McMullan4: Body weight and composition after voluntary exercise in females of 13 Collaborative Cross strains of mice (2018)

McMullan RC, Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE, de Villena FP. CC002/Unc females are mouse models of exercise-induced paradoxical fat response. Physiol Rep. 2018 Jun;6(12):e13716. doi: 10.14814/phy2.13716.   PubMed 29924460  


         
Female mice (n=173 total mice; ~9 months +/- 4 weeks) from 13 CC strains were assessed before and after two weeks of voluntary exercise (running wheel accessibility) for body weight and composition as well as activity levels and food intake.

Procedures conducted:
• body weight  Body weight before and after 2 weeks of exercise wheel availability.
• MRI  Body composition (fat and lean mass) before and after 2 weeks of exercise wheel availability.
• running wheel monitoring  Running wheel activity on days 11 and 12.
• intake monitoring  Food intake during 2 weeks of exercise wheel availability.

McMullan4 downloads
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Investigators Rachel C McMullan       University of North Carolina,  Chapel Hill, NC
Fernando Pardo-Manuel de Villena       University of North Carolina,  Chapel Hill, NC
Participants Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE
ContactFernando Pardo-Manuel de Villena     fernando@med.unc.edu     Lab web site
AcknowledgementsFunding provided by NIH DK056350, AI100625, AI109761, AG049092, MH100241, DK05350, Al100625
Project type Phenotype strain survey data set
MPD identifiersMcMullan4     MPD:613
Data changelog No updates/corrections.       Initial release date: 07/2018.
Formatted citation
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Mice: CC   13 strains   ♀   age 32-40wks   2 experimental groups

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    McMullan4 body weight (none) body weight at start of experiment   [g]  bw_start   61301     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 body weight exercise body weight after 2 wks of treatment   [g]  bw_end   61306     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 body weight exercise body weight, response after 2 wks of treatment   [%]  bw_resp   61311     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 MRI (none) percentage of body mass that is fat at start of experiment   [%]  fat_start   61316     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 MRI exercise percentage of body mass that is fat after 2 wks of treatment   [%]  fat_end   61321     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 MRI exercise percentage of body mass that is fat, response after 2 wks of treatment   [%]  fat_resp   61326     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 MRI (none) percentage of body mass that is lean at start of experiment   [%]  lean_start   61331     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 MRI exercise percentage of body mass that is lean after 2 wks of treatment   [%]  lean_end   61336     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 MRI exercise percentage of body mass that is lean, response after 2 wks of treatment   [%]  lean_resp   61341     control group    wheel access CC 13 f 32-40wks N=6
    McMullan4 running wheel monitoring exercise mean total daily distance for days 11-12 of wheel access   [km]  distance   61346 CC 13 f 32-40wks N=7
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