MPD: Data set: Xenakis1

Giusti-Rodríguez P, Xenakis JG, Crowley JJ, Nonneman RJ, DeCristo DM, Ryan A, Quackenbush CR, Miller DR, Shaw GD, Zhabotynsky V, Sullivan PF, Manuel de Villena FP, Zou F. Antipsychotic Behavioral Phenotypes in the Mouse Collaborative Cross Recombinant Inbred Inter-Crosses (RIX). G3 (Bethesda). 2020 Sep 2;10(9):3165-3177. doi: 10.1534/g3.120.400975. PubMed 32694196 FullText

A battery of behavioral tests were performed in 73 RIX lines treated with haloperidol or placebo in order to monitor the development of antipsychotic-induced adverse drug reactions.

Note on studied population: Six mice were removed from the study due to technical difficulties in phenotyping.

Experimental groups in this study:
• Haloperidol treatment group • Placebo treatment group

Procedures conducted:

• body weight
• inclined screen test		Latency to move all four paws.
• open field test		Locomotor activity, anxiety, stereotypy.
• behavior observation		Vacuous chewing, tongue protrusion, jaw tremor.
• drug and metabolite quantification		Plasma haloperidol concentration.

Xenakis1 downloads
• Download Xenakis1 project data set animal data, as uploaded
• Download Xenakis1 animal data matrix with factor-related expansion applied as necessary
• Download Xenakis1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Xenakis1 measures:

MA:0002501 plasma
MP:0001259 abnormal body weight
MP:0001392 abnormal locomotor behavior
MP:0001408 stereotypic behavior
MP:0001516 abnormal motor coordination/balance
MP:0003492 abnormal involuntary movement
MP:0012693 abnormal haloperidol metabolism
VT:0001259 body mass
VT:0001392 locomotor behavior trait
VT:0001516 motor coordination/balance trait
VT:0002121 metabolism trait
VT:0003492 involuntary movement trait
VT:0010471 exploratory behavior trait
VT:0010487 response to xenobiotic stimulus trait

Investigators	James G Xenakis University of North Carolina, Chapel Hill, NC Paola Giusti-Rodriguez University of North Carolina, Chapel Hill, NC Patrick F Sullivan University of North Carolina, Chapel Hill, NC Fernando Pardo-Manuel de Villena University of North Carolina, Chapel Hill, NC Fei Zou University of North Carolina, Chapel Hill, NC
Participants	Crowley JJ, Nonneman RJ, DeCristo DM, Ryan A, Quackenbush CR, Miller DR, Shaw GD, Zhabotynsky V
Contact	Fei Zou fzou@bios.unc.edu
Funding Provided By	NIH MH090338, HG006582; University Cancer Research Funds granted to the Lineberger Comprehensive Cancer Center (MCR012CCRI)
Project type	Phenotype strain survey data set
MPD identifiers	Xenakis1 MPD:1006
Data changelog	No updates/corrections. Initial release date: 09/2019.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Xenakis1:7	Xenakis1	body weight	(none)	body weight, placebo group [g] bw_cont 111150 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:9	Xenakis1	body weight	haloperidol	body weight, treatment group [g] bw_Rx 111152 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:11	Xenakis1	inclined screen test	(none)	latency to move all four paws (extrapyramidal symptoms), placebo group [s] latency_cont 111154 pre-treatment post-treatment	CC RIX	73	both	7-9wks	N=3

Xenakis1:13	Xenakis1	inclined screen test	haloperidol	latency to move all four paws (extrapyramidal symptoms), treatment group [s] latency_Rx 111156 pre-treatment post-treatment	CC RIX	73	both	7-9wks	N=3

Xenakis1:15	Xenakis1	open field test	(none)	distance traveled, 30 min test, placebo group [cm] distance_cont 111158 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:17	Xenakis1	open field test	haloperidol	distance traveled, 30 min test, treatment group [cm] distance_Rx 111160 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:19	Xenakis1	open field test	(none)	vertical activity (beam breaks), 30 min test, placebo group [n] vertical_cont 111162 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:21	Xenakis1	open field test	haloperidol	vertical activity (beam breaks), 30 min test, treatment group [n] vertical_Rx 111164 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:23	Xenakis1	open field test	(none)	time spent in center of arena, 30 min test, placebo group [s] center_cont 111166 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:25	Xenakis1	open field test	haloperidol	time spent in center of arena, 30 min test, treatment group [s] center_Rx 111168 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:27	Xenakis1	open field test	(none)	stereotypy activity (beam breaks), 30 min test, placebo group [n] stereotypy_cont 111170 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:29	Xenakis1	open field test	haloperidol	stereotypy activity (beam breaks), 30 min test, treatment group [n] stereotypy_Rx 111172 pre-treatment post-treatment	CC RIX	73	both	7-13wks	N=3

Xenakis1:31	Xenakis1	behavior observation	haloperidol	subtle vacuous chewing movements, 15 min test, treatment group, post-treatment [n] subtle_vcm_Rx_post 111174	CC RIX	73	both	11-13wks	N=5

Xenakis1:32	Xenakis1	behavior observation	haloperidol	overt vacuous chewing movements, 15 min test, treatment group, post-treatment [n] overt_vcm_Rx_post 111175	CC RIX	73	both	11-13wks	N=5

Xenakis1:33	Xenakis1	behavior observation	haloperidol	tongue protrusions, 15 min test, treatment group, post-treatment [n] tongue_Rx_post 111176	CC RIX	73	both	11-13wks	N=5

Xenakis1:34	Xenakis1	behavior observation	haloperidol	jaw tremors, 15 min test, treatment group, post-treatment [n] jawtremor_Rx_post 111177	CC RIX	73	both	11-13wks	N=5

Xenakis1:36	Xenakis1	drug and metabolite quantification	haloperidol	plasma haloperidol concentration, treatment group, post-treatment [ng/dL] haloperidol_conc_post 111179	CC RIX	53	both	11-13wks	N=2

Xenakis1: Drug study: Haloperidol antipsychotic effects on behavioral phenotypes in 73 F1 hybrids of Collaborative Cross strains of mice (RIX) (2020)

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