Wittenburg H, Lammert F, Wang DQ, Churchill GA, Li R, Bouchard G, Carey MC, Paigen B. Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice.
Physiol Genomics. 2002 Feb 11;8(1):67-77.
Liver weight, gallbladder and gallstone histopathology. |
Investigators |
H Wittenberg Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
Participants | Lammert F, Wang DQ, Li R, Bouchard G, Carey MC, Paigen B |
Contact | Gary A Churchill gary.churchill@jax.org |
Affiliated Center | QTL Archive |
Acknowledgements | Grant: This work was supported in part by National Institute of Diabetes and Digestive and Kidney Diseases Grants DK-51568 (to B. Paigen), DK-36588, DK-52911, and DK-34854 (to M. C. Carey), DK-54012 (to D. Q.-H. Wang), and by a grant from the Ellison Medical Foundation (to D. Q.-H. Wang). F. Lammert (La 997/3-1) and H. Wittenburg (WI 1905/1-1) were supported by the Deutsche Forschungsgemeinschaft. |
QTL Archive data set | |
MPD identifiers | Wittenburg1 MPD:126 |
No updates/corrections. Initial release date: 01/2008. |
Data set |
Procedure / Protocol |
Treatment |
Phenotype Measure / Variable (click to view) |
Panel |
No. of Strains |
Sex |
Age |
Sample Size (Avg)
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body weight | high-fat diet | body weight, log transformed [log(g)] bw_log 12601 | QTL population | both | N=130 | |||||||
organ weights | high-fat diet | liver weight [g] liver_wt 12602 | QTL population | both | N=130 | |||||||
organ weights | high-fat diet | liver-to-bw ratio [ratio] liver_bw_ratio 12603 | QTL population | both | N=130 | |||||||
organ dimensions | high-fat diet | gallbladder, volume [µL] gallbladder_vol 12604 | QTL population | both | N=130 | |||||||
histopathology | high-fat diet | gallbladder, mucin (score 0-4), log transformed [score] gallbladder_mucin_log 12605 | QTL population | both | N=130 | |||||||
histopathology | high-fat diet | gallstones, presence (score 0=absent, 1=present) [score] gallstone_presence 12606 | QTL population | both | N=130 | |||||||
histopathology | high-fat diet | gallstones, number [n] gallstone_count 12607 | QTL population | both | N=130 | |||||||
histopathology | high-fat diet | weight of solid gallstones [mg] gallstone_wt 12608 | QTL population | both | N=130 | |||||||
histopathology | high-fat diet | gallstone severity (score 0=absent, 1=crystals, 2=stones) [score] gallstone_score 12609 | QTL population | both | N=130 | |||||||
histopathology | high-fat diet | gallstones volume gallstone_vol 12610 | QTL population | both | N=130 | |||||||