Wittenburg1: Cholesterol gallstones, gallbladder mucin accumulation, and related gallstone phenotypes in reciprocal backcrosses between AKR/J and SWR/J (2002)

Wittenburg H, Lammert F, Wang DQ, Churchill GA, Li R, Bouchard G, Carey MC, Paigen B. Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice. Physiol Genomics. 2002 Feb 11;8(1):67-77.   PubMed 11842132  


       
A reciprocal backcross of AKR/J and SWR/J was generated to identify QTLs for cholesterol gallstones, gallbladder mucin accumulation, liver and body weight. At 8 wks of age, backcross progeny of both sexes were administered a high-fat (15%) diet for 12 wks and examined for gallstone formation and related phenotypes. Mice were fasted prior to sample collection. For detailed protocols see Wittenburg et al 2002.

Note on studied population: AKR/J and SWR/J reciprocal backcrosses

Procedures conducted:
• study archive  Liver weight, gallbladder and gallstone histopathology.

Wittenburg1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators H Wittenberg
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Lammert F, Wang DQ, Li R, Bouchard G, Carey MC, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsGrant: This work was supported in part by National Institute of Diabetes and Digestive and Kidney Diseases Grants DK-51568 (to B. Paigen), DK-36588, DK-52911, and DK-34854 (to M. C. Carey), DK-54012 (to D. Q.-H. Wang), and by a grant from the Ellison Medical Foundation (to D. Q.-H. Wang). F. Lammert (La 997/3-1) and H. Wittenburg (WI 1905/1-1) were supported by the Deutsche Forschungsgemeinschaft.
Project type QTL Archive data set
MPD identifiersWittenburg1     MPD:126
Data changelog No updates/corrections.       Initial release date: 01/2008.
QTL data set parameters:
Progenitor strains AKR/J     SWR/J    
Cross direction notation(SWR x AKR) x AKR; AKR x (SWR x AKR)
Cross typeReciprocal backcross
Population size 41 ♀     220 ♂
Age18-20wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Lith1   Lith2   Lith3   Lith4   Lith5  


Project / data set:   Wittenburg1     a.k.a. Wittenburg_2002
Excel file:   Data_Description_SWRxAKR_BC_Wittenburg2002.xlsx
CSV file:   Wittenburg2002_SWRxAKR_BC_B37_Data.csv
Readme / text file:   readme_Wittenburg2002.txt