GMC16: Clinical blood chemistry for 8 inbred founder strains of the Collaborative Cross (2020)

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.   PubMed 32060626     FullText


          List all GMC measures
Experimental groups in this study:
• None     • None     • None     • None    

Procedures conducted:
• metabolic panel  Clinical blood chemistry (plasma). No fast.
• lipid profile  Cholesterol, triglycerides. No fast, plasma.

GMC16 downloads
• Download GMC16 project data set     animal data, as uploaded
• Download GMC16 animal data matrix     with factor-related expansion applied as necessary
• Download GMC16 strain means, SD, N, etc.     one row per strain/sex/measure
• GMC16 supplementary data
Ontology terms mapped to GMC16 measures:
  MA:0002501   plasma
  MP:0000180   abnormal circulating cholesterol level
  MP:0000188   abnormal circulating glucose level
  MP:0000199   abnormal circulating serum albumin level
  MP:0000202   abnormal circulating alkaline phosphatase level
  MP:0000203   abnormal circulating aspartate transaminase level
  MP:0001259   abnormal body weight
  MP:0001562   abnormal circulating calcium level
  MP:0001565   abnormal circulating phosphate level
  MP:0001573   abnormal circulating alanine transaminase level
  MP:0001776   abnormal circulating sodium level
  MP:0002668   abnormal circulating potassium level
  MP:0002943   abnormal lactate dehydrogenase level
  MP:0003018   abnormal circulating chloride level
  MP:0004152   abnormal circulating iron level
  MP:0005265   abnormal blood urea nitrogen level
  MP:0005328   abnormal circulating creatinine level
  MP:0008804   abnormal circulating amylase level
  MP:0011888   abnormal circulating total protein level
  MP:0011969   abnormal circulating triglyceride level
  MP:0013403   abnormal circulating lactate level
  VT:0000180   blood cholesterol amount
  VT:0000188   blood glucose amount
  VT:0000199   blood albumin amount
  VT:0000202   blood alkaline phosphatase amount
  VT:0000203   blood aspartate transaminase amount
  VT:0001259   body mass
  VT:0001562   blood calcium amount
  VT:0001565   blood phosphate amount
  VT:0001570   blood enzyme amount
  VT:0001573   blood alanine transaminase amount
  VT:0001776   blood sodium amount
  VT:0002644   blood triglyceride amount
  VT:0002668   blood potassium amount
  VT:0003018   blood chloride amount
  VT:0004152   blood iron amount
  VT:0005265   blood urea nitrogen amount
  VT:0005328   blood creatinine amount
  VT:0005567   blood total protein amount
  VT:0010475   blood amylase amount
  VT:0010616   blood lactate amount

Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Rathkolb B, Wolf E, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC16     MPD:565
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice: inbred w/CC8   8 strains   ♀♂   age 16-17, 20-21wks   4 experimental groups

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    GMC16 body weight (none) body weight   [g]  bw   56501     age 16-17wks    20-21wks inbred w/CC8 8 both N=7
    GMC16 metabolic panel (none) calcium (plasma Ca)   [mmol/L]  calcium   56510     age 16-17wks    20-21wks inbred w/CC8 8 both N=7
    GMC16 metabolic panel (none) chloride (plasma Cl)   [mmol/L]  chloride   56512     age 16-17wks    20-21wks inbred w/CC8 8 both N=7
    GMC16 metabolic panel (none) iron (plasma Fe)   [µmol/L]  iron   56514     age 16-17wks    20-21wks inbred w/CC8 8 both N=7
    GMC16 metabolic panel (none) unsaturated iron binding capacity (plasma UIBC)   [µmol/L]  iron_binding_21   56516 inbred w/CC8 6 both N=3
    GMC16 metabolic panel (none) lactate (plasma)   [mmol/L]  lactate   56518     age 16-17wks    20-21wks inbred w/CC8 8 both N=7
    GMC16 metabolic panel (none) phosphorus (plasma phosphate)   [mmol/L]  phosphate   56520     age 16-17wks    20-21wks inbred w/CC8 8 both N=7
    GMC16 metabolic panel (none) potassium (plasma K)   [mmol/L]  potassium   56522     age 16-17wks    20-21wks inbred w/CC8 8 both N=6
    GMC16 metabolic panel (none) sodium (plasma Na)   [mmol/L]  sodium   56524     age 16-17wks    20-21wks inbred w/CC8 8 both N=6
    GMC16 metabolic panel (none) alkaline phosphatase (plasma ALP)   [IU/L]  ALP   56526     age 16-17wks    20-21wks inbred w/CC8 8 both N=7
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