Brinkmeyer1: Susceptibility to Theiler's murine encephalomyelitis virus in 5 Collaborative Cross strains of mice (2017)

Brinkmeyer-Langford CL, Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ, Threadgill DW. Host genetic background influences diverse neurological responses to viral infection in mice. Sci Rep. 2017 Sep 22;7(1):12194. doi: 10.1038/s41598-017-12477-2.   PubMed 28939838     FullText


         
Brinkmeyer1 downloads
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• Brinkmeyer1 supplementary data
Participants Candice L Brinkmeyer-Langford       Texas A&M University,  College Station, TX
David W Threadgill       Texas A&M University,  College Station, TX
With: Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ
ContactCandice L Brinkmeyer-Langford     Brinkmeyer@tamu.edu     Lab web site
Project type Phenotype strain survey data set
MPD identifiersBrinkmeyer1     MPD:644
Data changelog No updates/corrections.       Initial release date: 04/2019.
Formatted citation
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This study assessed the phenotypic consequences of TMEV infection in 5 CC strains of mice. Outcomes of long-term infection (3 mo) and acute vs. early chronic infection (7 vs. 28 d post infection) were evaluated using neurological and behavioral phenotyping tests along with body weight and clinical scores. Data for mock infected mice are in a supplemental data download file.

Summary of procedures that were conducted
• body weight
• health assessment Clinical health assessment scores, TMEV infection.
• RNA expression profiling TMEV transcript abundance.
• open field test Locomotor activity, TMEV infection.
• gait analysis DigiGait analysis and footprint analysis, TMEV infection.
• rotarod Latency to fall from accelerating rotarod, TMEV infection.
Mice: CC   5 strains   ♀♂   age 4wks   2 cohorts