MPD: Data set: McMullan7

McMullan RC, Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE, de Villena FP. CC002/Unc females are mouse models of exercise-induced paradoxical fat response. Physiol Rep. 2018 Jun;6(12):e13716. doi: 10.14814/phy2.13716. PubMed 29924460

Four strains were selected based on the following criteria: 1) ability to run on treadmills, 2) fat response type to voluntary exercise, 3) endurance ability (MPD datasets: McMullan1, McMullan2, McMullan3; McMullan4; all data was collected in older females). Selected strains were: CC002/Unc adverse fat responder, low endurance; CC027/GeniUnc adverse fat responder, high endurance; CC013/GeniUnc standard fat responder, low endurance; and CC037/TauUnc standard fat responder, high endurance. Energy balance parameters were assessed before and after 4 wks of forced exercise on a treadmill.

Experimental groups in this study:
• None • None • None

Procedures conducted:

• monitoring system		Locomotor activity, respiratory activity, body heat production, during 4 weeks of treadmill-based exercise training. 3 intensity cohorts.
• intake monitoring		Food and water intake, during 4 weeks of treadmill-based exercise training. 3 intensity cohorts.

McMullan7 downloads
• Download McMullan7 project data set animal data, as uploaded
• Download McMullan7 animal data matrix with factor-related expansion applied as necessary
• Download McMullan7 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to McMullan7 measures:

MA:0000327 respiratory system
MP:0001392 abnormal locomotor behavior
MP:0002336 abnormal pulmonary gas exchange
MP:0005288 abnormal oxygen consumption
MP:0005449 abnormal food intake
MP:0008961 abnormal basal metabolism
MP:0008962 abnormal carbon dioxide production
MP:0011947 abnormal fluid intake
VT:0001392 locomotor behavior trait
VT:0001422 drinking behavior trait
VT:0001431 eating behavior trait
VT:0002121 metabolism trait
VT:0002336 pulmonary gas exchange trait
VT:0002338 pulmonary ventilation trait

Investigators	Rachel C McMullan University of North Carolina, Chapel Hill, NC Fernando Pardo-Manuel de Villena University of North Carolina, Chapel Hill, NC
Participants	Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE
Contact	Fernando Pardo-Manuel de Villena fernando@med.unc.edu Lab web site
Part of a series:	• McMullan6 see McMullan6 • McMullan7 (this project) McMullan7
Acknowledgements	Funding provided by NIH DK056350, AI100625, AI109761, AG049092, MH100241, DK05350, Al100625
Project type	Phenotype strain survey data set
MPD identifiers	McMullan7 MPD:616
Data changelog	No updates/corrections. Initial release date: 07/2018.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
McMullan7:1	McMullan7	monitoring system	(none)	mean oxygen consumption at start of experiment, during day [mL/h] VO2_d_start 61601 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:4	McMullan7	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during day [mL/h] VO2_d_end 61604 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:7	McMullan7	monitoring system	(none)	mean oxygen consumption at start of experiment, during night [mL/h] VO2_n_start 61607 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:11	McMullan7	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during night [mL/h] VO2_n_end 61611 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:14	McMullan7	monitoring system	(none)	mean carbon dioxide production at start of experiment, during day [mL/h] VCO2_d_start 61614 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:17	McMullan7	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during day [mL/h] VCO2_d_end 61617 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:21	McMullan7	monitoring system	(none)	mean carbon dioxide production at start of experiment, during night [mL/h] VCO2_n_start 61621 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:24	McMullan7	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during night [mL/h] VCO2_n_end 61624 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:27	McMullan7	monitoring system	(none)	mean respiratory exchange rate at start of experiment, during day [ratio] RER_d_start 61627 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:31	McMullan7	monitoring system	exercise	mean respiratory exchange rate after 4 wks of treatment, during day [ratio] RER_d_end 61631 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:34	McMullan7	monitoring system	(none)	mean respiratory exchange rate at start of experiment, during night [ratio] RER_n_start 61634 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:37	McMullan7	monitoring system	exercise	mean respiratory exchange rate after 4 wks of treatment, during night [ratio] RER_n_end 61637 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:41	McMullan7	monitoring system	(none)	activity (beam breaks) at start of experiment, during day [n] act_d_start 61641 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:44	McMullan7	monitoring system	exercise	activity (beam breaks) after 4 wks of treatment, during day [n] act_d_end 61644 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:47	McMullan7	monitoring system	(none)	activity (beam breaks) at start of experiment, during night [n] act_n_start 61647 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:51	McMullan7	monitoring system	exercise	activity (beam breaks) after 4 wks of treatment, during night [n] act_n_end 61651 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:54	McMullan7	monitoring system	(none)	mean heat production at start of experiment, during day [kcal/h/kg] heat_d_start 61654 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:57	McMullan7	monitoring system	exercise	mean heat production after 4 wks of treatment, during day [kcal/h/kg] heat_d_end 61657 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:61	McMullan7	monitoring system	(none)	mean heat production at start of experiment, during night [kcal/h/kg] heat_n_start 61661 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:64	McMullan7	monitoring system	exercise	mean heat production after 4 wks of treatment, during night [kcal/h/kg] heat_n_end 61664 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:67	McMullan7	intake monitoring	(none)	total food intake at start of experiment, during day [g] food_d_start 61667 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:71	McMullan7	intake monitoring	exercise	total food intake after 4 wks of treatment, during day [g] food_d_end 61671 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:74	McMullan7	intake monitoring	(none)	total food intake at start of experiment, during night [g] food_n_start 61674 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:77	McMullan7	intake monitoring	exercise	total food intake after 4 wks of treatment, during night [g] food_n_end 61677 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:81	McMullan7	intake monitoring	(none)	total water intake at start of experiment, during day [mL] water_d_start 61681 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:84	McMullan7	intake monitoring	exercise	total water intake after 4 wks of treatment, during day [mL] water_d_end 61684 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:87	McMullan7	intake monitoring	(none)	total water intake at start of experiment, during night [mL] water_n_start 61687 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7:91	McMullan7	intake monitoring	exercise	total water intake after 4 wks of treatment, during night [mL] water_n_end 61691 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8

McMullan7: Energy balance traits after forced exercise in 4 Collaborative Cross strains of mice (2018)