Neuner1: Motor function, spatial learning and memory function, anxiety-related behaviors, and beta-amyloid levels in Alzheimer’s Disease mouse models (AD-BXD) (2019)

Neuner SM, Heuer SE, Huentelman MJ, O'Connell KMS, Kaczorowski CC. Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine. Neuron. 2019 Feb 6;101(3):399-411.e5. doi: 10.1016/j.neuron.2018.11.040. Epub 2018 Dec 27.   PubMed 30595332  

Neuner SM, Heuer SE, Zhang JG, Philip VM, Kaczorowski CC. Identification of Pre-symptomatic Gene Signatures That Predict Resilience to Cognitive Decline in the Genetically Diverse AD-BXD Model. Front Genet. 2019 Feb 6;10:35. doi: 10.3389/fgene.2019.00035. eCollection 2019.   PubMed 30787942     FullText

Neuner1 downloads
• Download Neuner1 project data set     animal data, as uploaded
• Download Neuner1 animal data matrix     with factor-related expansion applied as necessary
• Download Neuner1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Sarah M Neuner       The Jackson Laboratory,  Bar Harbor, ME
Catherine C Kaczorowski       The Jackson Laboratory,  Bar Harbor, ME
Participants Heuer SE, Huentelman MJ, O’Connell KMS, Zhang JG, Philip VM
ContactCatherine C Kaczorowski     Lab web site
AcknowledgementsFunding provided by NIH AG057914, AG054180, AG050357, AG059778, DK102918; BrightFocus Foundation A2016397S
Project type Phenotype strain survey data set
MPD identifiersNeuner1     MPD:659
Data changelog No updates/corrections.       Initial release date: 11/2019.
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Procedures conducted:
• body weight  Measured every 2 mo, starting at age 2 mo to 16 mo.
• biomarker quantification  Temporal cortex amyloid level, age 6 and 14 mo.
• Y-maze  Spontaneous alternation and other parameters measured every 2 mo, from age 2 to 16 mo.
• balance beam  Time to cross narrow beam, age 6 and 14 mo.
• inclined screen test  Time to right body, age 6 and 14 mo.
• grip strength  Grip strength across 3 trials, age 6 mo and 14 mo.
• behavior observation  Sensorimotor composite score, age 6 mo and 14 mo.
• elevated plus maze  Distance traveled and arm entries, age 6 mo and 14 mo.
• fear conditioning test  Time spent freezing, age 6 mo and 14 mo.

Mice: F1 AD-BXD   55 strains   ♀♂   age 7-65wks   1 experimental group