Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5.
Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.
Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6.
David W Threadgill Texas A&M University, College Station, TX|
Alison Harrill University of Arkansas for Medical Sciences, Little Rock, AR
Ivan Rusyn Texas A&M University, College Station, TX
|Contact||David W Threadgill firstname.lastname@example.org
|Part of a series:||
(this project) Threadgill1
• Phase 2 see Threadgill2
|Acknowledgements||Funding provided by NIH ES07126, ES11391, ES10126, GM38149, RR00046, ES35513, ES25497, ES65406; US Environmental Protection Agency STAR-RD832720
For technical assistance and histology: Balletta L, Bradford B, Lodestro C, Lee D, Maki A, Kosyk O, Woods C, Clore E, Hodges N, Boorman G. For serum enzyme testing: Kim H and the Clinical Chemistry Core Facility (UNC).
|Phenotype strain survey data set|
|MPD identifiers||Threadgill1 MPD:194|
|1 update/correction. Initial release date: 02/2009.|
Click above to copy-paste the entire citation for this MPD web page.
|Summary of procedures that were conducted|
|• metabolic panel||Blood urea nitrogen, alanine transaminase, aspartate transaminase (serum), liver enzyme homeostasis. Acetaminophen (several doses) vs. control, several timepoints post-Rx. 18h fast.|
|• histopathology||Liver histopathology, necrosis after acetaminophen vs. control. 18h fast.|
|• metabolite quantification||Liver protein homeostasis. Acetaminophen vs. control. 18h fast.|
|• biomarker quantification||Liver cytochrome isoforms. Acetaminophen vs. control. 18h fast.|
|• organ weights||Liver weight after acetaminophen (several doses) vs. control. 18h fast.|