GMC11: Glucose tolerance test in 6 inbred founder strains of the Collaborative Cross (2020)

German Mouse Clinic and Department of Infection Genetics, HZI   GMC Management Team   With: Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Rathkolb B, Wolf E, Lengger C, Kollmus H, Schughart K

          List all GMC measures
GMC11 downloads
• Download GMC11 project data set     one row per animal, one column per trait
• Download GMC11 strain means, SD, N, etc.     one row per strain/sex/measure
Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Rathkolb B, Wolf E, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC11     MPD:560
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
The glucose tolerance test (GTT) measures the clearance of an intraperitoneally-injected glucose load from the body. It is used to detect disturbances in glucose metabolism that can be linked to human conditions such as diabetes or metabolic syndrome. Animals are fasted for approximately 16 h, fasted blood glucose levels are determined before a solution of glucose is administered by intraperitoneal injection. Subsequently, the blood glucose level is measured at different time points post-injection during the following two hours.

Summary of procedures that were conducted
• glucose tolerance 0 to 120 min after 20% glucose i.p., 16h fast.
Mice: inbred w/CC8   6 strains   ♀♂   age 13-14wks   5 experimental groups