Wittenburg2: Cholesterol gallstone formation in reciprocal backcrosses between PERA/EiJ and I/LnJ (2003)

References   (chronological)

1.   Wittenburg H, Lyons MA, Li R, Churchill GA, Carey MC, Paigen B. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology. 2003 Sep;125(3):868-81.   PubMed 12949731  

2.   Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA. Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping. Genetics. 2005 Mar;169(3):1699-709. Epub 2005 Jan 16.   PubMed 15654110     FullText

3.   Wittenburg H, Lyons MA, Li R, Kurtz U, Wang X, Mössner J, Churchill GA, Carey MC, Paigen B. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006 Aug;47(8):1780-90. Epub 2006 May 9.   PubMed 16685081  

Wittenburg2 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Investigators H Wittenberg
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Lyons MA, Li R, Carey MC, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsFunding provided by NIH DK51568, DK36588, DK52911, DK34854, CA34196, DK73687, GM070683, HL55001; Deutsche Forschungsgemeinschaft, American Physiological Society, and the American Liver Foundation, the National Health and Medical Research Council of Australia, the Gastroenterological Society of Australia.
Project type QTL Archive data set
MPD identifiersWittenburg2     MPD:138
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross of PERA/EiJ and I/LnJ was generated to identify cholesterol gallstone susceptibility loci. F2 progeny of both sexes were administered a high-fat (15%) diet for 8 wks and examined for gallstone formation and related phenotypes. Gallstones were characterized qualitatively and quantitatively, and lipid profiles determined for plasma samples. Mice were fasted prior to sample collection. For detailed protocols see Wittenburg et al 2003.

QTL data set parameters:
Progenitor strains I/LnJ     PERA/EiJ    
Cross typeF2 intercross
Population size 164 ♀     141 ♂

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Hdlq10   Hdlq33   Hdlq34   Hdlq35   Hdlq36   Hdlq37   Hdlq38   Hdlq39   Lith7   Lith8   Lith9   Nhdlq10   Nhdlq8   Nhdlq9  

Project / data set:   Wittenburg2     a.k.a. Wittenburg_2003
Excel file:   Data_Description_PERAxI_Wittenburg2003.xlsx
CSV file:   Wittenburg2003_PERAxI_B37_Data.csv
Readme / text file:   readme_Wittenburg2003.txt