MPD: Data set: Lesage1

Collin R, Balmer L, Morahan G, Lesage S. Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross. J Immunol. 2019 Feb 1;202(3):777-786. doi: 10.4049/jimmunol.1801247. Epub 2018 Dec 26. PubMed 30587532

Lesage1 downloads
• Download Lesage1 project data set animal data, as uploaded
• Download Lesage1 project data set animal data, as uploaded
• Download Lesage1 animal data matrix with factor-related expansion applied as necessary
• Download Lesage1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Lesage1 measures:

MA:0000141 spleen
MP:0000717 abnormal lymphocyte cell number
MP:0002407 abnormal double-negative T cell morphology
MP:0006387 abnormal T cell number
MP:0008038 abnormal NK T cell number
MP:0008043 abnormal NK cell number
MP:0008073 abnormal CD4-positive, alpha beta T cell number
MP:0008077 abnormal CD8-positive, alpha-beta T cell number
MP:0008125 abnormal dendritic cell number
VT:0000717 lymphocyte quantity
VT:0005089 double-negative T cell quantity
VT:0006387 T cell quantity
VT:0008038 NK T cell quantity
VT:0008073 CD4-positive T cell quantity
VT:0008077 CD8-positive T cell quantity
VT:0008125 dendritic cell quantity

Investigators	Sylvie Lesage University of Montreal, Montreal, Quebec CANADA Roxanne Collin University of Montreal, Montreal, Quebec CANADA Lois Balmer Harry Perkins Institute of Medical Research, Nedlands, Western Australia AUSTRALIA Grant Morahan Harry Perkins Institute of Medical Research, Nedlands, Western Australia AUSTRALIA
Contact	Sylvie Lesage sylvie.lesage@umontreal.ca
Project type	Phenotype strain survey data set
MPD identifiers	Lesage1 MPD:635
Data changelog	No updates/corrections. Initial release date: 03/2019.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Collaborative Cross mice were provided by Geniad Pty Ltd and bred at the Animal Resource Centre (Australia, WA, Perth). Where possible, standard CC strain nomenclature is used. The download file contains strain aliases. Collaborative Cross founder strains were obtained from The Jackson Laboratory and analyzed separately from the CC strains at the Maisonneuve-Rosemont Hospital Research Center (Montreal, Quebec, Canada).

Procedures conducted:

• immune cell quantification

Immunological cell variation.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Lesage1:1	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD3- [%] CD3_neg 63501	CC w/par	76	both	5-8wks	N=2

Lesage1:2	Lesage1	immune cell quantification	(none)	percentage of splenic CD3- lymphocytes that are NK cells (CD49+ CD19-) [%] NK_cells_of_CD3_neg 63502	CC w/par	76	both	5-8wks	N=2

Lesage1:3	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are NK cells (CD49+ CD19-) [%] NK_cells_of_tot 63503	CC w/par	76	both	5-8wks	N=2

Lesage1:4	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27- CD11b- [%] CD27_neg_CD11b_neg 63504	CC w/par	76	both	5-8wks	N=2

Lesage1:5	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27+ CD11b- [%] CD27_pos_CD11b_neg 63505	CC w/par	76	both	5-8wks	N=2

Lesage1:6	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27+ CD11b+ [%] CD27_pos_CD11b_pos 63506	CC w/par	76	both	5-8wks	N=2

Lesage1:7	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are CD27- CD11b+ [%] CD27_neg_CD11b_pos 63507	CC w/par	76	both	5-8wks	N=2

Lesage1:8	Lesage1	immune cell quantification	(none)	percentage of splenic NK cells that are pre-mNK (B220+ CD11c+) [%] pre_mNK_of_NK 63508	CC w/par	76	both	5-8wks	N=2

Lesage1:9	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are pre-mNK (B220+ CD11c+) [%] pre_mNK_of_tot 63509	CC w/par	76	both	5-8wks	N=2

Lesage1:10	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are NK T cells (TCRb+ CD1d+) [%] NKT_cells 63510	CC w/par	76	both	5-8wks	N=2

Lesage1:11	Lesage1	immune cell quantification	(none)	percentage of splenic NK T cells that are CD4+ CD8- [%] CD4_pos_CD8_neg_of_NKT 63511	CC w/par	76	both	5-8wks	N=2

Lesage1:12	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4+ NK T cells [%] CD4_pos_CD8_neg_NKT_of_tot 63512	CC w/par	76	both	5-8wks	N=2

Lesage1:13	Lesage1	immune cell quantification	(none)	percentage of splenic NK T cells that are CD4- CD8- [%] CD4_neg_CD8_neg_of_NKT 63513	CC w/par	76	both	5-8wks	N=2

Lesage1:14	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4- CD8- NK T cells [%] CD4_neg_CD8_neg_NKT_of_tot 63514	CC w/par	76	both	5-8wks	N=2

Lesage1:15	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are T cells [%] T_cells 63515	CC w/par	76	both	5-8wks	N=2

Lesage1:16	Lesage1	immune cell quantification	(none)	percentage of splenic T cells that are CD4+ CD8- [%] CD4_pos_CD8_neg_of_Tcells 63516	CC w/par	76	both	5-8wks	N=2

Lesage1:17	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4+ T cells [%] CD4_pos_CD8_neg_of_tot 63517	CC w/par	76	both	5-8wks	N=2

Lesage1:18	Lesage1	immune cell quantification	(none)	percentage of splenic T cells that are CD4- CD8+ [%] CD4_neg_CD8_pos_of_Tcells 63518	CC w/par	76	both	5-8wks	N=2

Lesage1:19	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD8+ T cells [%] CD4_neg_CD8_pos_of_tot 63519	CC w/par	76	both	5-8wks	N=2

Lesage1:20	Lesage1	immune cell quantification	(none)	percentage of splenic T cells that are CD4- CD8- [%] CD4_neg_CD8_neg_of_Tcells 63520	CC w/par	76	both	5-8wks	N=2

Lesage1:21	Lesage1	immune cell quantification	(none)	percentage of splenic lymphocytes that are CD4- CD8- T cells [%] CD4_neg_CD8_neg_of_tot 63521	CC w/par	76	both	5-8wks	N=2

Lesage1:22	Lesage1	immune cell quantification	(none)	ratio of splenic CD4+ to CD8+ T cells [ratio] CD4_CD8_ratio 63522	CC w/par	76	both	5-8wks	N=2

Lesage1:23	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are plasmacytoid dendritic cells [%] pDC 63523	CC w/par	74	both	5-8wks	N=2

Lesage1:24	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are conventional dendritic cells [%] cDC 63524	CC w/par	74	both	5-8wks	N=2

Lesage1:25	Lesage1	immune cell quantification	(none)	percentage of splenic conventional dendritic cells that are merocytic [%] mDC_of_cDC 63525	CC w/par	74	both	5-8wks	N=2

Lesage1:26	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are merocytic dendritic cells [%] mDC_of_tot 63526	CC w/par	74	both	5-8wks	N=2

Lesage1:27	Lesage1	immune cell quantification	(none)	percentage of splenic conventional dendritic cells that are cDC1 [%] cDC1_of_cDC 63527	CC w/par	74	both	5-8wks	N=2

Lesage1:28	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are cDC1 conventional dendritic cells [%] cDC1_of_tot 63528	CC w/par	74	both	5-8wks	N=2

Lesage1:29	Lesage1	immune cell quantification	(none)	percentage of splenic conventional dendritic cells that are cDC2 [%] cDC2_of_cDC 63529	CC w/par	74	both	5-8wks	N=2

Lesage1:30	Lesage1	immune cell quantification	(none)	percentage of splenic leukocytes that are cDC2 conventional dendritic cells [%] cDC2_of_tot 63530	CC w/par	74	both	5-8wks	N=2

Lesage1: Immunological variation in 68 Collaborative Cross strains of mice and 8 founder strains (2018)