Project measure / variable:   Paigen3   liverweight

ID, description, units MPD:2807   liverweight   liver weight at sacrifice   [g]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure organ weights
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - liver weight at sacrifice



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means2.53   g 2.85   g
Median of the strain means1.90   g 2.31   g
SD of the strain means± 1.34 ± 1.23
Coefficient of variation (CV)0.532 0.432
Min–max range of strain means1.49   –   4.96   g 1.70   –   4.83   g
Mean sample size per strain20.6   mice 20.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 3.4995 3.4995 14.874 0.0001
strain 6 363.081 60.5135 257.2029 < 0.0001
sex:strain 6 6.1426 1.0238 4.3514 0.0003
Residuals 275 64.7007 0.2353


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 1.76 0.288   24 0.0588 0.164 1.14, 2.4 -0.57
B6(AU)-Tubtub/J m 2.51 0.415   26 0.0814 0.165 1.67, 3.12 -0.28
B6.BKS(D)-Leprdb/J m 4.14 0.903   16 0.226 0.218 2.52, 5.25 1.05
B6.Cg-Ay/J f 1.9 0.186   23 0.0387 0.0976 1.56, 2.28 -0.47
B6.Cg-Ay/J m 1.92 0.27   34 0.0463 0.141 1.37, 2.48 -0.76
B6.Cg-Lepob/J f 4.96 0.6   17 0.146 0.121 4.02, 6.1 1.81
B6.Cg-Lepob/J m 4.83 0.856   20 0.191 0.177 2.86, 6.31 1.61
BKS.Cg-Dock7m +/+ Leprdb/J f 3.86 0.746   18 0.176 0.193 2.25, 4.88 0.99
BKS.Cg-Dock7m +/+ Leprdb/J m 3.85 0.979   15 0.253 0.254 2.25, 5.34 0.81
BKSChpLt.HRS-Cpefat/J f 2.18 0.397   16 0.0991 0.182 1.69, 2.93 -0.26
BKSChpLt.HRS-Cpefat/J m 2.11 0.423   18 0.0996 0.201 1.47, 2.84 -0.6
C57BL/6J f 1.54 0.157   19 0.036 0.102 1.29, 1.89 -0.73
C57BL/6J m 1.76 0.291   16 0.0728 0.165 1.32, 2.18 -0.89
C57BLKS/J f 1.49 0.295   27 0.0569 0.199 1.05, 2.11 -0.77
C57BLKS/J m 1.7 0.476   16 0.119 0.279 1.28, 3.03 -0.94


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 1.7571 0.099 1.952 1.5622
B6(AU)-Tubtub/J m 2.5077 0.0951 2.695 2.3204
B6.Cg-Ay/J f 1.903 0.1011 2.1022 1.7039
B6.Cg-Ay/J m 1.9209 0.0832 2.0846 1.7571
B6.Cg-Lepob/J f 4.9565 0.1176 5.1881 4.7249
B6.Cg-Lepob/J m 4.8265 0.1085 5.04 4.613
BKS.Cg-Dock7m +/+ Leprdb/J f 3.8561 0.1143 4.0812 3.631
BKS.Cg-Dock7m +/+ Leprdb/J m 3.8513 0.1252 4.0979 3.6048
BKSChpLt.HRS-Cpefat/J f 2.1788 0.1213 2.4175 1.94
BKSChpLt.HRS-Cpefat/J m 2.1067 0.1143 2.3317 1.8816
C57BL/6J f 1.54 0.1113 1.7591 1.3209
C57BL/6J m 1.7619 0.1213 2.0006 1.5232
C57BLKS/J f 1.4867 0.0933 1.6704 1.3029
C57BLKS/J m 1.7031 0.1213 1.9418 1.4644


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 2.1324 0.0687 2.2675 1.9972
B6.Cg-Ay/J both 1.912 0.0655 2.0409 1.7831
B6.Cg-Lepob/J both 4.8915 0.08 5.049 4.734
BKS.Cg-Dock7m +/+ Leprdb/J both 3.8537 0.0848 4.0206 3.6868
BKSChpLt.HRS-Cpefat/J both 2.1427 0.0833 2.3068 1.9787
C57BL/6J both 1.6509 0.0823 1.8129 1.4889
C57BLKS/J both 1.5949 0.0765 1.7455 1.4443




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA