McMullan6: Body weight and composition after forced exercise in 4 Collaborative Cross strains of mice (2018)

McMullan RC, Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE, de Villena FP. CC002/Unc females are mouse models of exercise-induced paradoxical fat response. Physiol Rep. 2018 Jun;6(12):e13716. doi: 10.14814/phy2.13716.   PubMed 29924460  


         
McMullan6 downloads
• Download McMullan6 project data set     one row per animal, one column per trait
• Download McMullan6 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Rachel C McMullan       University of North Carolina,  Chapel Hill, NC
Fernando Pardo-Manuel de Villena       University of North Carolina,  Chapel Hill, NC
With: Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE
ContactFernando Pardo-Manuel de Villena     fernando@med.unc.edu     Lab web site
Part of a series: • McMullan6   (this project) McMullan6
• McMullan7   see McMullan7
AcknowledgementsFunding provided by NIH DK056350, AI100625, AI109761, AG049092, MH100241, DK05350, Al100625
Project type Phenotype strain survey data set
MPD identifiersMcMullan6     MPD:615
Data changelog No updates/corrections.       Initial release date: 07/2018.
Formatted citation
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Four strains were selected based on the following criteria: 1) ability to run on treadmills, 2) fat response type to voluntary exercise, 3) endurance ability (MPD datasets: McMullan1, McMullan2, McMullan3; McMullan4; all data was collected in older females). Selected strains were: CC002/Unc adverse fat responder, low endurance; CC027/GeniUnc adverse fat responder, high endurance; CC013/GeniUnc standard fat responder, low endurance; and CC037/TauUnc standard fat responder, high endurance. Body weight and composition were assessed before and after 4 wks of forced exercise on a treadmill.

Summary of procedures that were conducted
• body weight Body weight before and after 4 weeks of treadmill-based exercise training. 3 intensity cohorts.
• MRI Body composition (fat and lean mass) before and after 4 weeks of treadmill-based exercise training. 3 intensity cohorts.
Mice: CC   4 strains   ♀♂   age 8-10wks   3 cohorts