Graham1: West Nile virus infection in males of F1 hybrids (RIX) of Collaborative Cross strains of mice (2015)

Graham JB, Thomas S, Swarts J, McMillan AA, Ferris MT, Suthar MS, Treuting PM, Ireton R, Gale M Jr, Lund JM. Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes. MBio. 2015 May 5;6(3):e00493-15. doi: 10.1128/mBio.00493-15.   PubMed 25944860  


         
Graham1 downloads
• Download Graham1 project data set     animal data, as uploaded
• Download Graham1 animal data matrix     with factor-related expansion applied as necessary
• Download Graham1 strain means, SD, N, etc.     one row per strain/sex/measure
• Graham1 supplementary data
Investigators Jessica B Graham       Fred Hutchinson Cancer Research Center,  Seattle, WA
Sunil Thomas       University of Washington,  Seattle, WA
Michael Gale Jr.       University of Washington,  Seattle, WA
Jennifer M Lund       Fred Hutchinson Cancer Research Center,  Seattle, WA
Participants Swarts J, McMillan AA, Ferris MT, Suthar MS, Treuting PM, Ireton R
ContactJessica B Graham     jgraham@fredhutch.org     Lab web site
AcknowledgementsFunding provided by NIH AI100625, AI04002, AI083019
Project type Phenotype strain survey data set
MPD identifiersGraham1     MPD:633
Data changelog No updates/corrections.       Initial release date: 11/2018.
Formatted citation
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Procedures conducted:
• body weight 
• health assessment  Clinical score.
• immune cell quantification  T cell populations in brain and spleen.
• RNA expression profiling  Viral load and expression of Ifnb1 and Ifit1 in brain, kidney and spleen.

Mice: CC RIX   5 strains   ♂   age 8-10wks   9 experimental groups