MPD: Data set: Brinkmeyer1

Brinkmeyer1: Susceptibility to Theiler's murine encephalomyelitis virus in 5 Collaborative Cross strains of mice (2017)

Brinkmeyer-Langford CL, Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ, Threadgill DW. Host genetic background influences diverse neurological responses to viral infection in mice. Sci Rep. 2017 Sep 22;7(1):12194. doi: 10.1038/s41598-017-12477-2. PubMed 28939838 FullText

This study assessed the phenotypic consequences of TMEV infection in 5 CC strains of mice. Outcomes of long-term infection (3 mo) and acute vs. early chronic infection (7 vs. 28 d post infection) were evaluated using neurological and behavioral phenotyping tests along with body weight and clinical scores. Data for mock infected mice are in a supplemental data download file.

Experimental groups in this study:
• None • None

Procedures conducted:

• body weight
• health assessment		Clinical health assessment scores, TMEV infection.
• RNA expression profiling		TMEV transcript abundance.
• open field test		Locomotor activity, TMEV infection.
• gait analysis		DigiGait analysis and footprint analysis, TMEV infection.
• rotarod		Latency to fall from accelerating rotarod, TMEV infection.

Brinkmeyer1 downloads
• Download Brinkmeyer1 project data set animal data, as uploaded
• Download Brinkmeyer1 animal data matrix with factor-related expansion applied as necessary
• Download Brinkmeyer1 strain means, SD, N, etc. one row per strain/sex/measure
• Brinkmeyer1 supplementary data

Ontology terms mapped to Brinkmeyer1 measures:

MA:0000007 limb
MA:0000025 forelimb
MA:0000026 hindlimb
MA:0000168 brain
MP:0001259 abnormal body weight
MP:0001392 abnormal locomotor behavior
MP:0001406 abnormal gait
MP:0001440 abnormal grooming behavior
MP:0001516 abnormal motor coordination/balance
MP:0020185 altered susceptibility to viral infection
VT:0001259 body mass
VT:0001392 locomotor behavior trait
VT:0001440 grooming behavior trait
VT:0001516 motor coordination/balance trait
VT:0010439 response to viral infection trait
VT:0010731 gait trait

Investigators	Candice L Brinkmeyer-Langford Texas A&M University, College Station, TX David W Threadgill Texas A&M University, College Station, TX
Participants	Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ
Contact	Candice L Brinkmeyer-Langford Brinkmeyer@tamu.edu Lab web site
Project type	Phenotype strain survey data set
MPD identifiers	Brinkmeyer1 MPD:644
Data changelog	No updates/corrections. Initial release date: 04/2019.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Mice: CC 5 strains ♀♂ age 4wks 2 experimental groups

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)

Brinkmeyer1:1	Brinkmeyer1	body weight	Theiler's murine encephalomyelitis virus	body weight, post infection [g] bw 64401 day 0 day 2 day 4 day 6 day 8 day 10 day 14 day 17 day 22 day 27 (6 more)...	CC	5	both	4wks	N=5

Brinkmeyer1:17	Brinkmeyer1	health assessment	Theiler's murine encephalomyelitis virus	clinical score (0=normal, 6=moribund), post infection [score] clin_score 64417 day 0 day 2 day 4 day 6 day 8 day 12 day 18 day 24 day 29 day 34 (6 more)...	CC	5	both	4wks	N=5

Brinkmeyer1:33	Brinkmeyer1	RNA expression profiling	Theiler's murine encephalomyelitis virus	TMEV transcript abundance (normalized), post infection TMEV 64433 day 7 day 28	CC	4	both	4wks	N=1

Brinkmeyer1:35	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of seconds spent grooming, 10 min test, post infection wk 3 (manual assessment) [s] grooming 64435	CC	5	both	4wks	N=2

Brinkmeyer1:36	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of times mouse reared, 10 min test, post infection wk 3 (manual assessment) [n] activity_rearing 64436	CC	5	both	4wks	N=2

Brinkmeyer1:37	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	horizontal movement latency, 30 min test, post infection wk 3 [s] horiz_latency 64437 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:39	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of horizontal movements (beam breaks), 30 min test, post infection wk 3 [n] horiz_activity 64439 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:41	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	horizontal distance traveled, 30 min test, post infection wk 3 [cm] horiz_distance 64441 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:43	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent moving horizontally, 30 min test, post infection wk 3 [s] horiz_time 64443 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:45	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	horizontal movement velocity, 30 min test, post infection wk 3 [cm/s] horiz_velocity 64445 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:47	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of vertical plane entries, 30 min test, post infection wk 3 [n] vert_activity 64447 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:49	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of vertical plane episodes, 30 min test, post infection wk 3 [n] vert_episodes 64449 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:51	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent vertical, 30 min test, post infection wk 3 [s] vert_time 64451 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:53	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent resting, 30 min test, post infection wk 3 [s] resting 64453 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:55	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of center entries, 30 min test, post infection wk 3 [n] center_entries 64455 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:57	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent in center, 30 min test, post infection wk 3 [s] center_time 64457 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:59	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent in periphery, 30 min test, post infection wk 3 [s] periphery_time 64459 trial 1 trial 2	CC	4	both	4wks	N=2

Brinkmeyer1:61	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of steps included in analysis as measured by DigiGait, post infection day 27, forelimb [n] num_steps_fore 64461 left right	CC	4	both	4wks	N=1

Brinkmeyer1:63	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of steps included in analysis as measured by DigiGait, post infection day 27, hindlimb [n] num_steps_hind 64463 left right	CC	4	both	4wks	N=1

Brinkmeyer1:65	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of swing phase (no paw contact with belt) as measured by DigiGait, post infection day 27, forelimb [s] swing_dur_fore 64465 left right	CC	4	both	4wks	N=1

Brinkmeyer1:67	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of swing phase (no paw contact with belt) as measured by DigiGait, post infection day 27, hindlimb [s] swing_dur_hind 64467 left right	CC	4	both	4wks	N=1

Brinkmeyer1:69	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in air as measured by DigiGait, post infection day 27, forelimb [%] swing_stride_fore 64469 left right	CC	4	both	4wks	N=1

Brinkmeyer1:71	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in air as measured by DigiGait, post infection day 27, hindlimb [%] swing_stride_hind 64471 left right	CC	4	both	4wks	N=1

Brinkmeyer1:73	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of braking phase as measured by DigiGait, post infection day 27, forelimb [s] brake_dur_fore 64473 left right	CC	4	both	4wks	N=1

Brinkmeyer1:75	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of braking phase as measured by DigiGait, post infection day 27, hindlimb [s] brake_dur_hind 64475 left right	CC	4	both	4wks	N=1

Brinkmeyer1:77	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in braking phase as measured by DigiGait, post infection day 27, forelimb [%] brake_stride_fore 64477 left right	CC	4	both	4wks	N=1

Brinkmeyer1:79	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in braking phase as measured by DigiGait, post infection day 27, hindlimb [%] brake_stride_hind 64479 left right	CC	4	both	4wks	N=1

Brinkmeyer1:81	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in braking phase as measured by DigiGait, post infection day 27, forelimb [%] brake_stance_fore 64481 left right	CC	4	both	4wks	N=1

Brinkmeyer1:83	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in braking phase as measured by DigiGait, post infection day 27, hindlimb [%] brake_stance_hind 64483 left right	CC	4	both	4wks	N=1

Brinkmeyer1:85	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of propulsion phase as measured by DigiGait, post infection day 27, forelimb [s] propel_dur_fore 64485 left right	CC	4	both	4wks	N=1

Brinkmeyer1:87	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of propulsion phase as measured by DigiGait, post infection day 27, hindlimb [s] propel_dur_hind 64487 left right	CC	4	both	4wks	N=1

Brinkmeyer1:89	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in propulsion phase as measured by DigiGait, post infection day 27, forelimb [%] propel_stride_fore 64489 left right	CC	4	both	4wks	N=1

Brinkmeyer1:91	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in propulsion phase as measured by DigiGait, post infection day 27, hindlimb [%] propel_stride_hind 64491 left right	CC	4	both	4wks	N=1

Brinkmeyer1:93	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in propulsion phase as measured by DigiGait, post infection day 27, forelimb [%] propel_stance_fore 64493 left right	CC	4	both	4wks	N=1

Brinkmeyer1:95	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in propulsion phase as measured by DigiGait, post infection day 27, hindlimb [%] propel_stance_hind 64495 left right	CC	4	both	4wks	N=1

Brinkmeyer1:97	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in any contact with treadmill belt as measured by DigiGait, post infection day 27, forelimb [%] stance_stride_fore 64497 left right	CC	4	both	4wks	N=1

Brinkmeyer1:99	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in any contact with treadmill belt as measured by DigiGait, post infection day 27, hindlimb [%] stance_stride_hind 64499 left right	CC	4	both	4wks	N=1

Brinkmeyer1:101	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of swing phase time to stance phase time as measured by DigiGait, post infection day 27, forelimb [ratio] stance_swing_fore 64501 left right	CC	4	both	4wks	N=1

Brinkmeyer1:103	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of swing phase time to stance phase time as measured by DigiGait, post infection day 27, hindlimb [ratio] stance_swing_hind 64503 left right	CC	4	both	4wks	N=1

Brinkmeyer1:105	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of one complete stride for one paw (equal to stance and swing durations) as measured by DigiGait, post infection day 27, forelimb [s] stride_dur_fore 64505 left right	CC	4	both	4wks	N=1

Brinkmeyer1:107	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of one complete stride for one paw (equal to stance and swing durations) as measured by DigiGait, post infection day 27, hindlimb [s] stride_dur_hind 64507 left right	CC	4	both	4wks	N=1

Brinkmeyer1:109	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of times each second (cadence) that a paw takes a complete stride as measured by DigiGait, post infection day 27, forelimb [n/s] stride_freq_fore 64509 left right	CC	4	both	4wks	N=1

Brinkmeyer1:111	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of times each second (cadence) that a paw takes a complete stride as measured by DigiGait, post infection day 27, hindlimb [n/s] stride_freq_hind 64511 left right	CC	4	both	4wks	N=1

Brinkmeyer1:113	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	spatial length that a paw traverses through a given stride as measured by DigiGait, post infection day 27, forelimb [cm] stride_length_fore 64513 left right	CC	4	both	4wks	N=1

Brinkmeyer1:115	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	spatial length that a paw traverses through a given stride as measured by DigiGait, post infection day 27, hindlimb [cm] stride_length_hind 64515 left right	CC	4	both	4wks	N=1

Brinkmeyer1:117	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length variability as measured by DigiGait, post infection day 27, forelimb [cm] stride_length_var_fore 64517 left right	CC	4	both	4wks	N=1

Brinkmeyer1:119	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length variability as measured by DigiGait, post infection day 27, hindlimb [cm] stride_length_var_hind 64519 left right	CC	4	both	4wks	N=1

Brinkmeyer1:121	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length coefficient of variation as measured by DigiGait, post infection day 27, forelimb [%] stride_length_CV_fore 64521 left right	CC	4	both	4wks	N=1

Brinkmeyer1:123	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length coefficient of variation as measured by DigiGait, post infection day 27, hindlimb [%] stride_length_CV_hind 64523 left right	CC	4	both	4wks	N=1

Brinkmeyer1:125	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	angle that paw makes with long axis of direction of motion of mouse as measured by DigiGait, post infection day 27, forelimb [deg] paw_angle_fore 64525 left right	CC	4	both	4wks	N=1

Brinkmeyer1:127	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	angle that paw makes with long axis of direction of motion of mouse as measured by DigiGait, post infection day 27, hindlimb [deg] paw_angle_hind 64527 left right	CC	4	both	4wks	N=1

Brinkmeyer1:129	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw angle for set of strides recorded as measured by DigiGait, post infection day 27, forelimb [deg] paw_angle_SD_fore 64529 left right	CC	4	both	4wks	N=1

Brinkmeyer1:131	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw angle for set of strides recorded as measured by DigiGait, post infection day 27, hindlimb [deg] paw_angle_SD_hind 64531 left right	CC	4	both	4wks	N=1

Brinkmeyer1:133	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal paw area as measured by DigiGait, post infection day 27, forelimb [cm²] paw_area_max_fore 64533 left right	CC	4	both	4wks	N=1

Brinkmeyer1:135	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal paw area as measured by DigiGait, post infection day 27, hindlimb [cm²] paw_area_max_hind 64535 left right	CC	4	both	4wks	N=1

Brinkmeyer1:137	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw area for set of strides recorded as measured by DigiGait, post infection day 27, forelimb [cm²] paw_area_SD_fore 64537 left right	CC	4	both	4wks	N=1

Brinkmeyer1:139	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw area for set of strides recorded as measured by DigiGait, post infection day 27, hindlimb [cm²] paw_area_SD_hind 64539 left right	CC	4	both	4wks	N=1

Brinkmeyer1:141	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of forelimb stepping to fore limb stepping frequency (coordination metric) as measured by DigiGait, post infection day 27, forelimb [ratio] gait_symmetry_fore 64541 left right	CC	4	both	4wks	N=1

Brinkmeyer1:143	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of forelimb stepping to hind limb stepping frequency (coordination metric) as measured by DigiGait, post infection day 27, hindlimb [ratio] gait_symmetry_hind 64543 left right	CC	4	both	4wks	N=1

Brinkmeyer1:145	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during braking phase as measured by DigiGait, post infection day 27, forelimb [cm²/s] max_area_break_fore 64545 left right	CC	4	both	4wks	N=1

Brinkmeyer1:147	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during braking phase as measured by DigiGait, post infection day 27, hindlimb [cm²/s] max_area_break_hind 64547 left right	CC	4	both	4wks	N=1

Brinkmeyer1:149	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during propulsion phase as measured by DigiGait, post infection day 27, forelimb [cm²/s] max_area_propuls_fore 64549 left right	CC	4	both	4wks	N=1

Brinkmeyer1:151	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during propulsion phase as measured by DigiGait, post infection day 27, hindlimb [cm²/s] max_area_propuls_hind 64551 left right	CC	4	both	4wks	N=1

Brinkmeyer1:153	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	overlap extent of ipsilateral fore and hind paws as measured by DigiGait, post infection day 27, forelimb [cm] overlap_distance_fore 64553 left right	CC	4	both	4wks	N=1

Brinkmeyer1:155	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	overlap extent of ipsilateral fore and hind paws as measured by DigiGait, post infection day 27, hindlimb [cm] overlap_distance_hind 64555 left right	CC	4	both	4wks	N=1

Brinkmeyer1:157	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	extent of overlap between ipsilateral fore and hind paws during full stance (balance metric) as measured by DigiGait, post infection day 27, forelimb [cm] paw_placement_fore 64557 left right	CC	4	both	4wks	N=1

Brinkmeyer1:159	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	extent of overlap between ipsilateral fore and hind paws during full stance (balance metric) as measured by DigiGait, post infection day 27, hindlimb [cm] paw_placement_hind 64559 left right	CC	4	both	4wks	N=1

Brinkmeyer1:161	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	gait variability metric as measured by DigiGait, post infection day 27, forelimb ataxia_coefficient_fore 64561 left right	CC	4	both	4wks	N=1

Brinkmeyer1:163	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	gait variability metric as measured by DigiGait, post infection day 27, hindlimb ataxia_coefficient_hind 64563 left right	CC	4	both	4wks	N=1

Brinkmeyer1:165	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through transverse midline of mouse (kinetics metric) as measured by DigiGait, post infection day 27, forelimb [cm] midline_distance_fore 64565 left right	CC	4	both	4wks	N=1

Brinkmeyer1:167	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through transverse midline of mouse (kinetics metric) as measured by DigiGait, post infection day 27, hindlimb [cm] midline_distance_hind 64567 left right	CC	4	both	4wks	N=1

Brinkmeyer1:169	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through axis of mouse (kinetics metric) as measured by DigiGait, post infection day 27, forelimb [cm] axis_distance_fore 64569 left right	CC	4	both	4wks	N=1

Brinkmeyer1:171	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through axis of mouse (kinetics metric) as measured by DigiGait, post infection day 27, hindlimb [cm] axis_distance_hind 64571 left right	CC	4	both	4wks	N=1

Brinkmeyer1:173	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	perpendicular distance between centroids of either set of axial paws during peak stance as measured by DigiGait, post infection day 27 [cm] stance_width 64573 forelimb hindlimb	CC	4	both	4wks	N=1

Brinkmeyer1:175	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stance width coefficient of variation as measured by DigiGait, post infection day 27 [%] stance_width_CV 64575 forelimb hindlimb	CC	4	both	4wks	N=1

Brinkmeyer1:177	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of left and right stance durations as measured by DigiGait, post infection day 27 [ratio] stance_factor 64577 forelimb hindlimb	CC	4	both	4wks	N=1

Brinkmeyer1:179	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride width variability as measured by DigiGait, post infection day 27 [cm] stride_width_var 64579 forelimb hindlimb	CC	4	both	4wks	N=1

Brinkmeyer1:181	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	angle made between left and right paws as a function of stride length and stance width as measured by DigiGait, post infection day 27 [deg] step_angle 64581 forelimb hindlimb	CC	4	both	4wks	N=1

Brinkmeyer1:183	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	step angle variability (standard deviation of step angle for set of strides recorded) as measured by DigiGait, post infection day 27 [deg] step_angle_SD 64583 forelimb hindlimb	CC	4	both	4wks	N=1

Brinkmeyer1:185	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	step angle coefficient of variation as measured by DigiGait, post infection day 27 [%] step_angle_CV 64585 forelimb hindlimb	CC	4	both	4wks	N=1

Brinkmeyer1:187	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	length of forelimb steps as measured by foot print analysis, post infection [cm] length_fore 64587 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2

Brinkmeyer1:194	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	width of forelimb steps as measured by foot print analysis, post infection [cm] width_fore 64594 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2

Brinkmeyer1:201	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	length of hindlimb steps as measured by foot print analysis, post infection [cm] length_hind 64601 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2

Brinkmeyer1:208	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	width of hindlimb steps as measured by foot print analysis, post infection [cm] width_hind 64608 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2

Brinkmeyer1:215	Brinkmeyer1	rotarod	Theiler's murine encephalomyelitis virus	time to fall from accelerating rotarod, post infection wk 7 [s] rotarod 64615 trial 1 trial 2 trial 3 trial 4 trial 5 trial 6 trial 7 trial 8 trial 9	CC	5	both	4wks	N=2