GMC04: Motor coordination and balance assessed by the rotarod test in 7 inbred founder strains of the Collaborative Cross (2020)

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.   PubMed 32060626     FullText


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GMC04 downloads
• Download GMC04 project data set     animal data, as uploaded
• Download GMC04 animal data matrix     with factor-related expansion applied as necessary
• Download GMC04 strain means, SD, N, etc.     one row per strain/sex/measure
Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Becker L, Klopstock T, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC04     MPD:553
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
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The rotarod test is used to assess motor coordination and balance in rodents. It is measured as latency to fall from a spinning rotarod which, in this study, is accelerating from 4 to 40 rpm in 5 min (without a training session prior to the testing).

Experimental groups in this study:
• None     • None     • None     • None     • None    

Procedures conducted:
• rotarod  Latency to fall from accelerating rotarod.

Mice: inbred w/CC7   8 strains   ♀♂   age 9-10wks   5 experimental groups