MPD: Data set: CSNA02

This study uses the 8 Collaborative Cross founder strains and 2 of the CC strains (10 for selected measures) to examine reward sensitivity and impulsivity traits. Mice were tested for activity in an open field and reward sensitivity (intake of chocolate BOOST). Mice were then divided into two counterbalanced groups and underwent reversal learning (impulsive action) or delay discounting (impulsive choice). This research was conducted within the inter-laboratory effort of the Center for Systems Neurogenetics of Addiction (CSNA) to characterize CC and DO mice for multiple, drug abuse related traits.

Procedures conducted:

• open field test		Locomotor response to novelty, habituation.
• bottle choice test		Palatable food consumption, preference for Boost solution.
• operant conditioning chamber		Reversal learning (impulsive action) and delay discounting (impulsive choice).

CSNA02 downloads
• Download CSNA02 project data set animal data, as uploaded
• Download CSNA02 animal data matrix with factor-related expansion applied as necessary
• Download CSNA02 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to CSNA02 measures:

MP:0001392 abnormal locomotor behavior
MP:0001422 abnormal drinking behavior
MP:0001425 abnormal alcohol consumption
MP:0002063 abnormal learning/memory/conditioning
MP:0002803 abnormal operant conditioning behavior
MP:0010698 abnormal impulsive behavior control
VT:0001392 locomotor behavior trait
VT:0001422 drinking behavior trait
VT:0002063 learning/memory/conditioning trait
VT:0010473 impulsivity behavior trait
VT:0010489 response to alcohol trait
VT:0010531 operant conditioning behavior trait

Investigators	J D Jentsch Binghamton University, Binghamton, NY Lauren S Bailey Binghamton University, Binghamton, NY Jared Bagley Binghamton University, Binghamton, NY
Contact	J D Jentsch jjentsch@binghamton.edu Lab web site
Affiliated Center	Center for Systems Neurogenetics of Addiction (CSNA)
Acknowledgements	Funding provided by NIH DA041602
Project type	Phenotype strain survey data set
MPD identifiers	CSNA02 MPD:622
Data changelog	No updates/corrections. Initial release date: 12/2023.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
CSNA02:1	CSNA02	open field test	(none)	distance traveled, 40 min test [cm] locomotor 62201 day 1 day 2 day 2 minus day 1	inbred	10	both	10wks	N=8

CSNA02:4	CSNA02	bottle choice test	(none)	average number of Boost licks over last 3 days of consumption adjusted for body weight [n] boost_licks 62204	inbred	10	both	10-11wks	N=8

CSNA02:5	CSNA02	bottle choice test	(none)	ratio of Boost licks to total licks over last 3 days of consumption adjusted for body weight [%] boost_pref 62205	inbred	10	both	10-11wks	N=8

CSNA02:6	CSNA02	operant conditioning chamber	(none)	total number of trials in reversal learning needed to meet criteria [n] trials 62206 acquisition reversal	inbred	10	both	12-14wks	N=5

CSNA02:8	CSNA02	operant conditioning chamber	(none)	number of anticipatory nose pokes made in correct flanking hole during reversal learning [n] pokes_corr 62208 acquisition reversal	inbred	10	both	12-14wks	N=5

CSNA02:10	CSNA02	operant conditioning chamber	(none)	number of anticipatory nose pokes made in incorrect flanking hole during reversal learning [n] pokes_incorr 62210 acquisition reversal	inbred	10	both	12-14wks	N=5

CSNA02:12	CSNA02	operant conditioning chamber	(none)	omissions during reversal learning divided by total number of trials [n] omits 62212 acquisition reversal	inbred	10	both	12-14wks	N=5

CSNA02:14	CSNA02	operant conditioning chamber	(none)	latency to initiate trials divided by total number of trials [s] trial_latency 62214 acquisition reversal	inbred	10	both	12-14wks	N=5

CSNA02:16	CSNA02	operant conditioning chamber	(none)	latency to receive Boost divided by total number of trials [s] reward_latency 62216 acquisition reversal	inbred	10	both	12-14wks	N=5

CSNA02:18	CSNA02	operant conditioning chamber	(none)	scaling factor (k-value) for delay discounting (impulsive choice) scaling_factor 62218	inbred	10	both	12-14wks	N=5

CSNA02:19	CSNA02	operant conditioning chamber	(none)	side bias (b-value) for delay discounting (impulsive choice) side_bias 62219	inbred	10	both	12-14wks	N=5

CSNA02:20	CSNA02	body weight	(none)	body weight for ethanol study [g] bw 62220 day 1 day 2 day 3	inbred	18	both	16-39wks	N=6

CSNA02:23	CSNA02	bottle choice test	ethanol	ethanol consumption adjusted per kg body weight 'drinking in the dark' [g/kg] EtOH_adj 62223 day 1 day 2 day 3	inbred	18	both	16-39wks	N=6

CSNA02:26	CSNA02	bottle choice test	ethanol	licks on ethanol bottle as a percentage of total licks 'drinking in the dark' [%] EtOH_licks 62226 day 1 day 2 day 3	inbred	18	both	16-39wks	N=5

CSNA02: Reward sensitivity, impulse action and choice, and drinking in the dark in Collaborative Cross strains of mice and 8 founder inbred strains (2023)