Recla2: Late phase formalin pain response in a Diversity Outbred (DO) mouse population (2019)
Recla JM, Bubier JA, Gatti DM, Ryan JL, Long KH, Robledo RF, Glidden NC, Hou G, Churchill GA, Maser RS, Zhang ZW, Young EE, Chesler EJ, Bult CJ. Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.
Pain. 2019 Aug;160(8):1740-1753. doi: 10.1097/j.pain.0000000000001571.
Recla2 downloads
• Download Recla2 project data set animal data, as uploaded
• Download Recla2 animal data matrix with factor-related expansion applied as necessary
• Download Recla2 strain means, SD, N, etc. one row per strain/sex/measure
• Recla2 supplementary data
• Download Recla2 project data set animal data, as uploaded
• Download Recla2 animal data matrix with factor-related expansion applied as necessary
• Download Recla2 strain means, SD, N, etc. one row per strain/sex/measure
• Recla2 supplementary data
Ontology terms mapped to Recla2 measures:
| Investigators |
Jill M Recla The Jackson Laboratory, Bar Harbor, ME Jason A Bubier The Jackson Laboratory, Bar Harbor, ME Daniel M Gatti The Jackson Laboratory, Bar Harbor, ME Jennifer L Ryan The Jackson Laboratory, Bar Harbor, ME Raymond F Robledo The Jackson Laboratory, Bar Harbor, ME Gary A Churchill The Jackson Laboratory, Bar Harbor, ME Elissa J Chesler The Jackson Laboratory, Bar Harbor, ME Carol J Bult The Jackson Laboratory, Bar Harbor, ME |
| Participants | Long KH, Garrett AM, Glidden N, Maser RS, Zhang A-W, Burgess RW, Young EE |
| Contact | Jill M Recla jill.recla@jax.org
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| Acknowledgements | Funding provided by NIH DA37927, AA18776, CA034196; DOD grant W81XWH-11-1-0762 |
| Phenotype strain survey data set | |
| MPD identifiers | Recla2 MPD:627 |
| No updates/corrections. Initial release date: 09/2019. | |
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Click above to copy-paste the entire citation for this MPD web page. |
Late phase response to formalin injection was measured in Diversity Outbred mice genotyped for over 70,000 SNPs (SNP data can be retrieved from dodb.jax.org and searching on 'Recla' ). A QTL, Nociq4, was identified which contains the well-known pain gene Trpa1. Functional consequences of sequence variants in Trpa1 were characterized by isoform expression. These qRT-PCR data are available in a supplementary data file.
Procedures conducted:
Procedures conducted:
| Formalin injection. |
