MPD: Data set: GMC06

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14. PubMed 32060626 FullText

GMC06 downloads
• Download GMC06 project data set animal data, as uploaded
• Download GMC06 animal data matrix with factor-related expansion applied as necessary
• Download GMC06 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to GMC06 measures:

MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001553 abnormal circulating free fatty acids level
MP:0011969 abnormal circulating triglyceride level
MP:0011973 abnormal circulating glycerol level
MP:0020151 abnormal circulating non-HDL cholesterol level
VT:0000180 blood cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000188 blood glucose amount
VT:0001259 body mass
VT:0001553 blood free fatty acid amount
VT:0002644 blood triglyceride amount
VT:0003442 blood glycerol amount
VT:0010474 blood non-HDL cholesterol amount

Institutional authorship	German Mouse Clinic and Department of Infection Genetics, HZI Lab web site
Investigators	GMC Management Team German Mouse Clinic, Neuherberg GERMANY
Participants	Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Rathkolb B, Wolf E, Lengger C, Kollmus H, Schughart K
Contact	GMC Management Team coregmc@helmholtz-muenchen.de Lab web site
Affiliated Center	German Mouse Clinic (GMC)
Acknowledgements	Funding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type	Phenotype strain survey data set
MPD identifiers	GMC06 MPD:555
Data changelog	No updates/corrections. Initial release date: 02/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Experimental groups in this study:
• None • None • None • None • None

Procedures conducted:

• metabolic panel		Glucose, glycerol. 16h fast.
• lipid profile		Cholesterol, HDL, non-HDL, triglycerides, fatty acids. 16h fast, plasma.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
GMC06:1	GMC06	body weight	(none)	body weight [g] bw 55501 before fast after 16h fast	inbred w/CC8	8	both	10-11wks	N=14

GMC06:11	GMC06	metabolic panel	(none)	glucose (plasma GLU, 16h fast) [mmol/L] GLU 55511	inbred	5	both	10-11wks	N=16

GMC06:12	GMC06	metabolic panel	(none)	glycerol (plasma, 16h fast) [mmol/L] Glycerol 55512	inbred	5	both	10-11wks	N=16

GMC06:21	GMC06	lipid profile	(none)	total cholesterol (plasma CHOL, 16h fast) [mmol/L] CHOL 55521	inbred	5	both	10-11wks	N=16

GMC06:22	GMC06	lipid profile	(none)	HDL cholesterol (plasma HDL, 16h fast) [mmol/L] HDL 55522	inbred	5	both	10-11wks	N=16

GMC06:23	GMC06	lipid profile	(none)	non-HDL cholesterol (plasma non-HDL) (CHOL minus HDL, 16h fast) [mmol/L] nonHDL 55523	inbred	5	both	10-11wks	N=16

GMC06:24	GMC06	lipid profile	(none)	non-esterified fatty acids (plasma NEFA, 16h fast) [mmol/L] NEFA 55524	inbred	5	both	10-11wks	N=16

GMC06:25	GMC06	lipid profile	(none)	triglyceride (plasma TG, 16h fast) [mmol/L] TG 55525	inbred	5	both	10-11wks	N=16

GMC06: Glucose levels and lipid profiles after fasting in 5 inbred founder strains of the Collaborative Cross (2020)