann2009a.txt
QC plots, figures, etc.: QCReport_Brockmann2009a.pdf
Project / data set: Brockmann1b a.k.a. None