MPD: Data set: McMullan6

McMullan RC, Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE, de Villena FP. CC002/Unc females are mouse models of exercise-induced paradoxical fat response. Physiol Rep. 2018 Jun;6(12):e13716. doi: 10.14814/phy2.13716. PubMed 29924460

Four strains were selected based on the following criteria: 1) ability to run on treadmills, 2) fat response type to voluntary exercise, 3) endurance ability (MPD datasets: McMullan1, McMullan2, McMullan3; McMullan4; all data was collected in older females). Selected strains were: CC002/Unc adverse fat responder, low endurance; CC027/GeniUnc adverse fat responder, high endurance; CC013/GeniUnc standard fat responder, low endurance; and CC037/TauUnc standard fat responder, high endurance. Body weight and composition were assessed before and after 4 wks of forced exercise on a treadmill.

Experimental groups in this study:
• None • None • None

Procedures conducted:

• body weight		Body weight before and after 4 weeks of treadmill-based exercise training. 3 intensity cohorts.
• MRI		Body composition (fat and lean mass) before and after 4 weeks of treadmill-based exercise training. 3 intensity cohorts.

McMullan6 downloads
• Download McMullan6 project data set animal data, as uploaded
• Download McMullan6 animal data matrix with factor-related expansion applied as necessary
• Download McMullan6 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to McMullan6 measures:

MA:0000009 adipose tissue
MP:0001259 abnormal body weight
MP:0003959 abnormal lean body mass
MP:0005457 abnormal percent body fat/body weight
VT:0001259 body mass
VT:0005452 adipose amount
VT:0010482 body fat mass
VT:0010483 body lean mass

Investigators	Rachel C McMullan University of North Carolina, Chapel Hill, NC Fernando Pardo-Manuel de Villena University of North Carolina, Chapel Hill, NC
Participants	Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE
Contact	Fernando Pardo-Manuel de Villena fernando@med.unc.edu Lab web site
Part of a series:	• McMullan6 (this project) McMullan6 • McMullan7 see McMullan7
Acknowledgements	Funding provided by NIH DK056350, AI100625, AI109761, AG049092, MH100241, DK05350, Al100625
Project type	Phenotype strain survey data set
MPD identifiers	McMullan6 MPD:615
Data changelog	No updates/corrections. Initial release date: 07/2018.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
McMullan6:1	McMullan6	body weight	(none)	body weight at start of experiment [g] bw_start 61501 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:6	McMullan6	body weight	exercise	body weight at after 4 wks of treatment [g] bw_end 61506 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:11	McMullan6	body weight	exercise	body weight, response to 4 wks of treatment [%] bw_resp 61511 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:16	McMullan6	MRI	(none)	percentage of body mass that is fat at start of experiment [%] fat_start 61516 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:21	McMullan6	MRI	exercise	percentage of body mass that is fat after 4 wks of treatment [%] fat_end 61521 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:26	McMullan6	MRI	exercise	percentage of body mass that is fat, response after 4 wks of treatment [%] fat_resp 61526 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:31	McMullan6	MRI	(none)	percentage of body mass that is lean at start of experiment [%] lean_start 61531 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:36	McMullan6	MRI	exercise	percentage of body mass that is lean after 4 wks of treatment [%] lean_end 61536 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6:41	McMullan6	MRI	exercise	percentage of body mass that is lean, response after 4 wks of treatment [%] lean_resp 61541 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan6: Body weight and composition after forced exercise in 4 Collaborative Cross strains of mice (2018)