Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5.
Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.
Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6.
David W Threadgill Texas A&M University, College Station, TX|
Alison Harrill University of Arkansas for Medical Sciences, Little Rock, AR
With: Ross PK, Rusyn I
|Contact||David W Threadgill firstname.lastname@example.org
|Part of a series:||
• Phase 2 (this project) Threadgill2
|Acknowledgements||Funding provided by NIH ES07126, ES11391, ES10126, GM38149, RR00046, ES35513, ES25497, ES65406; US Environmental Protection Agency STAR-RD832720
For technical assistance and histology: Balletta L, Bradford B, Lodestro C, Lee D, Maki A, Kosyk O, Woods C, Clore E, Hodges N, Boorman G. For serum enzyme testing: Kim H and the Clinical Chemistry Core Facility (UNC).
|Phenotype strain survey data set|
|MPD identifiers||Threadgill2 MPD:396|
|No updates/corrections. Initial release date: 03/2012.|
Click above to copy-paste the entire citation for this MPD web page.
|Summary of procedures that were conducted|
|• metabolic panel||Alanine transaminase (serum). Acetaminophen (several doses) vs. control.|
|• metabolite quantification||Glutathione.|
|• drug and metabolite quantification||Acetaminophen metabolite concentrations (serum) and liver protein homeostasis. Baseline vs. acetaminophen (several doses, several timepoints).|
|• histopathology||Liver histopathology, necrosis, injury after acetaminophen vs. control. 18h fast.|