Rusyn6: Trichloroethylene metabolism and tissue-specific toxicity in males of 7 inbred strains of mice (2014)

Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J Toxicol Environ Health A. 2015;78(1):15-3doi: 10.1080/15287394.2015.958417.   PubMed 25424544     FullText

Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78(1):32-49. doi: 10.1080/15287394.2015.958418.   PubMed 25424545     FullText


         
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Participants Ivan Rusyn       Texas A&M University,  College Station, TX
With: Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A
ContactIvan Rusyn     IRusyn@cvm.tamu.edu     Lab web site
AcknowledgementsFunding provided by NIH ES005948, ES010126; AstraZeneca
Project type Phenotype strain survey data set
MPD identifiersRusyn6     MPD:512
Data changelog No updates/corrections.       Initial release date: 06/2014.
Formatted citation
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A population-based approach was used to test the hypothesis that trichloroethylene (TCE) induced toxicity is associated with the formation of oxidative TCE metabolites. Liver, kidney and serum samples were tested. Major metabolizing enzymes responsible for oxidative biotransformation of TCE, as well as markers of liver and kidney cell proliferation and kidney damage were examined.

Summary of procedures that were conducted
• organ weights Liver, kidney weights. Trichloroethylene-exposed vs. control.
• metabolic panel Blood urea nitrogen (serum). Trichloroethylene-exposed vs. control.
• drug and metabolite quantification Trichloroethylene metabolite in blood, liver, kidney after trichloroethylene exposure.
• RNA expression profiling Trichloroethylene effect on mRNA gene expression in liver and kidney, relative to controls.
• histopathology Kidney histopathology evaluation after trichloroethylene exposure, relative to controls.
Mice: inbred   7 strains   ♂   age 6-7wks   2 cohorts