GMC16: Clinical blood chemistry for 8 inbred founder strains of the Collaborative Cross (2020)

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.   PubMed 32060626     FullText

          List all GMC measures
GMC16 downloads
• Download GMC16 project data set     animal data, as uploaded
• Download GMC16 animal data matrix     with factor-related expansion applied as necessary
• Download GMC16 strain means, SD, N, etc.     one row per strain/sex/measure
• GMC16 supplementary data
Ontology terms mapped to GMC16 measures:
    MA:0002501   plasma
    MP:0000180   abnormal circulating cholesterol level
    MP:0000188   abnormal circulating glucose level
    MP:0000199   abnormal circulating serum albumin level
    MP:0000202   abnormal circulating alkaline phosphatase level
    MP:0000203   abnormal circulating aspartate transaminase level
    MP:0001259   abnormal body weight
    MP:0001562   abnormal circulating calcium level
    MP:0001565   abnormal circulating phosphate level
    MP:0001573   abnormal circulating alanine transaminase level
    MP:0001776   abnormal circulating sodium level
    MP:0002668   abnormal circulating potassium level
    MP:0002943   abnormal lactate dehydrogenase level
    MP:0003018   abnormal circulating chloride level
    MP:0004152   abnormal circulating iron level
    MP:0005265   abnormal blood urea nitrogen level
    MP:0005328   abnormal circulating creatinine level
    MP:0008804   abnormal circulating amylase level
    MP:0011888   abnormal circulating total protein level
    MP:0011969   abnormal circulating triglyceride level
    MP:0013403   abnormal circulating lactate level
    VT:0000180   blood cholesterol amount
    VT:0000188   blood glucose amount
    VT:0000199   blood albumin amount
    VT:0000202   blood alkaline phosphatase amount
    VT:0000203   blood aspartate transaminase amount
    VT:0001259   body mass
    VT:0001562   blood calcium amount
    VT:0001565   blood phosphate amount
    VT:0001570   blood enzyme amount
    VT:0001573   blood alanine transaminase amount
    VT:0001776   blood sodium amount
    VT:0002644   blood triglyceride amount
    VT:0002668   blood potassium amount
    VT:0003018   blood chloride amount
    VT:0004152   blood iron amount
    VT:0005265   blood urea nitrogen amount
    VT:0005328   blood creatinine amount
    VT:0005567   blood total protein amount
    VT:0010475   blood amylase amount
    VT:0010616   blood lactate amount
Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Rathkolb B, Wolf E, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC16     MPD:565
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Experimental groups in this study:
• None     • None     • None     • None    

Procedures conducted:
• metabolic panel  Clinical blood chemistry (plasma). No fast.
• lipid profile  Cholesterol, triglycerides. No fast, plasma.

Mice: inbred w/CC8   8 strains   ♀♂   age 16-17, 20-21wks   4 experimental groups