Brinkmeyer1: Susceptibility to Theiler's murine encephalomyelitis virus in 5 Collaborative Cross strains of mice (2017)

Brinkmeyer-Langford CL, Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ, Threadgill DW. Host genetic background influences diverse neurological responses to viral infection in mice. Sci Rep. 2017 Sep 22;7(1):12194. doi: 10.1038/s41598-017-12477-2.   PubMed 28939838     FullText


         
This study assessed the phenotypic consequences of TMEV infection in 5 CC strains of mice. Outcomes of long-term infection (3 mo) and acute vs. early chronic infection (7 vs. 28 d post infection) were evaluated using neurological and behavioral phenotyping tests along with body weight and clinical scores. Data for mock infected mice are in a supplemental data download file.

Experimental groups in this study:
• None     • None    

Procedures conducted:
• body weight 
• health assessment  Clinical health assessment scores, TMEV infection.
• RNA expression profiling  TMEV transcript abundance.
• open field test  Locomotor activity, TMEV infection.
• gait analysis  DigiGait analysis and footprint analysis, TMEV infection.
• rotarod  Latency to fall from accelerating rotarod, TMEV infection.

Brinkmeyer1 downloads
• Download Brinkmeyer1 project data set     animal data, as uploaded
• Download Brinkmeyer1 animal data matrix     with factor-related expansion applied as necessary
• Download Brinkmeyer1 strain means, SD, N, etc.     one row per strain/sex/measure
• Brinkmeyer1 supplementary data
Investigators Candice L Brinkmeyer-Langford       Texas A&M University,  College Station, TX
David W Threadgill       Texas A&M University,  College Station, TX
Participants Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ
ContactCandice L Brinkmeyer-Langford     Brinkmeyer@tamu.edu     Lab web site
Project type Phenotype strain survey data set
MPD identifiersBrinkmeyer1     MPD:644
Data changelog No updates/corrections.       Initial release date: 04/2019.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice: CC   5 strains   ♀♂   age 4wks   2 experimental groups

Select table page: First Prev 1 - 10 / 85 (85) Next Last
Sort/
Pick
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
    Brinkmeyer1 body weight Theiler's murine encephalomyelitis virus body weight, post infection   [g]  bw   64401     day 0    day 2    day 4    day 6    day 8    day 10    day 14    day 17    day 22    day 27    (6 more)... CC 5 both 4wks N=5
    Brinkmeyer1 health assessment Theiler's murine encephalomyelitis virus clinical score (0=normal, 6=moribund), post infection   [score]  clin_score   64417     day 0    day 2    day 4    day 6    day 8    day 12    day 18    day 24    day 29    day 34    (6 more)... CC 5 both 4wks N=5
    Brinkmeyer1 RNA expression profiling Theiler's murine encephalomyelitis virus TMEV transcript abundance (normalized), post infection  TMEV   64433     day 7    day 28 CC 4 both 4wks N=1
    Brinkmeyer1 open field test Theiler's murine encephalomyelitis virus number of seconds spent grooming, 10 min test, post infection wk 3 (manual assessment)   [s]  grooming   64435 CC 5 both 4wks N=2
    Brinkmeyer1 open field test Theiler's murine encephalomyelitis virus number of times mouse reared, 10 min test, post infection wk 3 (manual assessment)   [n]  activity_rearing   64436 CC 5 both 4wks N=2
    Brinkmeyer1 open field test Theiler's murine encephalomyelitis virus horizontal movement latency, 30 min test, post infection wk 3   [s]  horiz_latency   64437     trial 1    trial 2 CC 4 both 4wks N=2
    Brinkmeyer1 open field test Theiler's murine encephalomyelitis virus number of horizontal movements (beam breaks), 30 min test, post infection wk 3   [n]  horiz_activity   64439     trial 1    trial 2 CC 4 both 4wks N=2
    Brinkmeyer1 open field test Theiler's murine encephalomyelitis virus horizontal distance traveled, 30 min test, post infection wk 3   [cm]  horiz_distance   64441     trial 1    trial 2 CC 4 both 4wks N=2
    Brinkmeyer1 open field test Theiler's murine encephalomyelitis virus time spent moving horizontally, 30 min test, post infection wk 3   [s]  horiz_time   64443     trial 1    trial 2 CC 4 both 4wks N=2
    Brinkmeyer1 open field test Theiler's murine encephalomyelitis virus horizontal movement velocity, 30 min test, post infection wk 3   [cm/s]  horiz_velocity   64445     trial 1    trial 2 CC 4 both 4wks N=2
    All boxes             To see more rows use the paging control at top.


Analysis Tools

  MEASURES (0/0)
Data set
MPD ID
Procedure / Protocol
Treatment
Phenotype Measure / Variable
Panel
No. of Strains
Sex
Age
    All boxes