Brinkmeyer1: Susceptibility to Theiler's murine encephalomyelitis virus in 5 Collaborative Cross strains of mice (2017)

Brinkmeyer-Langford CL, Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ, Threadgill DW. Host genetic background influences diverse neurological responses to viral infection in mice. Sci Rep. 2017 Sep 22;7(1):12194. doi: 10.1038/s41598-017-12477-2.   PubMed 28939838     FullText

Brinkmeyer1 downloads
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• Download Brinkmeyer1 animal data matrix     with factor-related expansion applied as necessary
• Download Brinkmeyer1 strain means, SD, N, etc.     one row per strain/sex/measure
• Brinkmeyer1 supplementary data
Investigators Candice L Brinkmeyer-Langford       Texas A&M University,  College Station, TX
David W Threadgill       Texas A&M University,  College Station, TX
Participants Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ
ContactCandice L Brinkmeyer-Langford     Lab web site
Project type Phenotype strain survey data set
MPD identifiersBrinkmeyer1     MPD:644
Data changelog No updates/corrections.       Initial release date: 04/2019.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
This study assessed the phenotypic consequences of TMEV infection in 5 CC strains of mice. Outcomes of long-term infection (3 mo) and acute vs. early chronic infection (7 vs. 28 d post infection) were evaluated using neurological and behavioral phenotyping tests along with body weight and clinical scores. Data for mock infected mice are in a supplemental data download file.

Experimental groups in this study:
• None     • None    

Procedures conducted:
• body weight 
• health assessment  Clinical health assessment scores, TMEV infection.
• RNA expression profiling  TMEV transcript abundance.
• open field test  Locomotor activity, TMEV infection.
• gait analysis  DigiGait analysis and footprint analysis, TMEV infection.
• rotarod  Latency to fall from accelerating rotarod, TMEV infection.

Mice: CC   5 strains   ♀♂   age 4wks   2 experimental groups