MPD: Data set: GMC02

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14. PubMed 32060626 FullText

GMC02 downloads
• Download GMC02 project data set animal data, as uploaded
• Download GMC02 animal data matrix with factor-related expansion applied as necessary
• Download GMC02 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to GMC02 measures:

MA:0000615 forelimb muscle
MA:0000692 limb muscle
MP:0001259 abnormal body weight
MP:0001515 abnormal grip strength
VT:0001259 body mass
VT:0004262 physical strength trait
VT:0010080 skeletal muscle physiology trait

Institutional authorship	German Mouse Clinic and Department of Infection Genetics, HZI Lab web site
Investigators	GMC Management Team German Mouse Clinic, Neuherberg GERMANY
Participants	Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Becker L, Klopstock T, Lengger C, Kollmus H, Schughart K
Contact	GMC Management Team coregmc@helmholtz-muenchen.de Lab web site
Affiliated Center	German Mouse Clinic (GMC)
Acknowledgements	Funding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type	Phenotype strain survey data set
MPD identifiers	GMC02 MPD:551
Data changelog	No updates/corrections. Initial release date: 02/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

The grip strength test is used to measure neuromuscular function as maximal muscle strength of forelimbs, and combined forelimbs and hindlimbs. These are assessed by grasping a grid that is connected to a sensor. Three trials are carried out in succession measuring forelimb strength only, followed by three successive trials measuring the combined forelimb/hindlimb grip strength.

Experimental groups in this study:
• None • None • None • None • None

Procedures conducted:

• grip strength

Several trials.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
GMC02:1	GMC02	body weight	(none)	body weight [g] bw 55101	inbred w/CC8	8	both	8-10wks	N=17

GMC02:11	GMC02	grip strength	(none)	forelimb grip strength [g] front_paws 55111 trial1 trial2 trial3	inbred w/CC8	8	both	8-10wks	N=17

GMC02:14	GMC02	grip strength	(none)	forelimb grip strength, mean [g] front_paws_mean 55114	inbred w/CC8	8	both	8-10wks	N=17

GMC02:15	GMC02	grip strength	(none)	forelimb grip strength (mean) normalized to body weight [ratio] front_paws_adj 55115	inbred w/CC8	8	both	8-10wks	N=17

GMC02:21	GMC02	grip strength	(none)	forelimb and hindlimb grip strength [g] all_paws 55121 trial1 trial2 trial3	inbred w/CC8	8	both	8-10wks	N=17

GMC02:24	GMC02	grip strength	(none)	forelimb and hindlimb grip strength, mean [g] all_paws_mean 55124	inbred w/CC8	8	both	8-10wks	N=17

GMC02:25	GMC02	grip strength	(none)	forelimb and hindlimb grip strength (mean) normalized to body weight [ratio] all_paws_adj 55125	inbred w/CC8	8	both	8-10wks	N=17

GMC02: Grip strength in 8 inbred founder strains of the Collaborative Cross (2020)